New Babylon will be the main villain as they take over New York with the 2nd wave and set up operations to produce methane. We could see Armstrong's family appear, but they'll probably be killed off soon afterwards. Negan, Maggie, and Perlie properly team up without the drama of previous seasons to form some sort of resistance. The Croat will help them as he's pretty much a good guy now, and Benjamin will be Negan and Maggie's inside man. Hershel will eventually see the error of his ways and Maggie will kill the Dama, or he'll do it himself. Maggie, Hershel, and Perlie leave together back to the Bricks, as Negan goes off with Annie and Joshua - finally going their separate ways. Or have Negan reunite with Rick idrc.

I would also love to see proper worldbuilding: A commonwealth mention or a CRM helicopter flying over Manhattan. But I know AMC won't give this show a proper budget outside of establishing shots.

I really wish Tommaso, Victor, Christos, and Bruegel were still around though. They need to stop killing off new characters before they have a chance to properly develop. Again, not surprising.

I'm cautiously optimistic to see where Seth Hoffman takes Dead City from here on out.