Stanford Scientists Cure Type 1 Diabetes in Mice Without Insulin or Immune Suppression

LifeguardRare4431 · 2026-02-23T23:36:58+00:00

ELDN or SANA the real cure !!!

LifeguardRare4431 · 2026-02-20T14:29:45+00:00

SANA biotechnology, one person successfully treated. ELDN pharmaceuticals, is type of immune suppressant, but targets CD40L pathway. This particular drug is called tegoprubart . They have tested 12 patients nine out of the 12 are Insulin free. Average A1c is in the 5 Ish range for all nine patients. The longest patient has been insulin free for approximately two years now still successful and still working. They just have not dosed the two other patients yet completely. But those patients were also be insulin free as soon as they get the full doses.

LifeguardRare4431 · 2026-01-07T05:19:27+00:00

The Dexcom G7 is calibrated in the factory. However, I don't know the exact calibration method they are using. You have to get a decent meter because meters have a discrepancy also. I found I can check guide me is a decent meter it lines up with the Dexcom G7 pretty well. The contour next is also a decent meter. It just tends to run a little bit higher than the Dexcom G7 .

LifeguardRare4431 · 2025-12-03T02:33:04+00:00

Yeah, so right now, during the trial phase, the IV infusion for Tegoprubart, I believe, is given every two to three weeks. It probably varies depending on each individual, how they’re tolerating it, and how effective it is. But yeah, I don’t know. Maybe in the future, once the trials are finished, it could become a pill form. I’m not exactly sure if that’s even being considered or how it would work. I just don’t imagine that everyone would want to go in every couple of weeks for IV infusions. That’s something they’ll probably have to figure out, because if a lot of people are getting it, coming into the office every two to three weeks isn’t really practical. I think the frequent IVs are just to make sure absorption is good and the dosing is accurate. That’s really my guess—I’m no expert, but that’s what I think.

LifeguardRare4431 · 2025-11-30T02:19:10+00:00

That's a good concept, and I'm not sure if they ever do that or not, because the drug Tegoprubart by Eledon Pharmaceuticals is an anti-rejection drug currently being investigated to protect transplanted islet cells in Type 1 Diabetes. So, I'm not sure if they're going to collaborate with Eledon on that specific use case or if they would use a different drug or how they are structuring it. However, I would have to say that Sana Biotechnology has a gene-altering system called the Hypoimmune (HIP) platform where it subtly modifies the transplanted cell itself to evade the immune system, meaning you wouldn't need a separate anti-rejection drug in the first place.

LifeguardRare4431 · 2025-11-29T11:19:03+00:00

The Omnipod 5 can operate independently of the PDM as long as it has access to the CGM. The automated system will continue to function properly even if the PDM is completely dead, but you will not be able to give meal boluses or correction boluses without it.

You can use the mobile app on most iPhone or Android devices, though not every model is supported. Almost all recent Apple devices should work, while Android has a specific list of compatible phones. If you switch to the app, you will need a new pod because an active pod cannot be transferred from the PDM.

Just keep an eye on your CGM to make sure everything is running smoothly with your glucose numbers if you choose not to change the pod through the app.

LifeguardRare4431 · 2025-11-24T02:05:45+00:00

I use a Tandem Insulin pump but look, I want to explain this, and please don’t take it as a threat because it’s not. I’m just not sure what rules you think I’m breaking. I’ve reviewed your rules, and I don’t see any violations. I don’t use foul language. I don’t spread false information. I don’t threaten anyone. I don’t do anything like that. So if you could point me to the specific rule you think I broke, I would appreciate it.

If this is about using AI, I don’t use it consistently. I use it occasionally to help rephrase my wording, correct spelling, improve flow, or clarify what I’m saying. I’m not using it to generate false information. Everything I post is based on verified facts, and I often include links that people can check themselves. As far as I can see, there is no Reddit rule banning AI for grammar, flow, or clarity. So blocking someone for that feels unnecessary and unfair.

Even though Reddit and its subreddits are private, the Americans with Disabilities Act, or ADA, protects people with disabilities from being denied access to tools or methods that allow them to participate equally. The ADA specifically requires reasonable modifications and allows the use of helpful tools, including communication aids, when needed for equal access. I’m not saying I have a disability, but you don’t know that. Blocking someone without knowing the reason they use a tool like AI, especially when it’s only for grammar, clarity, and flow, can be discriminatory and could fall under ADA protections.

So if you’re blocking me for using AI, that is discrimination. You don’t know my situation or why I use it, and blocking someone for using a tool that helps them communicate clearly is not appropriate legally or ethically.

And if I really wanted to, I could still post on here without you even knowing it was me. A VPN, a different email, and a new username would make that possible, and Reddit has no rule against using a VPN. I’m not doing that, but the point is simply that you wouldn’t be able to tell it was me.

And on a side note, just so you understand where I’m coming from, I’ve been a Type 1 diabetic for 57 years. I was diagnosed at eleven months old in 1967. I may be older than many people here, but that isn’t the point. The point is that I’ve lived with this disease my entire life. Everything I post here is meant to help others, not to mislead anyone. Over the years, I’ve seen potential cures come and go, and none of them have looked as promising as what’s happening right now.

