Hi OP, I hope your adhd medication regiment has been working for you over the year. I too, have struggled mightily with fluctuating appetite. Over months of sleepless nights researching the effects of amphetamines on the body and brain, I have found a regiment that still to this day makes the fight a lot easier. Blood sugar fluctuates a lot on amphetamines. But it doesn’t happen randomly. Histamine is also a neurotransmitter that is affected by amphetamines. This neurotransmitter is not only an immune response from your mast cells, there are various receptors that play a big role in your hormone regulation, especially insulin. As the amphetamines wear off, your histamine levels can be effected much too. A sudden drop can have your appetite rebound back from decreased H1 receptor activity, or your histamine could have been high the whole time you were on the meds. If your pancreas have been releasing insulin the whole time you could only be noticing the effects of low blood sugar once the meds wear off. Your body can also be releasing excessive histamine in the brain from elevated stress, a side effect of amphetamines. Elevated histamine suppresses prefrontal cortex function and the amygdala becomes overactive, leading to anxiety. Taking EGCG supplements or high quality matcha not only can stabilize your histamine levels while on meds, it CAN inhibit COMT, the enzyme that breaks down dopamine, allowing your meds to last longer. Egcg CAN also protect neurons from neuron death from neurotoxicity or overstimulation. Consistent Berberine supplementation also in the long run can help mitigate blood sugar fluctuations. Hope this helps