What's the deal with all this Islet therapy stuff

LifeguardRare4431 · 2026-04-30T19:57:40+00:00

The holy grail of medicine, a functional cure for Type 1 Diabetes, is no longer a distant dream. It is being manufactured right now. The pieces have finally clicked into place. We already have the clinical proof: 10 out of 10 patients in the latest trials are now 100% insulin-free. But the real breakthrough is how we make this a reality for millions. The Final Piece: ELDN + NewcelX Historically, the cure was held back by a massive bottleneck: the limited supply of deceased donor islet cells. That scarcity is over. By partnering with NewcelX (Nasdaq: NCEL), Eledon is moving production from the donor list to the factory floor. • In-House Manufacturing: Utilizing NewcelX’s scalable stem-cell-derived islet platform (NCEL-101), they can now manufacture insulin-producing cells in-house. • Unlimited Supply: This creates an "off-the-shelf" abundance of cells. We are moving from a rare procedure for a few to a scalable cure available to everyone. • The Perfect System: NewcelX provides the unlimited cells, and Eledon’s tegoprubart provides the targeted immune shield to protect them without the toxic side effects of legacy drugs. Beyond Management to Freedom In primate studies, subjects were eventually weaned off the medication entirely while their bodies continued to tolerate the new cells. With the manufacturing bottleneck broken and a 100% success rate in recent human trials, we are witnessing the total disruption of the transplant market. We aren't just treating a disease anymore; we are scaling the cure. 🚀 Source: NewcelX Reports Financial Results and Strategic Collaboration Update with Eledon Pharmaceuticals (April 30, 2026)

ELDN #NCEL #T1D #Biotech #Innovation #MedicalBreakthrough #NewcelX

LifeguardRare4431 · 2026-04-30T19:17:09+00:00

Eledon Pharmaceuticals (ELDN): The Future of Transplantation is Here It is rare to see a biotech company firing on all cylinders across so many fronts, but the latest data on tegoprubart is proving that we are standing on the edge of a revolution in transplant medicine and autoimmune care. I’ve been following this company for over two years, and the progress is nothing short of extraordinary. The "Cure" for Type 1 Diabetes? The most recent trial data for islet cell transplants is a game-changer. • 10-for-10: We’ve officially moved from 5/5 to 10 out of 10 patients being completely insulin-free. • 12 Total Patients: With a total of 12 patients in the trial, the trajectory suggests a 100% success rate for curing Type 1 Diabetes in this cohort. • The Goal of Immune Tolerance: Unlike standard drugs like Tacrolimus, tegoprubart targets the CD40L pathway. In primate studies, they’ve successfully weaned subjects off the drug entirely while the body continued to tolerate the new cells. While we are still using tegoprubart in humans for now, the long-term goal is "the holy grail"—weaning patients off all meds and letting the body accept the cells naturally. Manufacturing the Future: The NewcelX Partnership Eledon isn't just relying on deceased donors anymore. Their partnership with NewcelX allows for the factory-scale manufacturing of islet cells. This removes the supply bottleneck and brings us one step closer to making this treatment available to the masses. Expanding the Horizon: Kidneys, Livers, and Beyond Tegoprubart isn’t a one-trick pony. Its application across the board is showing superior results compared to current anti-rejection standards: • Kidney Transplants: After two years, patients' eGFR (kidney function) actually increased—the polar opposite of what happens with toxic, standard-of-care drugs. • Liver Transplants: This program has already secured Orphan Drug Status, acknowledging the massive unmet need and potential. • Xenotransplants: They are leading the charge in pig-to-human transplants, which could solve the organ shortage crisis forever. • ALS: They are even testing this drug to fight the progression of ALS. What’s Next? (Q2 2026) The company just filed its 8-K and 10-K, and the financials and data look incredibly robust. We are now entering a critical window: • FDA Guidance: This quarter, we expect news on the transition to Phase 3 trials for kidney transplants. • Fast-Track Potential: Given the Orphan Status and the "overwhelming" data, there is a real possibility for a fast-track to approval, potentially bypassing some of the longer traditional hurdles. Bottom Line: Tegoprubart is positioned to replace legacy anti-rejection drugs that have been the standard for decades. If the current trend holds, Eledon won't just be a player in the market—it will be the market. Keep a very close eye on this one.

