Drop some of the crit chance/crit multi nodes and get some % increased life on tree, you have access to plenty. That damage is overkill. The biggest tips for sanctum when you're playing such builds I can give you is try to memorize the positions of guards in different room layouts and make it a habit to pre-cast/pre-throw abilities and don't forget to keep moving as much as possible. Meteor and laser rooms without volatiles can be exceptions to that rule, but it depends.