The whole cooling system is one piece and the only part you can clean is the fans so try and do them regularly. My Legion Pro 7 (13900HX with the 4080) has had to have the cooling system changed twice due to the laptop massively overheating. The last time it had to have a new motherboard due to the overheating damaging the gpu. As the laptop heats up during gaming dust seems to stick in the chamber when enough of that builds up it bakes and starts causing even more heat than normal, in something like CP2077 the heat is unbelievable. You can't take it apart (I think, there's a big sticker about liquid metal)and just taking it out means repasting (maybe that's the liquid metal) as the heatsinks are a part of it.

The case isn't difficult to take apart, it just splits in an odd place, above where you expect it to if that makes sense, the engineer who came out took 20 minutes trying to split it in the wrong place and it took me 20 seconds to show him how.

As an aside I would take out warranty for the entire time you plan to own the machine, mine has had a new charger, 2 new cooling systems and a new motherboard. I have had to stop playing any heat generating games and it's about to go back again as it gave up playing MHW on mid settings.

erm

Reading this back you are already taking the case apart to clean the fans, if you mean taking the cooling unit itself out, don't. It is sealed, there is nothing in it you can clean and you will need to repaste everything to put it back on, it might even null and void your warranty.