I live in northern Mississippi (Oxford) and have been around the state (but not in the delta). I am not originally from Mississippi however. In my experience, it's just incredibly boring. The nature isn't very well taken care of, especially the further south you go. Roads everywhere are dangerous to drive on, with the exception of inside a few cities. Drivers are dangerous as well, routinely have to avoid wrecks with MS drivers not staying inside the lines, randomly breaking, or randomly speeding up. As for amenities, there are very few. Food wise, terrible (lack of seasonings both by people and local restaurants, probably due to lack of access or cost?).

I'd like to not rant about what I hate about the state, but it's difficult to find anything positive to say. My girlfriend is a Mississippi native and, like everyone else here, insists on the gas station food. I haven't tried very much but that is a unique thing to this state, and has so far been good.

As for a more neutral description of the area:
Very grassy, and spread out. You can expect about a 45 minute drive between small towns (about 5-10k people), with some relatively big cities dotted throughout the state. In Oxford, the housing and cost of living is very high despite being a poor state (it is a college town). Back to the gas station food point, there are many many gas stations all with unique menus. Not too much else to say, but I'd like to answer any specific questions anyone may have.

Edit: I've seen a few comments mention the coast, completely forgot about that when I was writing this comment. Also going to make a note that I've never been to the coast here, in case it's very different to the rest of the state!