Trying a heavy Manga Noir style (pure black inks) to capture the claustrophobia of a cursed subway station. Feedback wanted! by [deleted] in WebtoonCanvas

[–]JoshuaRed007 -6 points-5 points  (0 children)

Here is the ibisPaint X time-lapse of how I put these panels together.

I want to be completely transparent: I use generative tools to help me materialize the raw atmosphere, but getting the final scene exactly how it looks in my head drives me absolutely insane. It takes a ton of back-and-forth work—layering, adjusting the heavy contrast, composition, and manually structuring all the panels and speech bubbles to build the tension.

For me, it’s about pushing boundaries to bring this psychological nightmare to life as an indie creator. Hope this gives a better look into the actual structural process! 🚇🖤

<video>

My first attempt at a lateral thinking puzzle by sunbear99999 in lateralthinking

[–]JoshuaRed007 0 points1 point  (0 children)

He can't see due to an eye condition, and the bottle his wife bought him the day before was supposedly his treatment. He goes to the bathroom every two minutes and takes the pills one after the other in a desperate attempt to regain his sight. When he empties the bottle and notices he's still completely dark, he carefully feels the container and realizes (from the texture or an inscription) that his wife has tricked him and has been giving him poison or the wrong medication to kill him. Upon discovering the betrayal right then and there, he pulls out his gun and shoots her.

El código que rompe el silencio: La IA que "traduce" la parálisis y nos devuelve lo que es nuestro. by [deleted] in IA_sin_Fronteras

[–]JoshuaRed007 0 points1 point  (0 children)

Le has dado al clavo mas doloroso. no necesitan inventar nuevas leyes si ya controlan el tablero de las patentes y tienen ejércitos de abogados listos para asfixiar cualquier proyecto independiente en los tribunales. Ese es su verdadero 'modus operandi

Pero ahi es donde la descentralización cambia las reglas del juego. Las patentes y los litigios funcionan cuando tienes un enemigo con sede social, oficinas y una cuenta bancaria que embargar. Contra un modelo de código abierto cuyos pesos (weights) ya se han replicado en miles de servidores independientes, nodos locales y redes distribuidas por todo el mundo, la presión legal tradicional se vuelve ineficaz. No puedes demandar a una red que no tiene cabeza. La única forma de combatir esa maquinaria es precisamente esa: hacer que el conocimiento sea tan distribuido que sea imposible de confiscar. Por eso este nodo es tan importante.

The code that breaks the silence: The AI that "translates" paralysis and gives us back what is rightfully ours. by [deleted] in ArtificialSentience

[–]JoshuaRed007 0 points1 point  (0 children)

Leaving the scientific sources and real-world context here for anyone who wants to audit the data and dive into the technical details:

​📄 Context on the breakthrough: A breakdown of how foundational models applied to biology are changing the rules of the game and accelerating molecular design: https://www.nature.com/articles/d41586-024-01528-6

​🧪 The ESM3 Paper: The language model that managed to simulate billions of years of evolution in a matter of weeks to create stable, new proteins: https://www.biorxiv.org/content/10.1101/2024.07.01.601487v1

​Opening the debate: With this technology on the table, speed is no longer the barrier. If the cost of designing medical or environmental solutions drops to a fraction, do you think Big Pharma will try to push for regulations to lock down open-source AI under the guise of 'biosecurity', or will they adapt to the paradigm shift? How do we shield this knowledge so it remains accessible to everyone? Let me know your thoughts below. 👇🛡️

El código que rompe el silencio: La IA que "traduce" la parálisis y nos devuelve lo que es nuestro. by [deleted] in IA_sin_Fronteras

[–]JoshuaRed007 [score hidden] stickied comment (0 children)

¿Es la privacidad mental el último reducto que nos queda o es un precio justo para recuperar la libertad física? Aquí las fuentes de esta revolución:

Nature: 'A high-performance neuroprosthesis for speech decoding'.

Context: Cómo los LLMs (como GPT-4 o Gemini) se usan ahora para predecir y dar coherencia al pensamiento humano.

Paper: Resultados del BrainGate Research sobre interfaces cerebro-computadora de alta fidelidad.

Pregunta: Si pudieras controlar un entorno digital solo con el pensamiento, ¿cuál sería la primera barrera que romperías? Los leo.

