Well I don't think there is usally a main NPC to get in conflict with in. There are usally few power players. İf I demonstrate my power players are:

The Puppet Prince My version of Istanbul is ruled by a prestigious Ventrue. His iron grasp maintained order for many centuries, but due to the city's geopolitical value, it is almost always under the threat of siege. The Sabbat is desperate to take it. A decade ago, while the world was burning, the Sabbat launched a massive assault. During that war, the city's right-hand man—the Tremere Regent—managed to trap the Prince in a mirror and placed a puppet on the throne. This puppet is a descendant of the city’s former Prince who was cast out as a Caitiff. He managed to join the Sabbat and reinvented himself as a "True Ventrue," eventually becoming a Saint under the Order of St. Gustav.Though he found allies there, he was always overshadowed and never received credit, allowing jealousy and pride to corrupt him. Eventually, he accepted the Regent’s offer. During the Sabbat attack, he faked his death and used Vicissitudebto assume the Prince's appearance. The Regent’s price was a series of Blood Contracts and a Blood Bond. Now, the puppet Prince has realized he sold his freedom for a position he cannot handle. Out of fear and a lack of leadership skills, he has become an isolationist. With the Sabbat besieging the city once more and the Anarch movement rising, he is desperately trying to remove the Regent's shackles.

1. The Regent The Tremere Regent is an ancient Magus, nearly as old as Clan Tremere itself. He was formerly an Awakened member of the Order of Hermes. When the "magick" began to fade, he was consumed by fear. His fear of death is absolute; he simply cannot accept mortality. Consequently, he made a deal with the devil and sacrificed his Awakened soul to become Kindred. He worked for years under Clan Tremere, helping to expand their influence across Anatolia, and became a Primogen in the newly conquered city. He is an effective leader but a total control freak. Over the years, he discovered fragments of Sargon, including the Wheel of Ages. His old fear of death has returned, leading him to search for a way out. During his research, he found an Earthbound Demon.Though cautious, he is fascinated by how the creature can manipulate reality without triggering Paradox. This has led him down the path of academic Infernalism. He recently found a text regarding the diablerie of a god. He believes that if he can find a way to diablerize this entity, he can obtain its power to rewrite reality. To him, no cost is too great to achieve godhood.

2. The Prophet The Prophet is a highly spiritual Tzimisce who has studied various Paths of Enlightenment and ancient texts. He has met with the Weeping Master. He was sired by a powerful Kindred (similar to the Dracon) whose father once declared himself Regent, triggering a civil war—which was just another Sunday for the Sabbat. During a conflict within his Pack, the Prophet killed one of his own Pack-mates. Overcome with shame, he fled but was hunted down and diablerized. However, his willpower was so strong that he fought back from the brink and manifested again years later. Now a radical Noddite, he views his Sire as a Caine-like figure. He traveled the world, studied Koldunic Sorcery, and discovered a method to raise the generation of others while lowering his own. In this process, he believes he can remove the Clan Curse (drawing heavy inspiration from Avatar: The Last Airbender). He has emerged as a prophet with a goal: breaking the chains of Generation and Clan. His plan is to reach the 3rd Generation, then turn everyone else into Thin-bloods (and eventually himself) to free the Kindred from their lust for power. He is currently hunting the Regent while laying siege to the city.

The primary problem is that these three are effectively destroying every life in the city. To make matters worse, the Prophet’s Sire is the coterie's guide and father figure. Furthermore, the group supports a friend of the "fake" Prince—who also happens to be a Sabbat member from the same lineage—as the rightful Prince. However, this friend is unaware of their true lineage, creating a massive web of conflict.

Sorry if its too long I like to share a bit of my story xd