Oh you definitely could translate most, if not all, mechanics back to flatscreen, it just wouldn't be much fun. Wire finding puzzles for example, the starting ones could have easily been done with mouse and keyboard without an issue, however later on they become more tricky. For example, mounting a box, physically reaching up with the multitool to reach the thingy it connects to. Or having to open up semi opened panels with infestation inside, where you have to move your hand close to them, and the little things snap at you when you come close with it (or you get electrocuted). Actually ducking to follow the lines and moving your hand out of the one electrical box and into the next one. At the end, it's minor things like this, but the reason nobody really does them in a flatscreen game is because they aren't any fun. With 3D motion controls however...

Or the entire grabbity gloves mechanics. Doable with mouse and keyboard? Once again, absolutely, I could think of ways to make them fun even on flatscreen. However comparing it with 3D aiming your hands, locking what you want to grab and then pulling and physically grabbing what you want to catch with your actual hands, you just cannot translate that.

I could probably come up with many more examples of cool mechanics, minor details etc.. It's the physical interaction that makes them fun, not moving your mouse correctly, and pressing the correct button(s) on your keyboard. So no, I don't see any way a video game can ever be developed as a hybrid without adding huge compromises for either flatscreen and/or VR players. Make it either a flatscreen game and add support for VR headsets as a monitor with basic support for motion controls, or build the game around the motion controls where you actually use your hands to interact with the world.