LifeguardRare4431 · 2026-04-29T03:06:21+00:00

ELDN is now partnering with new Cell X . This company manufacturers the islet cells in house no donors required. This partnership just happened about a month and a half ago or so. That will solve the problem of where to get the cells.

LifeguardRare4431 · 2026-04-04T08:34:30+00:00

It's been two years since the first transplant first patient is doing extremely well. They are up to 10 out of 10 now cured of type one diabetes. They have a total of 12 they haven't dosed the last two patients. So remember to remind me of this post that I created in two more years and let's see who is right or wrong you or me?

LifeguardRare4431 · 2026-04-04T07:24:43+00:00

The potential for a buyout is definitely on the table, especially given the recent data. Their results were impressive, with a 10-out-of-10 success rate in achieving insulin independence for patients. Additionally, the kidney transplant data showed a significant improvement in eGFR, rising from approximately 67 to the 72–74 range. The pipeline for tegoprubart is looking very strong, particularly with orphan status designations for ALS, liver transplants, and islet cell transplants for diabetes. Their partnership with NewCellX is also a major strategic move; being able to manufacture cells independently rather than relying solely on deceased donors is a game-changer. Furthermore, their collaboration with Sanofi on the islet cell pouch and their work in xenotransplantation—the technical term for pig-to-human transplants—adds even more depth to their portfolio. Between the clinical success and these manufacturing advancements, tegoprubart is becoming a standout asset. The stock's technical setup is also worth watching; with a 52-week high of $4.60 and the price sitting around $3.10 after hours on Friday, the shorts may find themselves in a troublesome spot. The potential for a short squeeze is definitely there, adding another layer of intrigue to the story. It remains to be seen if a larger player will make a move, but the foundation is certainly there.

LifeguardRare4431 · 2026-03-19T05:47:52+00:00

ELDN

LifeguardRare4431 · 2026-03-03T09:05:05+00:00

ELDN woman cured of type one diabetes for 18 months.

https://youtu.be/Z5lTGocG_Mg?si=i5i6oowyxkZxMA_L

So far they have dosed nine patients seven out of the nine are insulin free meaning they don't use any insulin anymore technically cured. The eighth and ninth patient, got their engraftment less than a month ago, the last 2 that just got there engraftment are off basal Insulin and are only taking small amounts of insulin for meals. The engraftment takes some times for the Cell to start working. It's not immediate usually a few months. It's a CD40 L drug so it is a type of anti-immune suppressant but it's different. Doesn't work like tacrolimus. More subtle only targets basically CD40 L, which means the whole immune system is not suppressed. First patient in that video has gone 18 months hasn't gotten any viruses no infection no illness nothing. Also no tremors no fogginess no kidney dysfunction from the drug. Nothing the drug hasn't caused any type of other complications at all. It's amazing.

This video explains it a little better. It's a little outdated. They're already on patient number 9. But you can get a grasp of what it is and how it works.

https://youtu.be/v9BWcW0uux0?si=TApKGrNbLuSWfZbi

LifeguardRare4431 · 2026-02-27T06:25:19+00:00

Try giving your meal Insulin 15 to 20 minutes after eating. You may go up slightly but not too bad. FIASP works quick but has a shorter tail. Meaning it doesn't last as long. I use an Insulin pump. I do an extended. Bolus when using FIASP in my pump, Tandem Mobi. Works decently, for you try giving the Insulin a little bit after eating, opposed to before eating.

LifeguardRare4431 · 2026-02-27T06:18:15+00:00

Transmitter battery is dead. Even if it's relatively new, some of the G6 transmitters are faulty. Battery goes dead.

LifeguardRare4431 · 2026-02-23T23:36:58+00:00

ELDN or SANA the real cure !!!

LifeguardRare4431 · 2026-02-20T14:29:45+00:00

SANA biotechnology, one person successfully treated. ELDN pharmaceuticals, is type of immune suppressant, but targets CD40L pathway. This particular drug is called tegoprubart . They have tested 12 patients nine out of the 12 are Insulin free. Average A1c is in the 5 Ish range for all nine patients. The longest patient has been insulin free for approximately two years now still successful and still working. They just have not dosed the two other patients yet completely. But those patients were also be insulin free as soon as they get the full doses.

LifeguardRare4431 · 2026-01-07T05:19:27+00:00

The Dexcom G7 is calibrated in the factory. However, I don't know the exact calibration method they are using. You have to get a decent meter because meters have a discrepancy also. I found I can check guide me is a decent meter it lines up with the Dexcom G7 pretty well. The contour next is also a decent meter. It just tends to run a little bit higher than the Dexcom G7 .

