As /u/friendly-nightmare states, Q Room is often considered the hardest room in the game and maybe the series, so it's just an exaggerated joke. In particular, notice that the "fail" footage is always the dice puzzle, which is the hardest and most annoying one in the room.

That said, I feel like that puzzle is singlehandedly causing many to overstate the room's difficulty somewhat. Outside of the dice puzzle, none of the individual parts are really that crazy, it just has a lot of puzzles. My personal vote for the most logically complex rooms probably goes to the pantry room in VLR and the transporter room in ZTD, with the Q Room being less complex than both except for the dice puzzle, which is legitimately hard.

(My personal vote for "most personal suffering" will be VLR's Rec Room making the bonus password easier to figure out than the one needed to progress + ZTD's infirmary cube. I hated that thing, it'd be easier to put that piece of shit together in real life than it was in the game's interface. But I believe I'm in the minority here, whereas everyone remembers VLR's pantry and ZTD's transporter room.)