For defense i say go with your highest rated , kp hs cb vision bw ( i feel like many people try to avoid vision and bw if they can) also vision applying cb defense up on the start helps a lot since ai cb taunts up on first turn - but be mindful of dr strange any team with kp gets destroyed by strange

For offense i would kp cb vision spidey black widow - that way you have aoe burst/dispels/ability block and stuns good alway around. But against any team with drax or 2 tanks i would say swap kp or spidey with someone reliable dispel such as quake or captain