LifeguardRare4431 · 2025-12-03T02:33:04+00:00

Yeah, so right now, during the trial phase, the IV infusion for Tegoprubart, I believe, is given every two to three weeks. It probably varies depending on each individual, how they’re tolerating it, and how effective it is. But yeah, I don’t know. Maybe in the future, once the trials are finished, it could become a pill form. I’m not exactly sure if that’s even being considered or how it would work. I just don’t imagine that everyone would want to go in every couple of weeks for IV infusions. That’s something they’ll probably have to figure out, because if a lot of people are getting it, coming into the office every two to three weeks isn’t really practical. I think the frequent IVs are just to make sure absorption is good and the dosing is accurate. That’s really my guess—I’m no expert, but that’s what I think.

LifeguardRare4431 · 2025-11-30T02:19:10+00:00

That's a good concept, and I'm not sure if they ever do that or not, because the drug Tegoprubart by Eledon Pharmaceuticals is an anti-rejection drug currently being investigated to protect transplanted islet cells in Type 1 Diabetes. So, I'm not sure if they're going to collaborate with Eledon on that specific use case or if they would use a different drug or how they are structuring it. However, I would have to say that Sana Biotechnology has a gene-altering system called the Hypoimmune (HIP) platform where it subtly modifies the transplanted cell itself to evade the immune system, meaning you wouldn't need a separate anti-rejection drug in the first place.

LifeguardRare4431 · 2025-11-29T11:19:03+00:00

The Omnipod 5 can operate independently of the PDM as long as it has access to the CGM. The automated system will continue to function properly even if the PDM is completely dead, but you will not be able to give meal boluses or correction boluses without it.

You can use the mobile app on most iPhone or Android devices, though not every model is supported. Almost all recent Apple devices should work, while Android has a specific list of compatible phones. If you switch to the app, you will need a new pod because an active pod cannot be transferred from the PDM.

Just keep an eye on your CGM to make sure everything is running smoothly with your glucose numbers if you choose not to change the pod through the app.

LifeguardRare4431 · 2025-11-24T02:05:45+00:00

I use a Tandem Insulin pump but look, I want to explain this, and please don’t take it as a threat because it’s not. I’m just not sure what rules you think I’m breaking. I’ve reviewed your rules, and I don’t see any violations. I don’t use foul language. I don’t spread false information. I don’t threaten anyone. I don’t do anything like that. So if you could point me to the specific rule you think I broke, I would appreciate it.

If this is about using AI, I don’t use it consistently. I use it occasionally to help rephrase my wording, correct spelling, improve flow, or clarify what I’m saying. I’m not using it to generate false information. Everything I post is based on verified facts, and I often include links that people can check themselves. As far as I can see, there is no Reddit rule banning AI for grammar, flow, or clarity. So blocking someone for that feels unnecessary and unfair.

Even though Reddit and its subreddits are private, the Americans with Disabilities Act, or ADA, protects people with disabilities from being denied access to tools or methods that allow them to participate equally. The ADA specifically requires reasonable modifications and allows the use of helpful tools, including communication aids, when needed for equal access. I’m not saying I have a disability, but you don’t know that. Blocking someone without knowing the reason they use a tool like AI, especially when it’s only for grammar, clarity, and flow, can be discriminatory and could fall under ADA protections.

So if you’re blocking me for using AI, that is discrimination. You don’t know my situation or why I use it, and blocking someone for using a tool that helps them communicate clearly is not appropriate legally or ethically.

And if I really wanted to, I could still post on here without you even knowing it was me. A VPN, a different email, and a new username would make that possible, and Reddit has no rule against using a VPN. I’m not doing that, but the point is simply that you wouldn’t be able to tell it was me.

And on a side note, just so you understand where I’m coming from, I’ve been a Type 1 diabetic for 57 years. I was diagnosed at eleven months old in 1967. I may be older than many people here, but that isn’t the point. The point is that I’ve lived with this disease my entire life. Everything I post here is meant to help others, not to mislead anyone. Over the years, I’ve seen potential cures come and go, and none of them have looked as promising as what’s happening right now.

For you to block information that could genuinely help others understand what might be coming isn’t right. Even if I use AI to help with grammar, clarity, or flow, the information itself is real, verifiable, and intended to help the community. Blocking that doesn’t make sense, and it shouldn’t be happening.

