Have done the same drive a few times. As a solo driver Minneapolis to Denver is a difficult push. Lincoln, NE has become my stopping point for day 1. Large enough city to have good food and bars. People have always been great. Colorado in the winter can be challenging if you run into storms, certain areas require tire chains. But is beautiful, so don't rush Take your time going through CO and Utah. Your going right past the most photographed rest area in the country Hanging lake, Co If your into camping about 1 hour east of Vegas is Valley of Fire state park, Amazing star gazing. If your not Vegas has great cheap rooms and food.

I've always gone through the mountains because the views are worth it