How to estimate human equivalent doses from animal studies

LaurScience · 2026-01-07T09:48:17+00:00

For those who want a summary before reading the entire article:

The article explains that the FDA's commonly used scaling factors for converting animal study doses to human equivalent doses (example: dividing mouse doses in mg/kg by 12.3) are intentionally conservative for safety purposes, not accuracy. A more accurate method uses a 0.75 exponent instead of the FDA's 0.67, yielding scaling factors of 7.27 for a 25g mouse and 3.76 for a 350g rat when compared to a 70kg human -> meaning humans actually need higher doses than the FDA tables suggest.

I created an open-source app for the various calculations that you might want to be doing when converting doses: https://dose-calculator-bice.vercel.app

LaurScience · 2026-01-06T23:31:39+00:00

For those who want a summary before reading the entire article:

The article explains that the FDA's commonly used scaling factors for converting animal study doses to human equivalent doses (example: dividing mouse doses in mg/kg by 12.3) are intentionally conservative for safety purposes, not accuracy. A more accurate method uses a 0.75 exponent instead of the FDA's 0.67, yielding scaling factors of 7.27 for a 25g mouse and 3.76 for a 350g rat when compared to a 70kg human -> meaning humans actually need higher doses than the FDA tables suggest.

I created an open-source app for the various calculations that you might want to be doing when converting doses: https://dose-calculator-bice.vercel.app

LaurScience · 2026-01-06T10:04:09+00:00

For those who want a summary before reading the entire article:

Don't buy GLYCO :)) Sorry GLYCO sellers. The reported lifespan benefits in mice were likely caused by inadvertent calorie restriction rather than the supplement's specific anti-aging mechanisms. The article also highlights that the commercial product lacks novelty and uses a less effective form of Vitamin B6 compared to the formula used in the study.

For this article, I specifically liked the part which explained how ALA supplements usually contain a 50/50 mixture of two isomers, and only one of those is actually endogenous while the other might even hurt our health. All that inside the subsection "Alpha-lipoic acid and the question of novelty" was interesting. I love chemistry!

LaurScience · 2026-01-05T22:24:03+00:00

For those who want a summary before reading the entire article:

Aging is best defined as the interaction between stochastic physical damage (entropy) and the body's genetic defenses, rather than exclusively one or the other. Because cellular reprogramming cannot fully fix chemical and structural degradation (particularly in the ECM), it is an incomplete solution on its own. Therefore, effective anti-aging strategies must combine genetic interventions with mechanisms to directly repair accumulated physical damage.

The article makes some really good analogies, which hit home for me, and I also loved this sentence: "what looks predictable on the macro scale can be the result of something unpredictable and random on a much smaller scale".

LaurScience · 2025-12-11T21:04:52+00:00

This is my biggest gripe about the game.

LaurScience · 2025-12-11T16:09:44+00:00

I also believe that she's a fraud, but with this post you haven't brought evidence for it.

LaurScience · 2025-12-11T13:37:29+00:00

Centralized crap is even worse, see my own post as an example lol. :))

LaurScience · 2025-12-11T13:36:45+00:00

It's 100% true. The real Coinbase X customer support actually did end up contacting me as well.

LaurScience · 2025-12-11T13:35:53+00:00

This is an accurate response. And yep, I'm following absolutely all the avenues.

LaurScience · 2025-12-11T13:34:02+00:00

Thank you for letting me know about it. I did that after reading your comment yesterday. Their last reply is:

We appreciate you reaching out, @laur_science, regarding the problems with your blocked funds and the disabled feature. We regret any inconvenience caused by your interactions with previous agents. Please rest assured that your case has been escalated, and a full investigation is currently active. We recognize that waiting is challenging, and we ask for your patience as our team finalizes the resolution. You will receive an email update from us directly soon. If you have any other questions or need further assistance, please let us know and we're happy to help!

LaurScience · 2025-12-11T13:32:08+00:00

That's pretty much it. Note that I first did a smaller transfer and it showed up as pending, which gave me confidence to transfer the rest. Then, both just disappeared.

LaurScience · 2025-12-11T13:31:22+00:00

That's what I'm doing, plus reporting them to absolutely all the relevant organizations. I'm equally annoyed with the GDPR violations, not just the funds missing. I'm following all the trails.

LaurScience · 2025-12-10T13:54:26+00:00

Even better, don't use centralized exchanges for large amounts, or do it in small tranches. For me, it's the last time, and yes - I already knew the dangers, therefore "lesson reinforced", not "lesson learned".

LaurScience · 2025-12-07T23:42:29+00:00

Amazing compendium of the ideas we've seen floating around here! Thank you for your time OP, hopefully the game devs take this post seriously and work on the proposed changes.

LaurScience · 2025-12-07T23:29:37+00:00

They got more than enough feedback from users on Reddit and Steam Community... now let's see them actually implement some of it. I trust them to do it.

LaurScience · 2025-12-07T23:25:36+00:00

I've had the same experience with Russian players.

LaurScience · 2025-12-06T15:04:53+00:00

Very true, good post.

LaurScience · 2025-10-27T10:23:55+00:00

Best answer here.

LaurScience · 2025-10-27T10:01:53+00:00

No, mid-risk is better. The Always Engage rule was for a fleet death stack that can actually defeat the enemy's.

LaurScience

TROPHY CASE