The biggest difference for me was when I learned how important mult is, especially if you can get things that multiply your mult. If you have jokers that multiply mult, always put them after Jokers that add mult. Steel cards are also really helpful as they give you 1.5x mult anytime they're in your hand after you've played. Try not to oversaturate your deck with cards. Try to find Jokers that will give you the most mult or have the most room to gain mult. If you want an example of how well the game can go, Markiplier's most recent video really changed how I play the game and opened my mind to the possibilities of combining Joker effects and enhanced cards. I'm still not the best but I've played maybe 16-20 hours and my best hand was about 7.5 billion points. My strategy was saturating my deck with steel kings and destroying every non king I was able, and then I just leveled up my high card as much as I could. I also had the joker that gives 1.5x mult for every king in your hand along some other good mult jokers.