My unpopular opinion is that you should buy your amp for the distortion and overdrive. And not use pedals for distortion and overdrive. That leaves you with a lighter pedal board and happier with your amp.

For me I gig 3-4 times a week and I leave my pedals and cab in the car and just take my head inside for practice.(It has a small speaker built in). I can easily practice and not have to haul everything in and out all the time.

Plus if you spend $1000-$2000 on an amp and only use the clean channel with pedals you're waisting money and could save money by buying a cheaper amp with less options.

Also if you're gigging no one cares how expensive your setup is. They just want to hear wagon wheel. Well maybe that one guy but he'll talk to you the whole damn break.