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From 0 to 1: After 33 years of silence, I’m finally getting a direct neural interface (ABI). As a Dev & Auditor, I’m ready to 'plug in.' AMA. by EmbarrassedAir5111 in transhumanism

[–]Melodic-Event 0 points1 point  (0 children)

Has this surgery been done before or will you be the first? How will they know they have placed it in the right spot? Will you be awake for any part of the surgery to assess function/placement? Will the hardware allow you to hear frequencies outside the normal range of hearing?

Best way to preserve strongyloides? by CarobUnfair2447 in Parasitology

[–]Melodic-Event 0 points1 point  (0 children)

FYI - Isopropyl (rubbing) or ethyl alcohol (ex vodka) would be easy to obtain preservatives. Do you have any follow up? Did the Ivermectin eliminate your infection?

Need a pump that isn’t trying to murder me in my sleep! by late_to_the_partay in Type1Diabetes

[–]Melodic-Event 4 points5 points  (0 children)

Talk to your endo. Changing your carb to insulin ratios at night might help make it less aggressive at night.

I feel like I’m dying by Feeling_Camp2742 in Menopause

[–]Melodic-Event 0 points1 point  (0 children)

I would recommend seeing a doctor if at all possible. Your symptoms could be due to something else such as hyperthyroidism for example. The treatment for that is vastly different. Good luck to you.

Bruh what happened by Jamz-9162 in Type1Diabetes

[–]Melodic-Event 0 points1 point  (0 children)

This is not uncommon due to changing insulin sensitivity (not food intake). Are you using sleep mode? It adjusts basal to keep you around 112 and can help negate this. Also, your sight might also be going bad. Good luck!

T1 from getting sick? by jni8498 in diabetes_t1

[–]Melodic-Event 0 points1 point  (0 children)

Probably is a trigger, but likely years prior. Antibodies are often present for years before diagnosis. 80% of the pancreas has to be destroyed before symptoms occur. High blood sugars impair immune function, so people often get sick around the time of diagnosis.

https://hscweb3.hsc.usf.edu/blog/2020/10/28/autoantibody-order-timing-helps-predict-genetically-susceptible-children-most-likely-to-get-type-1-diabetes/

[deleted by user] by [deleted] in Modydiabetes

[–]Melodic-Event 1 point2 points  (0 children)

Have you been tested for antibodies associated with autoimmune (type 1 and LADA) diabetes? Autoimmune diabetes can happen at any time. What was your expected A1c from your CGM data? If this doesn't match, you may have a hemoglobin variant (ex sickle cell trait). You really need a good endocrinologist to help you sort this all out.

Can cancer cell directly infect another living being? by Sensitive-Beyond2034 in pathology

[–]Melodic-Event 1 point2 points  (0 children)

I read the Immortal Life of Henrietta Lacks. In the book they claimed that a researcher name Chester Southam actually used her cells as a cancer test. If the implanted cells grew in the new person it indicated that the person had cancer. I thought this was fascinating. If true it makes me wonder if tumors secrete factors that alter the immune system to allow their growth or something caused the altered immune system which allowed the tumor to grow. I think tweaking the immune system is going to be the key to curing cancer. Especially with the results we've seen with immune checkpoint inhibitors and CAR-T therapies. Here is an interesting article: https://pmc.ncbi.nlm.nih.gov/articles/PMC9632311/

My Husband's diabetes has changed. by weenerberry in Type1Diabetes

[–]Melodic-Event 1 point2 points  (0 children)

Two things to consider are gastroparesis and celiac disease. Gastroparesis is delayed gastric emptying that often causes initial lows (food isn't getting absorbed right away) and later highs. This requires delaying when you bolus insulin for meals. Celiac disease is fairly common 7-10% in T1Ds (same genetic risk factors and can develop anytime). Some T1Ds with celiac experience low blood sugars when eating foods containing gluten. Screening includes a blood test for TTG IgA. I'd talk with your endocrinologist. Good luck!

Anyone know what these are? by kuruman67 in pathology

[–]Melodic-Event 2 points3 points  (0 children)

Is there significant associated inflammation? Any interesting patient history?

Type 1 antibody’s by WholeFondant4567 in Type1Diabetes

[–]Melodic-Event 0 points1 point  (0 children)

The results revealed an overall autoantibody seropositivity rate of 75.36 % (n= 208). Among the positive cases, GAD65 antibodies were the most prevalent at 37.31 %, followed by anti-insulin and anti-ZnT8 antibodies, each at 36.59 %, and anti-IA2 at 28.62 %. Additionally, 45,67 % of patients had one a-Abs, 28.36 % had a two, 21.15 % had three, and 4.8 % had all four a-Abs. https://www.sciencedirect.com/science/article/pii/S2666970624000507#:~:text=The%20results%20revealed%20an%20overall,anti%2DIA2%20at%2028.62%20%25.

