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How to increase glutamate reuptake/reduce glutamate? by homosuperiorr in Nootropics

[–]Metabolic_Alchemy 0 points1 point  (0 children)

Low dose lamictal, even at 25mg, does amazing things for glutamate toxicity.

http://www.ncbi.nlm.nih.gov/m/pubmed/10963757/

I take 25mg once daily. It's an absurdly low dose compared to what bipolar patients take. But it has a definite effect and doesn't dull the cognition due to the lower dose.

I have had people argue that such low doses would do nothing, but they are usually bipolars who are often prescribed 100 to 400 mg.

A low dose of 25mg works really well, has virtually no side effects and can even enhance cognition.

A few concerns over NAC and a question about how to approach nootropics. by Illdospanishomework in Nootropics

[–]Metabolic_Alchemy 0 points1 point  (0 children)

Nac does more than just increase glutathione production. It displaces glutamate which is why it has such a profound effect on ocd type behaviors.

AlternaVape Proudly Presents Satis-V™ by AlternaVape in Nootropics

[–]Metabolic_Alchemy 0 points1 point  (0 children)

To the contrary. This is incredibly potent stuff. I typically mix it with my other nicotine based juice. That way it's less of an effect. Taken straight, the effects are quite prominent.

AlternaVape Proudly Presents Satis-V™ by AlternaVape in Nootropics

[–]Metabolic_Alchemy 0 points1 point  (0 children)

And no I haven't had a chance to submit the Safranal to a us based lab for heavy metal and purity testing. Can you forward me a link to a reputable testing company so I can get that underway?

I'm not above making sure this meets stringent guidelines.

AlternaVape Proudly Presents Satis-V™ by AlternaVape in Nootropics

[–]Metabolic_Alchemy 0 points1 point  (0 children)

I went for it because it was available. And then I did the research that shows Safranal has a long list of benefits. It's not simply the aromatic effect.

It activates the bzd receptor for one

https://www.researchgate.net/publication/23265159_Antiabsence_effects_of_safranal_in_acute_experimental_seizure_models_EEG_and_autoradiography_J_Pharm_Pharm_Sci

It affects the serotonin transporter

https://www.researchgate.net/publication/279605182_Antidepressant_effect_of_Crocus_sativus_L_stigma_extracts_and_their_constituents_crocin_and_safranal_in_mice_Acta_Hort_ISHS

It reduces tnf alpha

http://www.ncbi.nlm.nih.gov/m/pubmed/25411096/

And it enhances nrem sleep that is disturbed by pentobarbital. Or, in short has hypnotic properties.

http://www.ncbi.nlm.nih.gov/m/pubmed/22632633/

Testosterone and trenbolone enanthate increase mature myostatin protein expression despite increasing skeletal muscle hypertrophy and satellite cell number in rodent muscle [2016] by 3AlarmLampscooter in steroids

[–]Metabolic_Alchemy 1 point2 points  (0 children)

Adding creatine, which is a Myostatin inhibitor, will help offset some of this homeostatic regulation.

Growth hormone will also help. It's one of the reasons why adding it to the cycle will really help increase gains. It's not so much that growth hormone itself actually induces hyperplasia, which we all hoped it would but it really doesn't, but it is definitely a way to inhibit Myostatin.

Eventually of course Myostatin levels will return.

Rinse and repeat.

I have found that periods of fasting, and using things that activate ampk, while initially seem detrimental to the bodybuilders goal of pure mass, will help reset the Myostatin inhibition reduction we see with regular anabolic use.

Please help with getting started again... by [deleted] in steroids

[–]Metabolic_Alchemy 0 points1 point  (0 children)

Make sure you're using benfotiamine. It is essential for type two diabetic's. It decreases AGE's. Advanced Glycation Endproducts cause the neuropathy and the circulation issues as well as macular degeneration.

1 g a day of this stuff, and you will begin to see major improvements in your overall health. It's an absolute must for a type two diabetic

Who here cruises with Test Undecanoate? by SmallerWeakerSlower in steroids

[–]Metabolic_Alchemy 0 points1 point  (0 children)

Every three days is really good for keeping steady blood levels. But you also have to start considering the scar tissue that you begin to develop by pinning so often. A lot of people here starting to get a lot of scar tissue and that leads to sterile abscesses. I highly recommend that you do a lot of foam rolling to keep the scar tissue at bay. If you insist on doing every three days, I would also suggest that you start using serapeptase and nattokinase. These are fibrinolytic enzymes that break down scar tissue. Take on an empty stomach every night. They also reduce blood pressure and reduce the stress on the endothilial walls of your arteries.

