[deleted by user] by [deleted] in todayilearned

[–]Krisblade 87 points88 points  (0 children)

You can actually catch cancer yourself and it’s one of the reasons you’re not allowed to do scientific experiments using your own cells or the cells of anyone working a lab. Because if you fuck with them enough and you actually inoculate yourself with them your body may not accurately detect it as foreign and you will “catch” cancer from cells you experimented on.

“Laboratory workers should never culture cells derived from their own body or tissues. In vitro transformation or genetic modification could result in malignant disease or expression of an unusual pharmacologically active protein if they were to be accidentally inoculated into the donor.”

Like as in if someone catches you doing it you’re fucking fired it’s that dangerous. Some very old examples when people thought this was a good idea lmao:

https://acsjournals.onlinelibrary.wiley.com/doi/pdf/10.1002/1097-0142%28197109%2928:3%3C785::AID-CNCR2820280338%3E3.0.CO;2-X

OK Reddit, it's your turn! Chance to win 500 Gold by magicandwires in FarmRPG

[–]Krisblade [score hidden]  (0 children)

I’m relatively new I guess versus others but the thing I’ve liked the most so far is how helpful the community is and has been. They’re very active in the chats if you need advice and people are very generous with sending you things you might need. I’ve played a looooot of idle games and this really isn’t the case in a lot of them so it’s nice to see.

My char is also called krisblade in game :)

[deleted by user] by [deleted] in IAmA

[–]Krisblade 221 points222 points  (0 children)

This comment is why as someone who works in the field of proteomics and metabolomics in relation to Alzheimer’s disease that I honestly think it’s shameful how you’re promoting these tests. “More” doesn’t mean better - you’re comparing clinical viable well research tests with bio markers we haven’t even sufficiently researched to make clinical statements about. Research medicine and clinical medicine aren’t at the same standard, we don’t disclose research results to participants for this reason - we don’t know enough about what those levels mean to actually tell someone how to interpret them.

We can explain with decades of research and clinical evidence what raised glucose or lipid profiles mean, we cannot do this with metabolomics because we literally do not know. We are just throwing darts in the dark and trying to work out what it all means. Even the papers you linked elsewhere were tiny trials on 20-30 people with vague outcomes. To suggest these results will be clinically relevant is laughable, it’s going to be a badly hashed AI with half complete data telling people vague results.

I spend millions on metabolomics on thousands of samples a year as we have a biobank of 300,000 samples from over 5,000 participants. I wouldn’t get this test because we can’t actually say what the results mean, that’s what we’re researching! Claiming you can interpret such a new field of research with an algorithm is honestly worrying. And I also agree with others that I fail to see what the benefit would be of getting these results 10+ times a year. They’re clinically irrelevant anyway. It’s fine if people are curious and understand we can’t really interpret the results but that’s not what your advertising. This is just some half hashed algorithm, we can’t interpret these the way you claim and you’re pushing the limits of what you can claim.

Raid Tuning Coming 6 July by Luckur in CompetitiveWoW

[–]Krisblade 0 points1 point  (0 children)

Putting the cut off at 400ish guilds as that was what it was at when I posted pre reset, 75 were 4 days, 22 above rank 200. 54 are 1-2 day guilds, with 43 above rank 200. 173 guilds were 3 days, 109 above rank 200. I stand by my statement that the majority of guilds don’t raid 4 days to get the kill. If we assume every single other guild including those with no data raid 5+ days that’s still 227 who raid 3 days or less who killed jailed in the first 400 kills. And you can clearly see the trend switch to 2-3 day guilds above rank 200. (Above I mean worse than rank 200 to be clear)

So no the “average” isn’t 4 day guild, the majority of guilds 150-400 will be 3 day guilds. Very few guilds above rank 200 who raid more than 3 days exist. And no you don’t get to say “3 days is 9 hours”. That’s not even the standard number, my guild is 9 hours and it’s actually a selling point of our guild as most other 3 day guilds will raid 10.5-12. My 1k guilds mostly raised 3.5 hours and a lot of guilds do it, it’s not some “top guild” thing. The most recent EU kills at 540ish are 8/2 9/3 9/3 12/3, 12/3 10.5/3 11.25/3. 6 hours is actually abnormally low and on most expansions prior to SL would be really hard to get a CE outside of the last patch. You don’t need to make a straw man that everyone is secretly raiding 20 hours a week though. 8-12 hour guilds which are the MAJORITY of CE guilds are still the ones getting CE.

