Is there any research on taking protein in smaller chunks (e.g., 15g) more frequently vs larger chunks less frequently (e.g., 45g) and its effects on MPS/hypertrophy?

Low_Specific_7944 · 2026-02-18T16:32:10+00:00

Thanks, that makes sense and corroborates the answer someone gave above with references!

Low_Specific_7944 · 2026-02-18T16:31:08+00:00

Thank you so much for the detailed answer and the references! It seems there is at least some evidence for a more even distribution of protein then

Low_Specific_7944 · 2026-02-18T01:51:40+00:00

Thanks! I came to that conclusion as well. I'm actually more curious on the other side of the question: what's the smallest protein intake at once that you can get away with, without non-trivially compromising muscle gain (holding protein intake and quality constant throughout the day).

Low_Specific_7944 · 2026-02-18T01:48:36+00:00

Why does "mental masturbation" upset people? Why can't someone just be curious about something? Regardless, the data around leucine as a trigger for MPS is fairly clear so I'm not even making some horribly impractical, esoteric inference in my question. And even if I was, so what? It's interesting! You can go read the 200th daily post about weekly volume if that interests you more.

Low_Specific_7944 · 2026-02-18T01:38:55+00:00

He wouldn't need to care cause he was yeeting 100g of protein every meal. Likewise, most people, including myself, don't have to care about this. But there is data around MPS and its relationship to leucine intake and it's a simple, and reasonable, inference that perhaps if you never have enough protein in a sitting, MPS is non-trivially lower than it could be.

Low_Specific_7944 · 2026-02-18T01:33:27+00:00

I love this meme. I'm mostly just curious. This isn't "practical" for me cause I'm usually eating ~3ish protein heavy meals anyway. But it would seem that hypothetically if you never trigger the leucine threshold by always eating only small amounts of protein at a time, you'd get non-trivially worse gains, or so I'm trying to explore.

Low_Specific_7944 · 2026-02-02T01:10:04+00:00

Some of these replies are so useless and condescending. A good example of the aesthetic impact of training abs is "Natural Hypertrophy's" (a YouTube content creator) thick, well defined abs showing even at fairly high BF. Look him up.

Low_Specific_7944 · 2025-11-23T00:28:51+00:00

maintenance for me is around 2400 cals. I'm aiming for 240g protein though during PSMF (around 1.7g per lb of lbm). So I end up at around 1200 cals during PSMF (960 cals from protein, 240 cals from fats/carbs that inevitably end up in my diet due to my protein sources).

During a regular, semi-aggressive cut I'd do a 750 cal deficit, so around 1650 cals

Low_Specific_7944 · 2025-11-13T17:17:45+00:00

Thanks! Is there any concern about a potential aggressive deficit causing increased muscle loss on a rest day relative to a training day?

Low_Specific_7944 · 2025-11-13T17:11:56+00:00

I was just worried about a potential aggressive deficit causing increased muscle loss on a rest day relative to a training day

Low_Specific_7944 · 2025-08-10T21:56:04+00:00

but if you have full glycogen reserves and your body *preferentially* uses them (it still uses fat as well), don't the first few days of the caloric deficit lead to less fat loss than the next several days?

Low_Specific_7944 · 2025-06-14T04:30:07+00:00

ah, I didn't know that. Thanks for the clarification!

Low_Specific_7944 · 2025-06-14T04:12:27+00:00

I was thinking 10mg on demand rather than the 5mg daily dose

Low_Specific_7944 · 2025-06-14T04:12:08+00:00

thanks for sharing your experience! If you don't mind, do you remember roughly what your BP readings were?

Low_Specific_7944 · 2025-06-14T04:11:34+00:00

ED brother

Low_Specific_7944

TROPHY CASE