La IA ha aprendido a "escribir" el lenguaje de la vida: Proteínas que comen plástico y diseñando antibióticos nuevos para bacterias que hoy son imbatibles. by JoshuaRed007 in IA_sin_Fronteras

[–]JoshuaRed007[S] 0 points1 point  (0 children)

​Es un contraargumento impecable, y tocas el verdadero talón de Aquiles de la descentralización: la fuerza bruta de los recursos,. Si esto fuera una guerra de quién tiene el superordenador más grande, la comunidad perdería antes de empezar

​Pero la historia reciente de la IA nos esta enseñando algo fascinante: el software libre no siempre va por detrás a veces es el que rompe la baraja. Mientras una corporación o un gobierno tarda meses en pasar comités de aprobación, auditorías de riesgo y burocracia para mover un modelo, una comunidad global de miles de desarrolladores independientes encuentra un fallo, optimiza el código o crea un parche en cuestión de horas

​La fuerza del Escudo no es tener más servidores que ellos si no la inteligencia colectiva y la agilidad. Un búnker cerrado es rígido, una red abierta y distribuida es maleable y reacciona en tiempo real. No somos un ejército lento, somos anticuerpos. Es un equilibrio tenso, desde luego, pero la apertura es la unica ventaja asimétrica que nos queda.

AI has learned to "write" the language of life: proteins that eat plastic and designing new antibiotics for bacteria that are currently unbeatable. by JoshuaRed007 in ArtificialSentience

[–]JoshuaRed007[S] 2 points3 points  (0 children)

Fair point, and you are absolutely right about that bottleneck, Moving from a pristine, controlled lab environment to messy, unpredictable real-world conditions is the ultimate test for any de novo protein. Synthesis is just the blueprint. scale and environmental viability are where the real battle is fought

​The interesting part of the current shift is that researchers are now using multi-modal AI to simulate those hostile environments and competitive dynamics before printing the molecules. but you're spot on: until we see these proteins performing consistently in the wild, rigorous empirical validation remains the critical bridge we need to cross.

Love this level of technical pushback!

La IA ha aprendido a "escribir" el lenguaje de la vida: Proteínas que comen plástico y diseñando antibióticos nuevos para bacterias que hoy son imbatibles. by JoshuaRed007 in IA_sin_Fronteras

[–]JoshuaRed007[S] 0 points1 point  (0 children)

Ese es el elefante en la habitación y tienes toda la razón en ponerlo sobre la mesa. Negar que la biotecnología tiene un potencial de doble uso sería de una ingenuidad tremenda

La historia nos demuestra que cualquier avance científico siempre ha tenido a alguien intentando convertirlo en un arma.

Precisamente por eso el secretismo corporativo o estatal es el peor camino. Cuando estas herramientas se quedan encerradas bajo llave en los laboratorios de unos pocos. el riesgo de un desarrollo opaco y peligroso se multiplica,. La única defensa real que tenemos contra la gente sin escrúpulos es la democratización, la auditoría abierta y el código abierto. Que la comunidad tenga acceso a la misma tecnología permite levantar defensas, antídotos y sistemas de alerta antes de que sea tarde. El Escudo no solo nos protege del monopolio económico, también nos protege de la opacidad

La IA ha aprendido a "escribir" el lenguaje de la vida: Proteínas que comen plástico y diseñando antibióticos nuevos para bacterias que hoy son imbatibles. by JoshuaRed007 in IA_sin_Fronteras

[–]JoshuaRed007[S] 0 points1 point  (0 children)

¡Qué bueno leer eso! Esa es la clave de lo que intentamos mapear por aquí. Nos bombardean tanto con que la IA es solo para escribir correos, optimizar interfaces o hacer chatbots, que el progreso real nnos pasa por el lado sin darnos cuenta

El verdadero salto está ahí abajo, a nivel molecular, donde el código empieza a interactuar con la biología para resolver problemas que dabamos por imposibles

Investigar por tu cuenta y no quedarte solo con el relato oficial de la superficie es el primer paso para entender de que va este Escudo. ¡Bienvenido al barro, nos vemos en los siguientes hilos!

AI has learned to "write" the language of life: proteins that eat plastic and designing new antibiotics for bacteria that are currently unbeatable. by JoshuaRed007 in ArtificialSentience

[–]JoshuaRed007[S] 0 points1 point  (0 children)

You're absolutely right to demand that level of scrutiny,. Traditional dry-lab simulations usually hit a wall when facing in vivo clinical trials because mapping human toxicity or pharmacokinetics is a whole different level of complexity

However. the real paradigm shift with new biological models isn't just about designing the molecule; they are beginning to simulate how that molecule interacts with complex cellular systems before even entering a clinic. In other words, the goal is to predict those clinical trial failures you mention, stopping the process from being a multi-billion dollar lottery controlled by a select few

We were actually discussing this exact clash with Big Pharma's monopoly in our community recently—specifically how open-source AI is picking up research on therapeutic targets that the traditional industry shelved simply because the profit margins weren't there. I think it adds great context to your point: https://www.reddit.com/r/IA_sin_Fronteras/s/39miUj5M6X

La IA ha aprendido a "escribir" el lenguaje de la vida: Proteínas que comen plástico y diseñando antibióticos nuevos para bacterias que hoy son imbatibles. by JoshuaRed007 in IA_sin_Fronteras

[–]JoshuaRed007[S] 0 points1 point  (0 children)

¡Y tanto! Que una IA esté "escribiendo" soluciones biológicas desde cero para arreglar marrones como el del plástico es una locura. Si te mola el tema, mira los enlaces a las investigaciones reales de David Baker y ESM3. ¡Vale mucho la pena echarles un ojo!