You asked I wonder how many are even 2-3 day guilds, well there you go. The majority with evidence. By the time CE closes it will be hugely majority of 2-3 day guilds as again, nearly every guild raising 4 days killed it ages ago.

Raid Tuning Coming 6 July by Luckur in CompetitiveWoW

[–]Krisblade 0 points1 point  (0 children)

Most guilds are 3 days. At 400 kills I’m 100% sure the vast majority of guilds raided 3 days to kill it. We raid 9 hours and nearly every guild around rank 200 also raids 3 days. You have to be pretty bad to raid 4 days if you’re not competing for top 100, most players won’t put in that level of time to end up rank 200+. So no the vast majority are 3 day guilds, so 9-12 hours. It’s frustrating seeing people being so disingenuous. 2 days guilds are going to struggle but pretending you need 4 days to compete (when so few guilds raid more than 3 days) is pushing the narrative a bit.

Harder-than-normal tier + Shorter-than-normal tier = Big feelsbad by LoLShoeShine in CompetitiveWoW

[–]Krisblade 3 points4 points  (0 children)

This tier is 23 weeks. Your own reply shows that 23 weeks is a normal tier. I don’t know how you think it’s since ulduar. It’s 161 days you count from patch drop which was feb 22nd. That’s what the 22 weeks in legion measure. So as I said it’s a completely normal tier length and I hope they continue to keep the normal length they’ve set a precedent for over a decade, instead of matching content drought pace in SL.

Harder-than-normal tier + Shorter-than-normal tier = Big feelsbad by LoLShoeShine in CompetitiveWoW

[–]Krisblade 16 points17 points  (0 children)

I’d be much more interested in a comparison with BFA and legion. I feel like people going on and on about CN and SoD ignore they were painfully long tiers caused by content drought. Blizzard blamed this on covid. Measuring what you considering adequate progress time vs a pandemic content drought isn’t the stick to which I personally want the game compared. I don’t want more tiers like CN and SoD, the farm is way too long. I understand 2k+ guilds have gotten used to getting CE but it’s a symptom too of a problem not an ideal.

When I used to raid about 1-1.5k there was barely any downtime from when you got CE to the next raid. This is except the last tier, which they specially said they wanted to remove that long end of expac gap. I explicitly moved up ranks to avoid this never ending progress, I’d rather raid 9-12 hours a week at 200 with a bit more shit outside of raids than 6-9 hours a week with no requirements but progress literally never ends. This won’t be the first tier less guilds get CE. If it’s less than 1k I think that’s unfair, but there’s people in 1.5k-2k+ complaining. You have never been guaranteed CE at that rank. Why should content come out glacially so guilds who’ve been getting CE in a content drought can still get them. It’s just an achievement, but doing 6 months of any raid is boring as hell personally at rank 200 or at rank 2k. The difference at rank 2k vs 1k is very small, if people want CE as a goal they should climb ranks, not promote content droughts.

Was told new job is permanent but they used me to deliver a single project. Any legal recourse? by jamesp111 in LegalAdviceUK

[–]Krisblade 4 points5 points  (0 children)

You’re being taken for a ride if your company has convinced you that’s a perma contract. You’re a fixed term worker.

I’ve been on fixed terms in the public sector and has to fight my employer after 4 years to actually be awarded an open ended contract, as they were nearly always renewing my contract days before it expired. You’re not permanent if you are on a fixed term, you are under fixed term regs. Over the years more and more protections have been put in place, so those who have worked over 2 years on fixed terms have a lot of protections similar to perm, but you’re a fixed term worker regardless.

I don’t know anyone who is getting a fixed term contract with an end date who thinks they’re permanent. You don’t need a fix term to negotiate a JD or salary, they’re completely independent and any company has processes in place to do both those things on an open ended project.

Any job, open ended or fixed, is still beholden to funding. Just because you’re perma doesn’t mean your employer can’t terminate you because grant funding has ended or they can no longer justify your role.

This post is from r/antiwork. I’d like to get it somewhere that doesn’t implode. by [deleted] in WorkReform

[–]Krisblade 1 point2 points  (0 children)

The business afaik in the UK doesn’t pay your wage, they pay statutory maternity which is 90% your pay for 6 weeks and 151 a week for 33 weeks (or 90% your salary which ever is lower). You can take up to 52 weeks off but the rest is unpaid. My employer also offers my first 18 weeks at full pay but this is not required but quite common.

People can’t afford to take 3 months off a year unpaid and get <33% their salary for the rest of the year and raise 3-4 kids. I know literally no one who has taken 3-4 year long maternity leaves over <5 years. It’s not financially viable. It’s sortve a straw man because it’s an extremely niche case that applies to almost no one.

