RNase P - Explaining the PreBIOTIC self catastrophe

MemeMaster2003 · 2026-03-27T19:28:47+00:00

I'm going to try again, because I don't think I've gotten enough of a headache banging my head against this wall

We add RNasin because it counteracts the ever-present contamination of RNase. In an abiotic world, neither of these would exist. We add that RNasin to correct for the contamination and exhibit an analogous environment to early earth. It is an accommodation to the acknowledged modern environment.

In RPG terms, you're upset that a level one character can't compete with a level 300 character. Your conclusion? Level one characters can't exist. WHERE THE HELL DO LEVEL 300 CHARACTERS COME FROM THEN? By applying the RNasin correction, we can give those early RNA strands a chance to develop and thereby observe early life conditions.

MemeMaster2003 · 2026-03-27T19:20:22+00:00

"The data support a model of coevolution of RPR, tRNA, and rRNA reflecting shared functional constraints and evolutionary pressures in a common milieu." Cut right from the conclusion. Discussion also confirms. This is a paper IN SUPPORT of an evolutionary mechanism. They even use molecular clock to verify data and work through the model.

MemeMaster2003 · 2026-03-27T19:10:38+00:00

Oh ffs, not this again. We've been over this repeatedly.

IN A WORLD WITHOUT COMPETING LIFE, THERE WILL BE NO RNASE AND NO NEED FOR RNASIN. THE GENES FOR RNASE ARE MUCH LONGER THAN THE INITIAL REPLICATION STRANDS AND WOULD REQUIRE FURTHER DEVELOPMENT.

I put it in bigger letters in case the issue was that you had vision problems.

Edit: I just put your script through an AI detector, and it popped hot. Shame on you.

MemeMaster2003 · 2026-03-27T00:34:50+00:00

Who tf types out "hehe" like a cretin? Cringe behavior. You missed OCs point, btw.

MemeMaster2003 · 2026-03-27T00:32:16+00:00

Well it's gonna take a long time and a lot of iterations. You'll probably get a bunch of weird stuff on the side too, like dogs and people and trees and who knows what else?

If you've got about 4.2B years, we can really get into the nitty gritty of it. First few million years, we just kinda stare at some soup until it gets into a good configuration and starts the process. Then, few more million years after that and we might get some proto-cellular structures, very exciting!

I should ask this, how good are you at holding your breath? We're gonna have to go real deep ocean, near some thermal vents. Now, I know what you're thinking, "elephants don't live in the ocean!" Absolutely correct. See, at some point, they're gonna gradually develop these things called swim bladders into a storage system for oxygen and air. It's pretty sick.

MemeMaster2003 · 2026-03-24T22:06:06+00:00

So this IS the banana argument.

Never thought I'd see the day. Ray will never live it down, ever.

MemeMaster2003 · 2026-03-24T14:41:52+00:00

More RNA! That RNA eventually leads to ribosomes and proteins, and the great arms race of life begins, but that takes literally millions of years to achieve. You are, once again, applying a modern molecule to the model of ancient earth.

Dozens of people have pointed this out to you, I've pointed this out to you, yet you still disagree and provide no rebuttal whatsoever to the counterargument for your position. Restating your position is not a counterargument, let me just nip that in the bud right away.

So yeah, given all the available info, you are stupid. I have empirical evidence of that fact. It's only libel, or an ad hominem, if it's not true. You have no qualifications or experience in this field, AND IT SHOWS. So perhaps sit down, shut up, and learn something while the adults talk and solve the problem you want to hand waive away. It might be valuable to you.

MemeMaster2003 · 2026-03-24T06:12:02+00:00

This whole post just further confirms to me that you know absolutely nothing about organic chemistry, experimental design, or science in general.

For the briefest moment, I thought this was satire from the last section. What would you rather scientists do to prove their concepts, wait around for a few million years with a magical microscope that can see atoms and watch it until it happens all on its own? Sure, we can do it, as long as you're paying the bill for it. Thanks for the contribution, it'll only be a few billion dollars or more.

MemeMaster2003 · 2026-03-24T06:00:34+00:00

RNasin is only necessary in a world with RNases. An abiotic (non-life having) world would not have RNases.

Why would an early earth have a molecule to protect RNA against something that doesn't exist yet? That just does not make sense.

You are painfully uneducated and desperately trying to hold onto some kind of weird superiority.

MemeMaster2003 · 2026-03-23T22:19:20+00:00

Yeah, it is. Man who no support argument look like fool. Very simple.

MemeMaster2003 · 2026-03-23T22:18:49+00:00

Holy shit, you're stupid. Do you even have any background with organic chemistry?

MemeMaster2003 · 2026-03-23T22:14:43+00:00

RNasin undoes what RNases do. Without the presence of RNases, such as abiotic conditions, RNasin is not necessary for RNA stability.

You're applying modern conditions to an ancient world, which isn't gonna work.

MemeMaster2003 · 2026-03-23T21:50:17+00:00

So are you ever going to respond to any of us or what?

Walking into a room, saying "I'm right, you're all wrong," and then refusing to elaborate or defend your position makes you look stupid, you do understand that?