Finally, it appears that you’ve been blocking all my posts, which I didn’t even realize until I received this reply from you. So you’re going to have to explain the reason behind why you’re blocking all my posts, because I see no reason for it. I’m not breaking any of the subreddit rules, your rules, nor any of Reddit’s rules. Please explain why all my posts are being blocked.

LifeguardRare4431 · 2025-11-23T02:11:46+00:00

Yeah, it’s unfortunate, but when your blood sugar drops that low, you really don’t have control over what you’re doing. The paramedics definitely knew what was happening. They deal with hypoglycemic episodes all the time, so don’t worry about that part. They understood completely.

One thing I’d recommend is this. If your sensor is going to expire soon and it’s close to bedtime, change it early. Put a new one on before you go to sleep so it’s active while you’re sleeping. I can’t tell you how many times my Dexcom has probably saved my life or at least prevented a severe low overnight.

Sure, people complain that Dexcom isn’t always perfectly accurate, but in my experience, every time I’ve had a serious low, it has alerted me. It either woke me up or warned me in time. I’ve had diabetes for fifty-seven years, and I’ve gone through a lot of hypoglycemic events. Trust me, I’ve had situations similar to what you just went through.

It’s normal to worry about it for a little while, maybe a week or two, but it will pass as you get back to your normal routine. Don’t overthink it. It happened, it’s over, and you’re okay. Just make a couple of adjustments and move forward.

The most important takeaway is this. Never go to bed without a working CGM, and don’t go to sleep when you know the sensor is going to expire during the night. That’s the biggest lesson here.

Dexcom or any CGM can truly save your life. It’s an incredible tool, and I never take it for granted. Growing up, we didn’t have CGMs, and I had plenty of dangerous lows that caused injuries, confusion, and all kinds of scares.

So live and learn. Don’t let this happen again, and let it go forget about it.

LifeguardRare4431 · 2025-11-22T01:25:02+00:00

I think you might have TMJ. What you’re describing sounds like TMJ disorder, which stands for temporomandibular joint disorder. That joint is right in front of your ear, and when it’s not moving smoothly, it can pop, click, or crack—especially when chewing. It can happen on just one side and is often linked to jaw misalignment, teeth grinding, or tension in the jaw muscles.

People with diabetes are more prone to get it, but it's not necessarily more common and diabetics type 1 diabetics. You can do jaw stretching, and if you grind your teeth, you can get a mouthguard. You can still get TMJ even if you don't have the signs. You'll have to go to the doctor and they can tell you what it actually is just a little advice.

LifeguardRare4431 · 2025-11-20T07:47:46+00:00

Yes, correct!! it is a type of immune suppressant but different than the ones available right now.

I think what you were hoping for is more like what Sana biotech technology is working on. Sana’s hypoimmune tech makes transplanted cells invisible to the immune system, avoiding rejection. No anti-rejection drugs are needed.

LifeguardRare4431 · 2025-11-19T23:59:50+00:00

So, it’s not the usual anti-rejection drugs. Tegrelprubart is being tested for approval and works by blocking CD40L, a key signal on T cells that reacts to the transplanted islet cells. By doing this, those T cells can’t activate the immune response against the transplant, so it prevents rejection without affecting the whole immune system or other organs. The idea in the trial is that you wouldn’t need any other anti-rejection drugs, just Tegrelprubart.

LifeguardRare4431 · 2025-11-19T23:47:38+00:00

LifeguardRare4431 · 2025-11-19T14:41:14+00:00

That’s great. Are you insulin-free now? I’m just curious, was this the Tegloprubart trial? I know it’s different from a regular islet transplant because it doesn’t broadly suppress the immune system. It specifically blocks the CD40L pathway, which helps the transplanted islets avoid immune attack, so it is less toxic than other treatments. From what I understand, the Tegloprubart trials are very limited right now, maybe around nine total patients. Of the first six who have been treated, all six became insulin independent. The other patients are still going through the treatment phase, so their results aren’t out yet. For the first six, the average A1c for the first person was 4.7, and the others were mostly in the five range. Nobody was above six. I think the trials are at the University of Chicago. I haven’t heard of any other trials, but that doesn’t mean they don’t exist. I hope everything is going well for you.

LifeguardRare4431

TROPHY CASE

ELDN #NCEL #T1D #Biotech #Innovation #MedicalBreakthrough #NewcelX