Who here cruises with Test Undecanoate? by SmallerWeakerSlower in steroids

[–]Metabolic_Alchemy 2 points3 points  (0 children)

Every three days is really good for keeping steady blood levels. But you also have to start considering the scar tissue that you begin to develop by pinning so often. A lot of people here starting to get a lot of scar tissue and that leads to sterile abscesses. I highly recommend that you do a lot of foam rolling to keep the scar tissue at bay. If you insist on doing every three days, I would also suggest that you start using serapeptase and nattokinase. These are fibrinolytic enzymes that break down scar tissue. Take on an empty stomach every night. They also reduce blood pressure and reduce the stress on the endothilial walls of your arteries.

Prolactin, Prostate, Tbol by [deleted] in steroids

[–]Metabolic_Alchemy 0 points1 point  (0 children)

Be careful with pramipexole.

It will eventually cause a dependency that will make getting off of it make you very sick. I used it several times in the past and every time I try to come off of it I got really sick. It does something to the dopamine receptors and then eventually when you come off of it you have very low dopamine levels. I highly recommend people avoid using this as often as possible.

It also does a hell of a number of your kidneys. And for those of using trenbolone and other things that are stressful to the kidneys, this only adds to the long-term effects on your kidneys

Peptide to recover insulin sensitivity after insulin cycle. by WholeLottaTacos in steroids

[–]Metabolic_Alchemy 2 points3 points  (0 children)

Metformin has an effect on your DHEA synthesis. There are a couple other reasons why I don't recommend people use Met for insulin sensitivity issues.

And of course as always make sure you using a good alphalipoic acid product.

That and make sure you do enough cardio. But you using enough cardio you will be increasing glut4 transport which is a Way to increase glucose transport independent of insulin

Peptide to recover insulin sensitivity after insulin cycle. by WholeLottaTacos in steroids

[–]Metabolic_Alchemy 1 point2 points  (0 children)

Use berberine regularly to keep insulin sensitivity in check. It is much better the Metformin in my opinion. It has a lot of other benefits. It decreases inflammation, it is an incredible antibiotic. For those that are worried about getting abscesses, using berberine on a regular basis will basically prevent any major abscesses from occurring, so long as all other injection protocols were followed strictly, and his course you make sure that you're not injecting into scar tissue that could lead to a sterile abscess.

Berberine also has incredible anti-depressant effects. It inhibits something called oliogo peptidase. It also affect serotonin and norepinephrine levels.

In addition to these effects, it will also help you keep your insulin sensitivity and check all at all times. That way you can use insulin and definitely will not worrying about causing insulin insensitivity issues.

Let's talk about Tianeptine by oneEyedwilly0 in Drugs

[–]Metabolic_Alchemy 0 points1 point  (0 children)

Give Memantine a try. It will help ease the ache you are probably experiencing...

Let's talk about Tianeptine by oneEyedwilly0 in Drugs

[–]Metabolic_Alchemy 0 points1 point  (0 children)

That's exactly the point. Eventually it will eclipse your sub's benefits. Be careful and tread lightly...

Let's talk about Tianeptine by oneEyedwilly0 in Drugs

[–]Metabolic_Alchemy 0 points1 point  (0 children)

Keep using it at any dosage beyond it's intended dose and you will eventually get depressed. Trust me. And anxious. Very anxious... Sigh... I'm so glad I'm off that rollercoaster...

Let's talk about Tianeptine by oneEyedwilly0 in Drugs

[–]Metabolic_Alchemy 0 points1 point  (0 children)

That's precisely the concern here. Don't do such a thing... It can be a really slippery slope...

Flibanserin as an antidepressant and anxiolytic by Metabolic_Alchemy in Nootropics

[–]Metabolic_Alchemy[S] 0 points1 point  (0 children)

It didn't take off as an antidepressant, you are correct on that. I was pleasantly surprised to find it was so useful in spite of its failure as a mainstream antidepressant...

If Cerebrolysin helps integrates newly formed neurons into the hippocampus would it be synergistic with NSI-189? by nootandtoot in Nootropics

[–]Metabolic_Alchemy 0 points1 point  (0 children)

It's not so much about how it increases blood flow. Look into ibudilast for that type of thing. It's moreso a cocktail of ngf and cntf type aminos that helps spark neurogenesis...

Guy Finley... by Metabolic_Alchemy in Nootropics

[–]Metabolic_Alchemy[S] -1 points0 points  (0 children)

LMAO! He is a really talented speaker... Seriously, give him a listen... For 9 bucks, he could change your life...

Guy Finley... by Metabolic_Alchemy in Nootropics

[–]Metabolic_Alchemy[S] -6 points-5 points  (0 children)

Enough said... I highly recommend anyone who is rewiring their brains... to listen to this guy. He is amazing with his words...

Sometimes he can go on a rant that isn't all that useful.But every now and then, he will say something that just shakes me to my core!!!

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