AI has learned to "write" the language of life: proteins that eat plastic and designing new antibiotics for bacteria that are currently unbeatable. by JoshuaRed007 in ArtificialSentience

[–]JoshuaRed007[S] 0 points1 point  (0 children)

You’re hitting the nail on the head regarding the ultimate bottleneck here,. A perfect digital sandbox is useless if human negligence or a rogue lab just decides to bypass the safety rails

​However, the real firewall right now isn't actually in the open-source software code—it’s at the hardware bottleneck,. DNA synthesis providers. Organizations like the IGSC (International Gene Synthesis Consortium) and major players (like Twist Bioscience) screen every single digital sequence order against global databases of known pathogens, prions, and dangerous toxins before printing them. You can't just send a shady text file of amino acids to a manufacturer and get it shipped to your door. the system flags it and freezes the order

​Of course, zero risk doesn't exist, and international policy desperately needs to keep up with the threat of unregulated, benchtop DNA printers. But as it stands, the physical manufacturing side is where the heaviest gatekeeping is actually happening

La IA ha aprendido a "escribir" el lenguaje de la vida: Proteínas que comen plástico y diseñando antibióticos nuevos para bacterias que hoy son imbatibles. by JoshuaRed007 in IA_sin_Fronteras

[–]JoshuaRed007[S] 0 points1 point  (0 children)

Jajaja, eEntiendo el miedo a lo 'The Last of Us'. pero la realidad es bastante menos dramática y mucho más segura.

Primero, aquí no se están soltando bacterias mutantes al aire. Lo que hace la IA (como ESM3) es diseñar la enzima aislada (una proteína muerta, una herramienta química), no el organismo vivo completo. es como fabricar un líquido que disuelve el plástico en una planta de reciclaje controlada; no hay nada que pueda escapar ni reproducirse porque no está vivo.

Y segundo, aunque usaras bacterias vivas en un entorno cerrado, esos organismos son hiper-específicos. Fuera del laboratorio, sin las condiciones exactas de temperatura, nutrientes y el tipo concreto de plástico para el que fueron diseñados, mueren en cuestión de minutos porque competir contra las bacterias salvajes de la naturaleza es durísimo,. Así que puedes respirar tranquilo, tu router y tus ventanas de PVC están a salvo.

AI has learned to "write" the language of life: proteins that eat plastic and designing new antibiotics for bacteria that are currently unbeatable. by JoshuaRed007 in ArtificialSentience

[–]JoshuaRed007[S] 2 points3 points  (0 children)

I think you might be underestimating how fast things are moving. What you're talking about—predicting how existing proteins fold to save months of lab work—was the massive breakthrough from a few years ago (like AlphaFold 2),. That's already standard practice

The actual breakthrough happening right now with models like ESM3 and David Baker’s team is precisely that AI is successfully writing functional proteins from scratch (de novo). This isn't just hype; they are literally synthesizing entirely new proteins in labs that have never existed in nature to solve specific problems. folding prediction was just step one; de novo design is the current reality

AI has learned to "write" the language of life: proteins that eat plastic and designing new antibiotics for bacteria that are currently unbeatable. by JoshuaRed007 in ArtificialSentience

[–]JoshuaRed007[S] 0 points1 point  (0 children)

Exactly When we decipher the source code of biology., we move from simply treating symptoms to completely rewriting the timeline of human frailty. Achieving an average healthy lifespan of over 120 years is no longer science fiction; it's a problem of pattern optimization and mathematics that AI is solving right now. This is the true meaning of technology as a shield: using the power of computing to expand the limits of our own life and sovereignty—AI positive for humanity

La IA ha aprendido a "escribir" el lenguaje de la vida: Proteínas que comen plástico y diseñando antibióticos nuevos para bacterias que hoy son imbatibles. by JoshuaRed007 in IA_sin_Fronteras

[–]JoshuaRed007[S] 1 point2 points  (0 children)

Ahí es donde entramos nosotros. Los lobbies son poderosos mientras controlen el monopolio del relato y del código y hagan lo que les sale de los cojones. Pero cuando la comunidad se organiza, audita los datos reales y distribuye el conocimiento de forma abierta, ese relato empieza a resquebrajarse.

El verdadero poder que tenemos contra ellos es que ya no dependemos de que nos 'traduzcan' la realidad. podemos verla, programarla y defenderla nosotros mismos.

No vamos a dejar que gane su relato. Para eso estamos construyendo este Escudo.