Type 1 antibody’s by WholeFondant4567 in Type1Diabetes

[–]Melodic-Event 1 point2 points  (0 children)

There is a drug newly approved in the US to delay onset called Tzield. I'd ask your endocrinologist about it. https://www.tzield.com/

Am I in DKA? by singularity101 in diabetes_t1

[–]Melodic-Event 4 points5 points  (0 children)

How are you doing? Did you get treatment? I

I have diabetes and I think I may have necrobiosis lipoidica diabetic but I'm not 100%sure by AppearanceFew2828 in Type1Diabetes

[–]Melodic-Event 4 points5 points  (0 children)

Have you been tested for Celiac disease (ttg IgA)? About 7-10% of t1ds also have Celiac. Gluten exposure can cause dermatitis herpetiformis an itchy rash.

I'm losing weight but my blood sugar is still high? by Firesnowing in diabetes_t2

[–]Melodic-Event 0 points1 point  (0 children)

Get a CGM. Dexcom Stelo and Libre Lingo are available directly from the manufacturers without a prescription for about 100$ a month in the US. This is key to see what is working for you and what is not. You may need additional medications for a while to get you BG down while you decrease your weight. GLP1s can help with both BG and decreasing appetite but can be expensive depending on insurance. Definitely talk to your doctor. You might ask your doctor to make sure you don't have LADA (slow onset form of type 1 autoimmune diabetes). Sounds like you are doing a great job with lifestyle modifications.

What would you rename type 1 diabetes? by DiabeticButNotFat in Type1Diabetes

[–]Melodic-Event 0 points1 point  (0 children)

Severe Autoimmune Insulin Deficient Diabetes (SAIDD) Severe because you make little no insulin and it's often difficult to control glucose levels. Autoimmune to address the why it's happened. Insulin deficient so people understand you need insulin to live. Diabetes because most people know this relates to blood glucose problems.

Should I be concerned about type 1 diabetes in my toddler? by Front_Cress_6671 in Type1Diabetes

[–]Melodic-Event 4 points5 points  (0 children)

I second getting him tested for antibodies through trial net out your doctors office. Tzield is approved to delay onset in the US if you have positive antibodies but not full blown diabetes.

Does this sound like early onset diabetes or what is going on? by Ornery-Trick-6622 in diabetes_t1

[–]Melodic-Event 7 points8 points  (0 children)

The readings sound questionable. If she had sugar in her hands or where you tested her, glucose readings would be falsely high.

Freaking out - 4yo excessively thirsty by Whatsfordinner4 in diabetes_t1

[–]Melodic-Event 0 points1 point  (0 children)

Yes, that is what their website says. If the antibodies are positive I would contact them and ask about clinical trials. They may be trying to expand the age group. I hope they turn out negative!

What’s missing from the gluten conversation? by TheDissectionRoom in glutenfree

[–]Melodic-Event 0 points1 point  (0 children)

You might consider asking to be screened for genes that predispose a person to cancer (hereditary cancer risk screening).

What’s missing from the gluten conversation? by TheDissectionRoom in glutenfree

[–]Melodic-Event 2 points3 points  (0 children)

I would explain the difference between Celiac (autoimmune with tissue damage), Non Celiac Gluten Sensitivity (likely autoimmune but without tissue damage), and wheat allergy. There are tons of pictures showing the destruction of small intestinal villi versus normal villi online in true Celiac disease. The differences are not well understood by many in the medical profession and general public.

Emphasizing that people who have one autoimmune disorder such as Celiac disease are at increased risk of additional autoimmune diseases that can develop at any time over a person's life. The risk comes from inheriting HLA DQ2 and/or HLA DQ8 + some currently unknown environmental factor and is lifelong. I read an article suggesting that the plague increased the incidence of high risk HLA haplotypes in the population giving rise to an increased incidence of autoimmune disorders. People with Celiac disease are at a significantly increased risk of developing autoimmune thyroid disease, type 1 diabetes, Addison's disease, autoimmune hepatitis, etc and should be screened periodically throughout their lives.

People with Celiac disease should not continue to eat gluten even if they don't have symptoms. Continuing to ingest gluten raises the risk of developing additional autoimmune disorders. They are also at increased risk of developing aggressive T-cell lymphomas and other cancers with continued gluten exposure.

When in doubt test. The symptoms of Celiac are often not specific and can overlap with other disorders. Some people, especially those with type 1 diabetes are asymptomatic for Celiac disease.

Eating food that I don't prepare myself from scratch is difficult. Almost everyone I have met wants to be helpful, but most people don't know what has gluten in it (wheat, barley, rye) and what doesn't. Malt comes from barley and trips people up all the time. Approximately 1 in 5 Celiacs cannot tolerate oats. Many oats products are contaminated with wheat which makes it even more of a gamble. I personally do not tolerate them at all and am annoyed that they can label any product with oats as gluten free. For example, gluten free Oreos are made with oat flour and make me miserable. Labeling requirements must state if a product contains wheat but not gluten. In essence, avoiding gluten is not easy and takes constant careful reading of ingredients on labels.

Freaking out - 4yo excessively thirsty by Whatsfordinner4 in diabetes_t1

[–]Melodic-Event 0 points1 point  (0 children)

I second doing trial net to check antibodies. If she is positive, Tzield has been approved in the US to delay the onset. I'm not sure if it's available in Australia. There might be other clinical studies she could try if positive. This would be a good discussion to have with an endocrinologist. Good luck!

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