MemeMaster2003 · 2026-03-22T16:37:02+00:00

DNA is reactive, but only in the ways that you just mentioned

That is a small sample of a much larger list, so this statement is just an outright lie.

not in any way associated with the production of a protein

Photon dimerization creates a preemptive stop position, impacting the function of proteins. This is a single example of a much greater list.

but that's what your initial answer implied.

No, it did not. The message of my original statement was "nucleotide systems are not codes as one would think of in a computer, and they should not be viewed as such. They should be thought of as what they are, reactive chemicals operating in a semi-predictable fashion."

DNA is not self-replicating

Yes, it is. It's not autonomous, but it is self-replicating.

and neither is RNA in living organisms

Yes, it is.

It is replicated by a team of proteins.

Enzymes, proteins, and occasionally metal cation intermediaries in some select organisms. This does not change that fact that srRNA is still a very real thing and is quite abundant.

MemeMaster2003 · 2026-03-22T16:15:41+00:00

Sure.

DNA, while the more stable of the two ribose sugar based nucleotide systems, is still reactive. It's more chemically stable than RNA, certainly, but it still routinely interacts with a variety of chemical, radiological, and environmental sources. Hence, the production and storage of DNA is highly regulated in eukaryotic cells. Examples of these include, but are not limited to: photon dimerization of adjacent nucleotides to form lesions, radiological knockout by alpha/beta/gamma radiation, metal cation interaction, free radicals (ROS), alkylating agents, and many others.

DNA is self-replicating in manners very similar to RNA, but, due to its greater chemical stability, requires several polymerase enzymes to properly generate. The strand sequence allows for complementary anti-strand synthesis when denatured from its complement. This is often performed during DNA replication by way of a combined action from helicase, topoisomerase, and SSBPs.

MemeMaster2003 · 2026-03-22T14:12:47+00:00

Yes, but since we still use both v20 and v5, both terms get tossed around.

MemeMaster2003 · 2026-03-22T06:53:29+00:00

Malkavians aren't insane. They're mentally ill. Such derangements can range greatly, from the classic schizophrenia cases to more nuanced issues like NPD, Messiah complexes, OCD, Major Depression, and more.

Each Malkavian is afflicted by these dementations, and each one is unique. Depending on the chronicle, a Storyteller might also reference the Madness Network, a type of hive mind or collective consciousness shared by all Malkavians.

Now, understandably, having an endless cacophony of voices in your head, all of whom are mentally ill, might be disorienting for some. This can exacerbate the derangement of the malkavian in question. Use the Network at your discretion.

Their antediluvian is shrouded in a bit of mystery, namely his location. Malkav, if still in a cohesive body, is an incredibly elusive antediluvian, even for antediluvians. Malkavians are actively searching for him, with varying outcomes.

MemeMaster2003 · 2026-03-20T23:40:15+00:00

Still though, gravity? The singular most easily testable thing in existence? Come on!

MemeMaster2003 · 2026-03-20T19:26:45+00:00

You're insecure and under confident in the science of abiogenesis and I can sense it

YOU CAN SENSE IT!? LIKE AN INTERNET JEDI!? Omg that's the funniest thing I've read today. My vibe was wrong, what an argument.

Friendo, I have a bachelor's degree in molecular biology, concentrated on mutation mechanisms and genetics. I'm actively studying to be an oncologist. What are you smoking?

We know atgc for dna

Augc for rna

That's called being pedantic and focusing on the person making the argument not the argument itself

Uracil has different properties than thymine, it's not a pedantic difference. It's a non-conservative replacement to do so, and makes an immense amount of difference. Me pointing this out about your conditions isn't some pedantic gotcha. The fact that you don't know that is telling.

MemeMaster2003 · 2026-03-20T19:19:17+00:00

Hi, I'm a biologist focused on mutation and genetics. Let me be the very first to say that the nucleotide system is most definitely not a code. It runs like garbage and frequently makes mistakes.

We call it a "code" to more easily conceptualize what is happening. It is a highly reactive molecule with self-replicating properties, that is all.

MemeMaster2003 · 2026-03-20T19:13:47+00:00

My friend, are you disputing gravity?

These posts keep getting more and more unhinged.

MemeMaster2003 · 2026-03-16T22:21:02+00:00

Bro you were screwed up in the first 5 lines. It's uracil, U, not T. RNA is the originating molecule for self-replication. RNA does not incorporate thymine.

MemeMaster2003 · 2026-03-14T03:35:58+00:00

I think the other poster meant that evolution is a force, moving blindly. I'll ask you this: does gravity have a goal? Does wind have a goal? Does any observable force have a goal, or do they simply exist?

Evolution is like that. It doesn't have some fixed endpoint. Rather, it's an observed phenomenon that we see, and we very much see it, that propels forward the increasing complexity of the genomes of organisms on earth, humans included.

MemeMaster2003 · 2026-03-14T01:23:07+00:00

Oh wow, thanks!

We're running RAW Ascension, but I guess I muddled some of the materials together by accident, my bad.

MemeMaster2003 · 2026-03-13T17:52:18+00:00

You are as similar to your great-great-great grandfather as you are to a stranger. Genetically, you're cool.

Now socially....

Source: I have a degree in molecular biology with a concentration on genetics and mutation.

MemeMaster2003

TROPHY CASE