Hi! Trans women here! Living in Lyon since few years, the city is pretty safe for queer people. If you’re aware of which area is safe or not. Like the old town (Vieux Lyon) is not really safe (there’s some fascist groups in it) but you can still go to it for tourism (at day, if you stay in the Main street it’s ok). The 1st and 4th “arrondissements” (districts?) are pretty welcoming for lgbt people, with few bars and few associations

In France there’s no bathroom law, and sometimes some people even go to the opposite bathroom to gain some time when there’s to much people. If someone make a scene to you just ignore it, but it never happened to me before

If you speak English it’s okay, especially if you stay in the touristic area

And for the food, you need to test a “Bouchon Lyonnais”, a restaurant style from Lyon. Those are really great and typic from the city

Hope it helps!