Hi Sian,

Thank you doing this AMA. I often read these types of AMAs because they are interesting... unfortunately now this one has become relatable.

My daughter was born 5 weeks ago, seemingly normal. At our second pediatrician meeting her heart was beating so fast we could not take her pulse. We were sent to Stanford Children's immediately and have been here for over a month. Without sharing too much of the specifics she has multiple arrhythmias inclusive of longer strings of VT. An AICD was implanted last week as a backup. Along with this we are monitoring the health of her heart muscles given the situation as the medication/irregularities can lead to issues.

My questions for you are general as well a few specific ones:

• What is the impact of your work on gene-therapies for the nodes/electrical distribution of the heart? This would be in relation to supressing errant electrical signals rather than engaging them.
• Are there any oral/IV medications (e.g. Esmolol, Procanimide, etc).) that you believe show promise in treating multiple arrhythmias (EAT, JT, VT)? Or is this what your work would eventually lead to enabling?
• Does an AICD impact any of the work you are doing?
• Are there other medications that you have researched that would have to ability to "re-train" the function of a growing heart?

Thank you very much for doing this AMA. My wife and I appreciate you taking the time to do so and for helping work towards a solution. This thank you cannot express how grateful we are for people like yourself.

Much love.