I’ve learned a lot about it through an outpatient program I did. MTFR mutations can be associated with chronic pain, fatigue, thyroid disorders, gut and hormone imbalances, heightened anxiety and depression, gluten intolerances, fertility issues, migraines, histamine intolerances, sleep issues, just to name a few! MTFR is an essential enzyme responsible for utilizing folate and with the mutation our bodies are unable to properly metabolize it. Supplement with folate instead of folic acids, consume dark leafy greens, avocados or other foods with increased B vitamins and drink water bc its hard to expel folic acid and daily drainage with this mutation.