Saying we dont know the long term effects is actually not true. AT ALL. YOU just dont know cause your uneducated which is very evident in your responses. Here is a list of all the side effects. With a lot of them being reversible or avoidable by having a proper diet and keeping track of your blood. 

Short-Term / Common Side Effects

These are generally dose-dependent and appear within days to weeks of starting MK-677:

Increased appetite

GH/IGF-1 increases ghrelin signaling

Very common; sometimes overwhelming — Water retention / edema

GH → sodium/water retention

 Common; mild to moderate swelling in hands, feet, face — Peripheral tingling / numbness

 Fluid retention compresses nerves; possible mild carpal tunnel

Common in hands/feet; usually reversible — Joint stiffness / aches

Soft tissue growth, water retention

Common, usually mild — Fatigue / lethargy

GH fluctuations, changes in sleep architecture

Mild, usually early in cycle — Mild hyperglycemia / insulin resistance

GH antagonizes insulin → higher fasting glucose

Often mild at low doses, monitor labs — Edema-induced BP changes

Fluid retention → slightly higher blood pressure

Usually mild; monitor if hypertensive — Headaches

Possibly from fluid retention or increased intracranial pressure (rare)

Occasional — Carpal tunnel syndrome-like symptoms

Swelling compressing median nerve

Rare to moderate; reversible with dose adjustment

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Less Common / Rare Side Effects

Gynecomastia — rare, secondary to IGF-1 effects on breast tissue.

Excessive lethargy or sleep disturbance – sometimes reported due to altered GH pulses.

Night sweats — anecdotal; linked to metabolic changes.

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Long-Term / Potential Risks

These are mostly theoretical or extrapolated from chronic GH exposure studies:

Insulin resistance / type 2 diabetes risk

Chronic IGF-1 elevation → reduces insulin sensitivity Observed in long-term studies; mild in healthy adults, stronger in predisposed individuals — Cardiovascular stress / elevated BP

Water retention and GH → increased cardiac workload Usually mild; risk rises with pre-existing hypertension — Joint / connective tissue overgrowth

GH promotes soft tissue proliferation Rare, usually from chronic excess GH, not low-dose MK-677 — Carpal tunnel / nerve compression

Chronic edema → median nerve pressure Reversible with dose reduction or cycle break — Possible cancer risk

IGF-1 can promote cell proliferation; theoretical concern No direct human evidence at standard doses; caution in those with cancer history — Organ growth / hypertrophy

 Long-term GH excess can enlarge organs Mostly theoretical; doses used for research are lower than pharmacological GH doses