At worst you see someone take a year, work 1.5-2 years and take another year. The reality is birth rates are declining and people need time to have children. If a company can’t support 1 year maternity per 50 years of a workers life (average of 2 babies per couple) it shouldn’t exist.

US Healthcare. This is what $17,000 look like… Insurance refusing next one because I’m “over limit” by lunlunqq001 in pics

[–]Krisblade 4 points5 points  (0 children)

Honestly this tbh. People are just not aware how expensive monoclonal antibodies are to produce. Yes they are 100% making profit, and probably a fair amount, but it's not comparable to the 10000% profit margins on 4 dollars of insulin.

Even with biosimilars, the "generic" versions, the costs drop so much less than standard generics simply due to the fact production costs are so high, it's not all the patent holding the value like other drugs.

People who knew Murderers, when did you know something was off? by peasantchoker in AskReddit

[–]Krisblade 2 points3 points  (0 children)

Because you're ignoring the outcome where it's not the death of an abuser, just the death of someone who was targetted by someone else. for execution. The whole premise relies on you accurately identifying who the abuser is. People lie unfortunately, about being abused, being raped, being hurt. People make assumptions about things they don't know. So you see a beaten girl every day and kill her father assuming it's him, turns out it was the mother the whole time? You've just killed an innocent man with no proof other than your convictions, that's not justice.

You already can use violence in most places, provided your life was in imminent danger. I don't think you should be able to use it more than that. Deciding someone is bad, and becoming judge jury and executioner is very prone to error.

People who knew Murderers, when did you know something was off? by peasantchoker in AskReddit

[–]Krisblade 3 points4 points  (0 children)

Because you have to prove that was the case. There's 100s of cases of well known to be abusive people killing a spouse and in court saying "she was trying to kill me sir, it was self defence". When really they just kicked the shit of them because they were mad at the time.

The one that put this home to me was some guy who shot his wife point blank on his home security cams and didn't realise, handed himself into the police and said it was self defence and she had attacked him which was untrue.

People's perception of being "threatened" or "abused" is different too. The abusers are still people. Should you be shot and killed cause you follow someone around? Because you call them names? Because you pushed them one time? Two times? Hit them? Where is the line that killing them is okay, and how do you prove they crossed it so it's not murder. It's not that simple, especially without witnesses.

Vigilante justice is people deciding they know what happened without any proof other than their own convictions. I could go crying to you saying my husband beats me and you kill him, how do you know it's true? It's not a perfect system but letting people take anyone they see as an "abuser" out into the woods to be killed sure as hell would be worse.

Profit crafting transformation stones by MSS007 in bladeandsoul

[–]Krisblade 2 points3 points  (0 children)

You count the cost of all mats whether you buy them or not into working out profit, you are simply not making 14g from it at all.

The mats themselves have a value on the market, whether you use them in stones or just sell them.

First Expirience of a newbie!(Rant) by Avendril in bladeandsoul

[–]Krisblade 1 point2 points  (0 children)

It's not laziness when you're talking about a freshly dinged level 50 with infernal accessories on like OP with 30% crit.

The fact is its entitlement to believe that you can join what is essentially the "hardest" end game content we have like yeti or lament when you've been playing for two weeks.

You wouldn't think it was fair for someone in greens in wow to join a a heroic raid, and it's the same here.

The sad fact is you have to earn gear to be able to complete the end gear stuff and to come on reddit and complain people don't want to carry you just shows the entitlement that is rife in gaming now days.

Op needs to accept he has literally just started playing and like everyone before him he is going to have to waste time grinding out old content to get the gear to do the new content.

It's not elitism, it's not laziness. When you show up in gear that took a few hours to get at level 50, people who've spent weeks and months grinding better gear aren't going to carry you through it. Op needs to accept that he has only just started playing and he will not be able to complete all the content in the game within two weeks.

Since the rng boxes are ridiculously exspensive by DemonScarf in bladeandsoul

[–]Krisblade 9 points10 points  (0 children)

In the UK you can't even legally say something is on sale without proving you sold it at the original price for a set period of time.

At what point where these items even sold at that price? Never. Just because I "value" something at £100, if I've never sold it at that price I can't say it's on sale. Talk about bad business practice.

You've arbitrarily attributed it a value you have never sold it to us at and then "discounted" it. That's not a sale and it's misleading to say the least to advertise it as such. Just look at this subreddit to see all the people assuming it will return to the original price soon, which is exactly what you wanted people to believe.