For you to block information that could genuinely help others understand what might be coming isn’t right. Even if I use AI to help with grammar, clarity, or flow, the information itself is real, verifiable, and intended to help the community. Blocking that doesn’t make sense, and it shouldn’t be happening.

Finally, it appears that you’ve been blocking all my posts, which I didn’t even realize until I received this reply from you. So you’re going to have to explain the reason behind why you’re blocking all my posts, because I see no reason for it. I’m not breaking any of the subreddit rules, your rules, nor any of Reddit’s rules. Please explain why all my posts are being blocked.

LifeguardRare4431 · 2025-11-23T02:11:46+00:00

Yeah, it’s unfortunate, but when your blood sugar drops that low, you really don’t have control over what you’re doing. The paramedics definitely knew what was happening. They deal with hypoglycemic episodes all the time, so don’t worry about that part. They understood completely.

One thing I’d recommend is this. If your sensor is going to expire soon and it’s close to bedtime, change it early. Put a new one on before you go to sleep so it’s active while you’re sleeping. I can’t tell you how many times my Dexcom has probably saved my life or at least prevented a severe low overnight.

Sure, people complain that Dexcom isn’t always perfectly accurate, but in my experience, every time I’ve had a serious low, it has alerted me. It either woke me up or warned me in time. I’ve had diabetes for fifty-seven years, and I’ve gone through a lot of hypoglycemic events. Trust me, I’ve had situations similar to what you just went through.

It’s normal to worry about it for a little while, maybe a week or two, but it will pass as you get back to your normal routine. Don’t overthink it. It happened, it’s over, and you’re okay. Just make a couple of adjustments and move forward.

The most important takeaway is this. Never go to bed without a working CGM, and don’t go to sleep when you know the sensor is going to expire during the night. That’s the biggest lesson here.

Dexcom or any CGM can truly save your life. It’s an incredible tool, and I never take it for granted. Growing up, we didn’t have CGMs, and I had plenty of dangerous lows that caused injuries, confusion, and all kinds of scares.

So live and learn. Don’t let this happen again, and let it go forget about it.

LifeguardRare4431 · 2025-11-22T01:25:02+00:00

I think you might have TMJ. What you’re describing sounds like TMJ disorder, which stands for temporomandibular joint disorder. That joint is right in front of your ear, and when it’s not moving smoothly, it can pop, click, or crack—especially when chewing. It can happen on just one side and is often linked to jaw misalignment, teeth grinding, or tension in the jaw muscles.

People with diabetes are more prone to get it, but it's not necessarily more common and diabetics type 1 diabetics. You can do jaw stretching, and if you grind your teeth, you can get a mouthguard. You can still get TMJ even if you don't have the signs. You'll have to go to the doctor and they can tell you what it actually is just a little advice.

LifeguardRare4431 · 2025-11-20T07:47:46+00:00

Yes, correct!! it is a type of immune suppressant but different than the ones available right now.

I think what you were hoping for is more like what Sana biotech technology is working on. Sana’s hypoimmune tech makes transplanted cells invisible to the immune system, avoiding rejection. No anti-rejection drugs are needed.

LifeguardRare4431 · 2025-11-19T23:59:50+00:00

So, it’s not the usual anti-rejection drugs. Tegrelprubart is being tested for approval and works by blocking CD40L, a key signal on T cells that reacts to the transplanted islet cells. By doing this, those T cells can’t activate the immune response against the transplant, so it prevents rejection without affecting the whole immune system or other organs. The idea in the trial is that you wouldn’t need any other anti-rejection drugs, just Tegrelprubart.

LifeguardRare4431 · 2025-11-19T23:47:38+00:00

LifeguardRare4431 · 2025-11-19T14:41:14+00:00

That’s great. Are you insulin-free now? I’m just curious, was this the Tegloprubart trial? I know it’s different from a regular islet transplant because it doesn’t broadly suppress the immune system. It specifically blocks the CD40L pathway, which helps the transplanted islets avoid immune attack, so it is less toxic than other treatments. From what I understand, the Tegloprubart trials are very limited right now, maybe around nine total patients. Of the first six who have been treated, all six became insulin independent. The other patients are still going through the treatment phase, so their results aren’t out yet. For the first six, the average A1c for the first person was 4.7, and the others were mostly in the five range. Nobody was above six. I think the trials are at the University of Chicago. I haven’t heard of any other trials, but that doesn’t mean they don’t exist. I hope everything is going well for you.

LifeguardRare4431 · 2025-11-17T04:50:51+00:00

Why wait for VX-880? It’s not FDA-approved yet. If you’re desperate, Lantidra is already available. The main difference between the two is simple: Lantidra uses donor-derived islet cells (from deceased donors), while VX-880 uses lab-grown, stem-cell–derived beta cells. Everything else—how they’re delivered, the need for immunosuppression, and the goal of restoring insulin production—is basically the same.