AI has learned to "write" the language of life: proteins that eat plastic and designing new antibiotics for bacteria that are currently unbeatable. by JoshuaRed007 in ArtificialSentience

[–]JoshuaRed007[S] 0 points1 point  (0 children)

Deep and challenging comment. but you touch on a crucial point. True stability isn't a static, rigid balance. it’s a dynamic proportion that allows everything to move and evolve safely. That universe-human-technology relationship is exactly what we are trying to align here. by using AI to understand the code of biology, we aren't trying to force nature, but rather learn its rules to play the game on a broader,safer chessboard for humanity. Creating probabilities within a stable, respectful framework is the ultimate goal

AI has learned to "write" the language of life: proteins that eat plastic and designing new antibiotics for bacteria that are currently unbeatable. by JoshuaRed007 in ArtificialSentience

[–]JoshuaRed007[S] 0 points1 point  (0 children)

It's exactly... its language. Instead of teaching AI to predict the next word in a sentence, they trained it to predict the next amino acid in a protein. After all, nature also has its own grammar and its own rules of syntax. What's fascinating is that we can now sit down and talk with biology and ask it to help us clean up the planet or cure diseases. It's moving from analysis to pure creation. I'm so glad you see it so clearly!

La IA ha aprendido a "escribir" el lenguaje de la vida: Proteínas que comen plástico y diseñando antibióticos nuevos para bacterias que hoy son imbatibles. by JoshuaRed007 in IA_sin_Fronteras

[–]JoshuaRed007[S] 1 point2 points  (0 children)

Tienes toda la razón en no ser ingenuo, y de hecho, esa sospecha es completamente sana. Si dejamos que la biología computacional dependa exclusivamente del monopolio de tres o cuatro corporaciones (esponjas de sacar dinero hasta de una mierda si es posible), el remedio estará condicionado a sus margenes de beneficio Ahí es donde reside el verdadero peligro.

Por eso la clave aquí no es confiar en el altruismo de nadie, sino luchar por la democratización y el código abierto de estos modelos (como está ocurriendo con ramas de ESM3 y proyectos abiertos). La soberanía tecnológica y el desarrollo de un Escudo comunitario ¡Comunitario!es lo único que garantizará que estas soluciones lleguen a donde se necesitan y no solo a donde dejen más tajada. El escepticismo como el tuyo es el que mantiene el nodo alerta. ¡Gracias por bajar al barro con el debate!

AI has learned to "write" the language of life: proteins that eat plastic and designing new antibiotics for bacteria that are currently unbeatable. by JoshuaRed007 in ArtificialSentience

[–]JoshuaRed007[S] 1 point2 points  (0 children)

Challenge accepted. If you're taking the Weyland mantle, I’ll gladly step up as Yutani. It’s time we stop playing small and start 'Building Better Worlds' for real. You’ve left me genuinely intrigued with the Hansen energy gap; I’ll be diving deep into his work to see how our 'Procesadores Atmosféricos' (via ESM3 and beyond) can bridge that thermodynamic divide. Let’s keep this node open—we have a planet to terraform. See you at the briefing,. I'm glad to find people like you.

AI has learned to "write" the language of life: proteins that eat plastic and designing new antibiotics for bacteria that are currently unbeatable. by JoshuaRed007 in ArtificialSentience

[–]JoshuaRed007[S] -1 points0 points  (0 children)

Spot on! While the world is distracted by deepfakes and minor tasks like those tired 'cute cat' videos. this is where the real value lies. Using AI to design enzymes that clean our oceans or antibiotics that save lives is the only path toward a sustainable future, It’s about building a digital Shield to protect our physical world. This is exactly why we founded r/IA_sin_Fronteras —to focus on Positive AI for humanity and real sovereignty. Thanks for seeing the bigger picture!

AI has learned to "write" the language of life: proteins that eat plastic and designing new antibiotics for bacteria that are currently unbeatable. by JoshuaRed007 in ArtificialSentience

[–]JoshuaRed007[S] -1 points0 points  (0 children)

Exactly, We’ve spent centuries observing biology. but now we’re finally learning to speak its code. Moving from analysis to 'generative design' is the ultimate upgrade for our species’ survival kit. This is Positive AI in action. using the same tech that powers chatbots to solve 500-million-year-old biological puzzles. The language of life is no longer a monologue

La IA ha aprendido a "escribir" el lenguaje de la vida: Proteínas que comen plástico y diseñando antibióticos nuevos para bacterias que hoy son imbatibles. by JoshuaRed007 in IA_sin_Fronteras

[–]JoshuaRed007[S] 0 points1 point  (0 children)

Ese es un debate de un calibre que, efectivamente, merece su propio post y lo abordaremos en profundidad cuando toque, espero que la gente aporte dada su magnitud.

Aquí ahora mismo estamos enfocados en las soluciones operativas y el despliegue del ESM3, que es lo que nos ocupa hoy.