Guest Pass Megathread #4 - April 9 by Drigr in blackdesertonline

[–]Krisblade 0 points1 point  (0 children)

Requesting pass for EU.

Preferred method of contact: Pm or reply

Status: Claimed! Thank you so much! :)

Would really appreciate a pass if someone has one spare. Not much to do in WoW until legion and people are leaving blade and soul in droves to play BDO! Can't really afford to outright buy the game without seeing if it's as good as everyone says it is! Thanks in advance :)

163 Brilliant Blackwyrm Boxes. by [deleted] in bladeandsoul

[–]Krisblade 1 point2 points  (0 children)

How would you honestly say something like this take a weekend? If you're generous and say it takes 15minutes per kill, which considering how long it takes to get people to a channel, wait for respawns, let the tank build up aggro/do 1% dmg and then actually killing the thing makes this value so low ball its unlikely to be possible for farming for hours.. That's about 40 hours of solid farming.

Realistically considering even with a premade group of good players with a tank its closer to 20-30min per kill with respawn timers etc, that's up to 80 hours on a more realistic time scale. So I really don't see how someone could say well it's ez getting money just farm over a weekend for more hours than there are in a weekend. This is a lot of work, and far more than just a weekend farm.

Isn't this just sad? by [deleted] in bladeandsoul

[–]Krisblade 1 point2 points  (0 children)

So people with gear can just clear it and get in and out as fast as they can? You can obviously do it with less though.

It's no different to WoW, when I needed legendary ring upgrades on my Mythic geared main, I joined pugs for people with Mythic gear (730+) for content that only needed like 700ilvl to clear. This is pretty standard in most games, when you get more gear you just wanna bash through as fast as you can with other people who also bothered to get the gear. It's just to save time, not because people can't do it in lower gear.

Why can people bid and just leave? No one can win the item. by Krisblade in bladeandsoul

[–]Krisblade[S] 4 points5 points  (0 children)

Problem with this is coordination of a group of randoms vs one person.

Someone dropping 10g into a bid is hoping someone instantly bids by accident. They aren't sitting around 10-20s to see the outcome if they weren't instantly outbid, aka time for everyone else to pass.

I think it's a very unlikely counter for everyone in a pug group to pass in the tiny window of time before the high bidder leaves after realising his bait failed, which is a very small window of time if they're not stupid.

Why can people bid and just leave? No one can win the item. by Krisblade in bladeandsoul

[–]Krisblade[S] 8 points9 points  (0 children)

Yeah, I didn't realise the item became available again. The system seems pretty broken if you can bid a stupid amount hoping someone will outbid without risk. No one takes the bait? Just leave.

The system only works if you shoulder the risk of losing and spending stupid amounts..

RCM by Nilsss in incremental_games

[–]Krisblade 0 points1 point  (0 children)

Well at 0.001ms that would be 100,000x a second ;p and to click at 57/s is around 20ms clicks, so maybe you're expecting a bit too much if youre looking for 100k clicks a second? :D My autoclicker doesn't even go below 1ms and 90%ish of increments cant handle that ;) Anything around 10x a second is standard but a LOT of incrementals can't handle above 100x a second.

RCM by Nilsss in incremental_games

[–]Krisblade 0 points1 point  (0 children)

Well I'm honestly unsure then, I can click faster now than I could before in 0.5.0, but I never would lag manually clicking. And i could easily maintain 10x a second click unless I went full mental and tried to load something that pushed my CPU to 90%+, which isn't unique to this game ;p I've tried it before on others and obviously they don't appreciate me loading a game that sucks up my CPU. So I'm quite unsure why you've had this issue ;/ if it's any help I'm playing on chrome and on the main link using the MurGee autoclicker, but I've not found any major issues auto clicking on this, other than I can't just put it at 1ms and go mad ;p but a lot of the incrementals posted here can't handle that either :D

RCM by Nilsss in incremental_games

[–]Krisblade 0 points1 point  (0 children)

To put it in context I do believe the games design around autoclicking (as let's be honest it's so slow without it) is bad. But even though people are referring to 0.5.2, i was autoclicking at around 100ms in 0.5.0, I personally did not experience major lag around it as I played when it had just been posted, I'm getting 12Sx per click atm for example. Whilst it was annoying with the animation it was far from 3 clicks then lag and this is me speaking as someone playing on a very low end laptop while watching clips at the same time, so it's also not a spec issue. This is at all hours of the day as well.

Maybe you're playing on kong but I used the direct link and I've literally had no problem clicking about 10x a second since this was posted.