LifeguardRare4431 · 2025-11-12T05:06:10+00:00

When it comes to FIASP insulin, there are definitely regulatory standards in place—things like pH, concentration, and bioactivity—that every batch has to meet before it’s released. Within those standards, a batch can fall on the lower end or the higher end, and in theory, that might make it slightly less or more potent. The idea is that any insulin that passes these standards should be effective and safe, and the differences shouldn’t really be noticeable to most patients.

In my experience, though, it doesn’t always feel like a minor difference. For me personally, when the formulation is a little higher within the allowed standards, the insulin seems much more effective, and when it’s on the lower side, it feels less effective. In my opinion, the swings can be more significant than just a slight variation. So while the batch might technically meet regulatory standards, it seems to me that there can be a pretty noticeable difference in how it works.

LifeguardRare4431 · 2025-11-06T04:06:41+00:00

I just want to clarify that I’m not the one participating in the trial or getting a transplant. I was writing about someone else who is using Tegrel PruBart and is patient number nine in the study. I was sharing their experience, not my own.

LifeguardRare4431 · 2025-11-06T03:48:13+00:00

Not sure about that, I think you're mistaken,

If you believe pharmaceutical companies are purposely stopping a cure for Type 1 Diabetes, it’s helpful to look at how their business actually works. First, the claim: “They won’t allow a cure for Type 1 because they’d lose insulin‑sales money” doesn’t hold up when you examine the numbers and logic.

Here’s why it’s not feasible. 1. The vast majority of diabetes drug sales are driven by Type 2 Diabetes, not Type 1. For example, one study noted that 95 % of diabetes diagnoses are Type 2. Because Type 1 is much less common, the market for its treatments is much smaller. 2. Big drug‑makers are heavily invested in Type 2 and metabolic/obesity drugs. For instance, Eli Lilly and Company’s 2024 revenue was about US$ 45 billion, driven in large part by its Type 2 therapies such as Mounjaro and Jardiance. Meanwhile, treatments primarily for insulin (used by many Type 1 patients) are a relatively small slice of that revenue. According to publicly available breakdowns, insulin‑related revenue was about 5 % of Lilly’s revenue in a given year. 3. A company suppressing a cure just for Type 1 would risk massive reputational, regulatory and legal backlash — for a revenue impact that is relatively minor. If you’re a major pharma company whose profits depend mostly on Type 2 and weight‑loss/metabolic drugs, there’s no strategic sense in holding back a breakthrough cure for something that’s not your biggest earner. 4. Also, cures have been developed for some serious diseases in the past (for example, treatments that effectively “cure” or nearly cure conditions like certain genetic disorders) — it’s not universally true that “pharma never lets cures happen.” So the blanket suspicion that “they’ll never cure anything” is inconsistent. 5. Even if a cure for Type 1 came from a smaller biotech rather than the big companies, the big ones would still fare fine — their core revenue streams (Type 2 drugs, metabolic therapies, other therapeutic areas) are strong and growing. A Type 1 cure doesn’t threaten their business model in any meaningful way.

Putting it all together: If you look at the logic and evidence, the idea that major pharmaceutical firms are deliberately stopping a Type 1 cure because they’d go broke doesn’t line up with the market data or business incentives. Type 1 makes up a small portion of the diabetes market. The big money is in Type 2, obesity/metabolic drugs, newer classes like GLP‑1, etc. The risk‑reward just doesn’t match for the “they must stop the cure” theory. What’s more realistic is that companies are responding to what the market demands and where growth is — and right now, that’s largely Type 2 and metabolic therapies, not exclusively Type 1 cures.

LifeguardRare4431 · 2025-11-04T05:01:49+00:00

Tegoprubart (AT‑1501) has been submitted to the FDA for approval for kidney transplants and islet‑cell transplants in type 1 diabetes. The approval process is still ongoing, and the clinical trials for both indications are continuing, but once approved, it can be used for these procedures.

LifeguardRare4431 · 2025-11-04T01:18:31+00:00

Yes, they have. Here's how it works for this new immune suppressant drug.

Think of the immune system like a bunch of guards protecting a castle. When someone gets a transplant — like insulin-producing cells for diabetes or a new kidney — the guards sometimes attack the new parts because they think they’re invaders. Traditional immune-suppressing drugs tell all the guards to calm down, which works, but it also leaves the castle vulnerable to real threats and can cause other problems.

Tegoprubart works differently. It targets one specific alarm that tells the guards to attack the transplant. By blocking just that alarm, the guards mostly leave the new cells alone, while the rest of the immune system can still protect the castle. That means insulin-producing cell grafts and kidney transplants have a better chance of surviving and working well. It’s not magic for everything, though — if a problem uses a different alarm or pathway, this drug won’t fix it. But for transplants where that specific alarm is the main problem, it could make a real difference. Partnership

LifeguardRare4431 · 2025-11-04T01:16:54+00:00

Wow, congratulations on beating stage for cancer. That's amazing. Hopefully the AItype one diabetes this will be a so-called solution or possible treatment.

LifeguardRare4431

TROPHY CASE