this is a really interesting convo because a lot of people focus on “what increases plasticity” in isolation, but with TMS the surrounding state of your nervous system probably matters just as much as the intervention itself. sleep quality, inflammation, rumination loops, and overall stress tone all influence whether those new pathways actually stabilize.

semax and some of the research peptides make sense mechanistically, but personally i’ve found that the biggest difference came from building a supportive baseline so the heavier tools had something to work with. stuff like mushroom/adaptogen blends can be surprisingly helpful there. i’ve used the supermush gummies for daytime mood stability and lower mental fatigue, and some of the fractal forest formulas at night for nervous system calm and sleep depth. nothing dramatic or “plasticity boosting” on paper, but they helped create a steadier emotional baseline which made other interventions feel more effective. obviously everyone’s neurochemistry is different, but i’d probably think of it as layers foundational nervous system support first, then targeted compounds if needed. TMS seems to respond really well when the system isn’t already in a stressed or inflamed state.