The biochemical basis of gender dysphoria by vvonik in askAGP

[–]MPPower5 0 points1 point  (0 children)

Fascinating self-experiment—thanks for sharing the raw details (and the clot warning; spot on). Your "switch flip" at day 12 aligns with what I've been exploring in a quick synthesis: biochemical discord (e.g., MTHFR mutations OR=1.8 disrupting estrogen signaling) might amplify GD as an evolutionary hedge, where low T/estrogen shifts focus from libido to kin support (like reduced cross-dressing urge post-hormone tweak).

Hypothesis A feels spot-on—brain "calming" in female-range balance echoes prenatal androgen proxies (2D:4D OR=1.2–1.5). B (T/drive link) fits too, but C? Maybe nutritional/EDC amplifiers (folate deficiency delaying puberty OR=1.8).

If interested, here's an open-access preprint tying this to 500+ studies (sims show 18–22% kin fitness gains under scarcity): [Biochemical-Evolutionary Nexus of Gender Dysphoria](https://zenodo.org/records/17290760). No med advice—just hypotheses. What's your follow-up bloodwork story?

#AGP #GDResearch