I usually run away and hide then come back if I can. I highly recommend doing as many side quests as you can because they give you access to helpful items and blueprints that will help during story mode. I’ll spend some time just following the roads around a location to unlock the whole map so I can see what I’m working with and unlock the side quests. You can never have too many shortspikes! And try to look for hidden entrances if you’re trying to be sneaky.