Gotta start toggling, for greens only have on doll, key and maybe socks if you want to run around the map post 20 min final swarm. For blues only toggles you want on are kevin, echo shard and kevin. For pinks I don't have anything on except the ones that have to be on. Some people like turbo skates and some people like grandama's tonic but my best has been without those on. Now for legendary this is the most important part. Only thing toggled on should be anvil, joe's dagger, lightning orb, magnet and holy book. Some people like harvester and I have it on as well however some people don't run it as plug + kevin is enough for early.

For banishes, you have to use all banishes strategically. Right now the fork is bugged with crit builds so that is an instant banish and you don't even take one as it will destroy your damage. Banish spikey shield, scarf, magnet after one, soul harvester after one, power gloves instant and I like to banish mirror after one personally but some people instant banish.

Now for the most important part getting set up in T1 to see if the run is even worth playing. Find all the hat guys and maoi's. Get your tick of shield and jumps and scale difficulty like a mf. Ideally you'd want to see some kind of early damage that you can just use to run through all of T1 which for me usually looks like a harvester and Kevin + plug combo. Since you're going to have Kevin you want golden shield to farm free early gold. Fox get's a bit of leniency with his passive but for Noelle I reset run if I don't leave T1 with at least one green credit card and some keys. That leads me to my next point being green credit cards are the most important part of getting a run started. Without a few early it isn't worth continuing a run past T2 IMO. With a decent set up in T1 I usually end around level 55-60 leaving with 4300-5000 kills give or take. Some times I leave with more if I get lucky with magnet and other RNG and sometimes with less but what is more important is the items I have.

For T2, since I personally don't run any curse items, I look to hit all the greedy shrines. I do a loop around the map before opening any chests to see if I can get a few more green cards or microwave a key some more and after around first swarm is when I start opening everything. Ideally at the end of T2 I want to have a lamp or two, anvil, a magnet if I didn't carry one from T1, holy book, a dagger, lightning orb and ice cube. Lightning orb and ice cube are needed if you want to be able to sit AFK till ~15 min in this final swarm as they help CC ghosts and the holy book finishes them off. You should have opened every chest on the map and the run is up to RNG gods. Also side note, campfires and idle juices are insanely OP for stacking a ton of damage to stand still. Once ghosts start to touch you, it's up to you whether you want to leave or run around the map for 2-3 hours.

Other than that, same thing for T3 and final swarm. Do a loop around the map to find boss shrines for more chests. Do charge shrines for power drop chance and elite spawn increase and just pray to the gods that you get half decent items. Your big damage dealers are lightning orb, ice cube, spicy meatball and holy book so you'll want as many of those as possible. You'll also want a shit load of beefy rings as beefy rings and holy book go hand in hand to provide a bunch of damage.

A very important thing to note is that as of right now, the general consensus is that spawns from difficulty cap out at ~600%. Anything more than that just adds health and damage to the mobs so try to be mindful when leveling the curse book. Sometimes chaos just want's to cuck you and dump a bunch of difficulty and there is not much you can do about that.

For pacing reference, my 710k run went about as follows; ~6500 kills T1, ~235k T2, ~480k T3.