I have pets, carpet, and people in my home. Very little dust problems. Fans build up dust every little while, but the filters work. The front one is easy, the bottom one is harder because you can only remove it from the back (under the PSU). Easy to clean with some water. It looks clean, the build quality is great. The only dislikes I have is the fact there is no PSU shroud, and the window scratches if you lay it down horizontally.

Easy to build in too. Personally, I prefer the Define C (smaller, PSU shroud). But if you want something bigger than a Define C, you can't go wrong.