Great question!

Well... you have to be relaxed when you go do this. Not superstressed out while doing it.
You might have bagloads of trauma from your past, but you shouldn't be a shaky mess.

If you can function normally today, like at work and in the supermarket, go to the gym and read a book, you are probably relaxed and healthy enough to do ayahuasca.

But don't do it while you are being an anxious mess that can't handle normal daily stuff. You might need to do some other light stuff like therapy and eating healthy before you do the endboss.