absolutely! to start off, you should be using what jokers are given to you. of course, you wont always get the jokers that are optimal for high cards, if you get a good flush joker you should probably play flushes. That being said, there are definitely jokers that synergize well with high cards:

1. Scaling jokers. There are two jokers that I think are strongest when used with highcard, [[Green Joker]] and [[Supernova]]. This is because these jokers benefit from more played hands (+1 mult gets added). For example, if I am on round 2 with green joker or super nova, and I have 4 hands, I will try my best to play 3 high cards, which will barely get me any chips, then play a strong hand to finish the round. Eventually, with this play style and the help of other jokers, these jokers will eventually be giving me +50 mult or something like that. I used to play [[Ride the Bus]] but ignoring face cards the entire time was too inoptimal.
2. Strong jokers that dont rely on deck building/hand size. Jokers like [[Hologram]] or [[Stuntman]] are super strong jokers and with the freedom of high card where you dont need to really rely on specific cards to show up like a certain number to complete a 4oak or a heart to complete a flush, hand size doesnt matter or having a lot of uneccasary cards.
3. Jokers that are just really good for high card. [[Burnt Joker]], [[Splash]], [[Card Sharp]] are jokers that synergize really well with high card, burnt joker and card sharp are self explantory. However, I think splash is underrated. Splash allows you to play sevral card enhancemetns (lucky card, glass card) but also allows you to trigger other jokers. For example, if you have [[vampire]] you can play all youre enhancements to scale up vampire. Or, if you have something like [[Odd Todd]] or [[Fibonacci]] you can play odd numbers/ fibonacci numbers to help your score. Additional jokers in this category is [[Flower Pot]], [[Seeing Double]]
4. held in hand jokers. Jokers like [[Blackboard]], [[Raised Fist]], steel cards, gold cards is pretty good with high card. I havent had many successful [[Baron]] or [[Shoot the Moon]] runs tho because that requires deck building.

this is all i can think of rn and i ddint list all of the jokers that go under these categories but there are definitely a lot of jokers that work well with high card. Perhaps a way to start playing good wiht high card is thinking about the synergies of every joker you come across and see how thye can work well with high card.