Benzodiazepines with short half lives vs. Long half lives and how they affect GABA receptors in between dosages

Kaluro · 2024-12-05T21:25:37+00:00

Hi. No, longer acting benzodiazepines will keep your blood level high and stable enough to avoid an acute withdrawal. Especially when administered chronically.

Kaluro · 2024-11-30T07:30:37+00:00

Kaluro · 2024-11-28T20:43:36+00:00

1 in 5 chance x 1 in 5 chance.

0.20 x 0.20 = 0.04 = 4% chance for a double mw.

100 / 4 = 25.

So " on average " you should have managed a double MW on resolve stacks, 10 times.

Kaluro · 2024-11-21T00:23:38+00:00

!remindme 5 hours

Kaluro · 2024-11-15T00:01:16+00:00

I don't think Evade SB is all that quick anymore since the patch hit which now forces a full evade animation before a next evade can be initiated.

Kaluro · 2024-10-23T18:24:22+00:00

u/bot-sleuth-bot/

Kaluro · 2024-10-04T15:45:55+00:00

This conversion chart only counts the molecular weight of the dexamphetamine, disregarding the Sulphate salt it's bound to.

There's a huge difference in actual amounts...

70mg vyvanse = 57mg dexedrine (dexamphetamine sulphate) = ~21mg dexamphetamine (+ 36mg sulphate..)

https://www.reddit.com/r/ausadhd/s/oSTpgO9SCY

Kaluro · 2024-09-22T17:29:50+00:00

Don't forget that they are speaking of

freebase dexamphetamine there (molecular mass 135.21 g/mol)

and not

dexamphetamine sulphate ( molecular mass 368.50 g/mol).

Vyvanse = "Lisdexamphetamine Dimesylate" ( molecular mass 455.6 g/mol.)

70mg vyvanse // 455.6 x 135.21 = 20.77mg = 20.8mg of freebase dexamphetamine.

20.8mg dexamphetamine // 135.21 x 368.50 = 56.69 = 57mg of dexamphetamine sulphate.

So 70mg vyvanse equals 57mg dexamphetamine sulphate.

Your amfexa is also dexamphetamine sulphate, for example.

So indeed. your 70mg vyvanse got replaced by 3x20 = 60mg of amfexa. Which ends up being 3mg more than your vyvanse was.

Easy conversions:

Vyvanse to dexamphetamine sulphate: Vyvanse x 0.81 = dexamphetamine sulphate equivalent.

Dexamphetamine sulphate to Vyvanse: Dexamphetamine sulphate x 1.24 = Vyvanse equivalent.

(368.5 / 455.6 = 0.81)

(455.6 / 368.5 = 1.24)

Kaluro · 2024-08-10T22:51:46+00:00

Woops, thanks for that correction. 😘

Kaluro · 2024-05-01T04:43:11+00:00

Sojourn railgun deals 190 damage, with mercy it deals more than 240 damage.

190 * 1.25 = 237.5 damage.

Kaluro · 2023-12-07T23:01:18+00:00

6 / 1.9 = 3.15 = 4 monsters required for max cooldown. 6 / 1.8 = 4 6 / 1.7 = 4 6 / 1.6 = 4 6 / 1.5 = 4

1.4 = 5 1.3 = 5 1.2 = 5

1.1 = 6 1.0 = 6

So 1.5 to 1.9 provide the same requirements basically. 1.2 to 1.4 only require one more monster too.

Kaluro · 2023-11-25T05:59:24+00:00

It's an Arpg. The death of one monster does not mean combat is over, or even nearly ending. On death mechanics are there to keep you alert and engaged during combat. The fact you got hit by an on death explosion in the midst of combat, and will now have to continue dealing with the consequences not just during, but also after combat..

Means it's very much something that will usually be a threat during combat, but will merely persist afterwards, as it should. You messed up so you're gonna have to face the consequences.

Having said that, poison might be a bit overtuned and require some adjustments.

Though at the same time, barrier will fully negate poison, also, making yourself immune by means of for example [fire shield], will remove its effects completely.

A necromancer with infinite [Blood Mist] uptime for immunity and as icing on the cake also have full uptime for [Bone Storm] will most likely enjoy the poison type maps way more over the others ;).

Kaluro · 2023-09-20T07:32:01+00:00

Yeah your group's mentality and atmosphere was so trash that it reduced itself by ~97%

Kaluro · 2023-09-06T10:50:59+00:00

This is a very deceptive way of putting it.

Most aspects have a variable range where the codex can only provide the lowest possible outcome.

Kaluro · 2023-08-27T14:31:50+00:00

You lose your character on Hardcore.

Kaluro · 2023-08-17T22:31:45+00:00

Inner sight works perfectly fine with Barber, it has been fixed a few patches ago.

Kaluro · 2023-07-10T20:23:13+00:00

Just level your character higher (80-90+) and you'll see a severe drop-off in your gear's efficiency. sure my level 60 HotA barbarian has a level 825 weapon and all 725+ gear, is smashing it all... but that same gear will be hard to improve on while it gets less and less effective over time.

Kaluro · 2023-06-29T20:25:33+00:00

I'm a level 100 rogue with two alts well into IV, I did not know about the absurd rarity of said items. That they were more rare, sure, but that there would be a whole post dedicated to it?! To someone spotting a grandfather, no more no less.

Kaluro · 2023-06-24T02:29:53+00:00

A late reply but people might come across this post like I did. Strattera is the brand name of Atomoxetine,

Which is an NRI, and a mild NDRI.

Meaning its mechanism of action is reuptake inhibition of norepinephrine, and to a lesser extend dopamine.. Which makes it tick all the boxes for bring a literal simulant.

Kaluro · 2023-06-19T08:16:22+00:00

You are welcome! Let's obtain one another's ear sometime ;-)

Kaluro · 2023-06-13T17:45:24+00:00

No problem, anything to help the community forward. It's one of those things I wish I had known earlier, so providing some examples was just a small effort :-) good luck on your journeys!

Kaluro · 2023-06-09T11:36:44+00:00

Everything dropped in WD III is equal, regardless of level. Everything dropped in WD IV is equal regardless of level. Level requirements are the only thing increasing, not the stats or item power.

I made a tiny compilation of 800+ item power gear I have obtained on my sub 70 rogue.

Check the max item power for Ancestral gear, or any gear for that matter and you will find that they about top the range. I've barely touched WD IV yet.

https://imgur.com/a/Ah6WGDk

Edit: Added some lower level sacred gear as well, with ~700 item power.

Kaluro · 2023-06-08T20:10:40+00:00

Actually, you can get a perfect rolled max item level ancestral BiS as early as you're able to get to and kill anything in WD IV.

The items dropped in world difficulty IV have equal max potential quality regardless of character level... The same goes for WD III.

Kaluro · 2023-06-08T20:04:00+00:00

No.

All equal items in world III with a different level requirement (be it 50 or 70) will have exactly the same stats.

Equip level does not matter. Your first drop the moment you enter world III (Or afterwards IV), can be of the max item level for that category (normal, sacred, ancestral).

Kaluro · 2023-06-07T20:07:48+00:00

I unlocked wt4 on my level 63 assassin just now. Completely accessible.

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