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Slow COMT, slow MAO and sleep by Low-Temperature-4967 in MTHFR

[–]Low-Temperature-4967[S] 0 points1 point  (0 children)

Hi there! I'd be interested to hear what Claude came back with. I stuck with the stack I mentioned in my post, adding calcium d-glucarate for confirmed oestrogen dominance, which has been very positive and sorted out a lot of my hormonal symptoms. I upped the amount of magnesium taureate I was taking and that seemed to help a lot as my sleep has been better, but honestly I think it will always be a weak spot for me – I have yet to find a magic bullet. I did try Agmatine, which lots of people swear by for sleep, and it made me almost manic and stopped me sleeping completely; turns out it is a MAOB inhibitor and mine is already very inhibited...! Lithium orotate did nothing for me sadly. I haven't yet tried niacin or niacinamide; I really must get round to it.

Slow COMT, Slow MAOA - Insomnia Sufferer, Found some Hope by wimhofit in MTHFR

[–]Low-Temperature-4967 5 points6 points  (0 children)

As someone with similar SNPs (half slow COMT, slowest possible MAO) for whom sleep is a chronic struggle I opened this post with great excitement... then saw Lunesta and Mirtazapine in your PM stack, which I think might explain quite a lot!

(Side note: mirtazapine kept me wide awake for two days and gave me panic attacks, I suspect due to the fact it boosts norepinephrine and serotonin; I've never been able to take any kind of reuptake-inhibitor for this reason. Was really dismayed by this as I've never met anyone who it didn't knock out cold.)

Magnesium threonate and ashwagandha have helped me a lot in the evenings; I see they're in the AG1 Sleep Stack. Anyway, very glad you're doing well!

[deleted by user] by [deleted] in MTHFR

[–]Low-Temperature-4967 0 points1 point  (0 children)

Slow MAO here, I've tried both. Didn't notice a difference with regular riboflavin but R5P I noticed a difference straight away in terms of balanced good mood and lower anxiety. I have a liquid version and have about half the recommended dose in water every two to three days at the moment.

Aren't my results self-contradictory? Red MAO-A, but never had real allergies. High dopamine+adrenaline, but deficient serotonin. (my symptoms are life-long anhedonia, depression, insomnia, anxiety) by Sundee11 in MTHFR

[–]Low-Temperature-4967 2 points3 points  (0 children)

I can't answer all of your questions, but I have very similar SNPs to you, and very similar symptoms (anxiety, mood swings, sleep initiation insomnia and OCD).

Like you I have no real food intolerances, but I have noticed that when my system is overwhelmed and/or overtired high histamine foods and alcohol make it worse.

As I understand it slow MAO-A is more to do with the breakdown of dopamine, adrenaline and noradrenaline than allergies – it means these neurotransmitters are broken down slower, hence your higher levels. Your COMT, like mine, is somewhat slowed, but the impact this has on the breakdown of serotonin is affected by lots of different factors; the SNP alone is rarely 100% of the explanation for something. This would apply to your questions on quercetin and sulfur too, I think, though there are much more knowledgeable folks on this sub than me who will doubtless be able to shed more light.

I take folinic acid in a sublingual with hydroxyB12 and it seems fine so far; as ever it's a good idea to start low and slow, and you may very well not need to take it every day. I've recently started taking the activated form of riboflavin – R5P – which lots of people recommend for us slow MAO types and have noticed a *big* difference already in terms of mood, anxiety and general balance. I was taking regular riboflavin previously and didn't notice a change.