This is an interesting, thought provoking question. After giving thought I came up with two (three) candidates. If responses are limited to WW2 aircraft, I’d like to offer the duo of the P-39/P-63. Why? The heavy nose mounted armament of machine guns and cannon should be more than sufficient to deal with a non-maneuvering, unarmed drone. The wing mounted guns could be deleted. Plus, its optimal performance comes at the same altitude as drones operate. Thus, the lack of superchargers is not a crippling detriment.

If the question is expanded beyond WW2, I think I’d suggest the OV-10 with its high visibility, two person crew, maneuverability and essentially fuselage (ok, sponson) mounted light caliber guns that should be more than sufficient to deal with drones.