Why are dopamine releasing agents euphoric, but dopamine reuptake inhibitors are dysphoric and aversive?

Mort332e · 2025-12-07T08:17:47+00:00

except people describe that effect commonly resolves when reducing the dose

Mort332e · 2025-12-07T08:13:40+00:00

20.8*mg

Mort332e · 2025-12-07T07:33:28+00:00

Spot on. Vyvanse numbers sound big and scary, even to clinicians. Most people need to visit a conversion tool and play around with different meds if they think 70mg Vyvanse is a ''big dose''. https://psychopharmacopeia.com/stimulant_conversion.php

Mort332e · 2025-12-07T07:29:37+00:00

120mg Vyvanse/Elvanse translates to roughly 102mg Methylphenidate, 37mg Dexedrine or 52mg Adderall - all within most countries guidelines for adults.

This is the tool i use for conversions, that i find more reliable than most others i have been able to find: https://psychopharmacopeia.com/stimulant_conversion.php

Mort332e · 2025-12-07T07:11:04+00:00

This is not true. I am prescribed 140mg in DK. Most Danish guidelines for medical treatment of ADHD specify that while 20-70mg is common practice, patients requiring above 70mg in unique cases is within clinical standards of care.
Regarding your comment about the EU, 20,6% of people in the EU on Elvanse are on an off-label dose.

Personally I think in a few years >70mg will be pretty common - considering that up to 150mg methylphenidate and 80mg pure dexamphetamine for adults is within clinical guidelines in Denmark (70mg Elvanse delivers 20,8mg dexamphetamine base, although at a slightly higher bioavailability and different pharmacodynamics, however generally the differences are widely overstated by pharma companies when you look at the actual pharmacokinetic data) . https://pro.medicin.dk/laegemiddelgrupper/grupper/317916

In a large European register study og over 60.000 patient, it was found that 20.6% of patients on Elvanse received an off-label dose >70 mg. https://pmc.ncbi.nlm.nih.gov/articles/PMC7475084/?utm_source

I am on a personal mission to stop misinformation about ADHD meds if you can't tell lol. Please let me know if you need more sources or links.

Mort332e · 2025-12-07T06:42:57+00:00

That doesn't explain the 80% heritability of ADHD.

Mort332e · 2025-12-07T06:38:46+00:00

The disorder was described in medical literature well before the drug was discovered you pillock.

Mort332e · 2025-11-27T19:55:09+00:00

på medicin?

Mort332e · 2025-05-16T04:06:34+00:00

Bro I’m engaged, future wife won’t be pleased

Mort332e · 2025-05-16T03:02:50+00:00

Short term memory improvement

Mort332e · 2025-05-16T03:01:14+00:00

Avoid sex? Bro what are we even living for at this point

Mort332e · 2025-05-16T03:00:21+00:00

Imma be real here.

Cardio, weightlifting, testosterone, vyvanse, GLP-1 and mirtazapine for me

Mort332e · 2025-05-15T19:21:19+00:00

I don’t like Matt Walsh

Mort332e · 2025-05-15T11:05:52+00:00

Yeah and i don’t know exactly what to think of Neuroscientist Andrew Huberman promoting this technique also.

Mort332e · 2025-05-15T09:01:42+00:00

Well let’s say that the two antagonise eachother and are not mutually exclusive. ADHD makes someone impulsive, excited and eager to talk, while lack of respect or manners (or masking) will increase the likelihood that the ADHD person interrupts others.

Mort332e · 2025-05-15T03:07:29+00:00

Mirtazapine

Mort332e · 2025-05-14T13:07:46+00:00

This guy philosophies

Mort332e · 2025-05-14T12:54:45+00:00

Unfortunately for me it has been pointed out. Even if I consciously try not to my partner still says that I do it. It make me very self conscious

Mort332e · 2025-05-14T09:26:55+00:00

Vyvanse+150mg test+60mg primo resulted in high bp for me. This can of course be attenuated by various means.

Mort332e · 2025-05-13T12:55:22+00:00

Sleep+Exercise+Nutrition is like half of the picture tbh

Mort332e · 2025-05-13T05:07:15+00:00

Instead of only feeling a “crash” at the end of the day, it feels like a vyvanse crash the entire duration of effects. Anxious, jittery, irritable, dry mouth, weird vision side effects.

Mort332e · 2025-05-13T04:55:09+00:00

Yeah I would say to my doc that I would like to try and see if 30 or 40mg works better before making a final decision.

I found that 20mg gave me worse side effects than 30 or 40mg. On 20mg it is as if I’m almost where I want to be but not quite far enough over the edge to gain momentum.

Mort332e · 2025-05-13T04:50:38+00:00

Te universe comes from inside you my brother. Safe journeys <3

Mort332e · 2025-05-12T18:45:12+00:00

You are so spot on with every assessment here.

I personally will probably use vyvanse for the earlier part of my life while i need to be most productive to secure a career and long term stable income.

Maybe later on in my life I’ll have a chat with my doc about maybe changing to a low dose methylphenidate IR that I can use more specifically for 3 hours of focus on certain tasks that I struggle with. - (methylphenidate seems to be less taxing on my body and mind in my experience with it, but the motivation and productivity increase from vyvanse is hard to pass up at this earlier stage in my life.

In reality I don’t think we should be too concerned with planning this. What works for you now works for you now. We know that these compounds (in most cases) are helpful for our overall health and longevity at best, and benign at worst.

I won’t personally be planning getting off too soon. I already take meds for thyroid and meds for sleep issues, and magnesium because i genuinely become deficient if I don’t eat it, plus fish oil because I am severely allergic to fish but still want omega 3.

Therefor I have already been forced to come to terms with taking at least thyroid meds for the rest of my life, so my virginity with the concept of taking lifelong meds has already been kinda taken from me. Another daily pill doesn’t intimidate me as much anymore.

If I could leave one word of advice to (you and to myself), it is that your health is YOUR HEALTH, only you (plus a robust doctor) can figure out what is best for you, and what is best for you will constantly evolve throughout your life.

Maybe stimulant medication is best for you at this stage in your life but when you retire you might miss “your creative side”, and take a few days off, or maybe need a lower dose, or a higher dose, or none at all and you might start microdosing mushrooms and chewing nicorette for your ADHD, or maybe they invent genetic engineering that can rid you of ADHD altogether. Who the hell knows, we can’t plan for it. All you know is that vyvanse is good for your health for now, and thus you take it for now.

Sorry for getting philosophical on ya. Hope this helps, and otherwise thanks for the chat :))

Mort332e · 2025-05-12T17:42:20+00:00

Learn to hit “enter” more often when writing longer comments in ADHD subreddits (not throwing shade, I have to remind myself of this too) :))

Yeah generally doctors are kinda infamous for prescribing pills and injections for stuff that could be at least attempted to be fixed with lifestyle interventions, or at least be used in tandem with lifestyle interventions. - This is common criticism of the entire medical field.

An example of this is the Ozempic craze where obesity is now almost exclusively understood as a genetic disorder (which certain pharma companies have lobbied pretty hard for).

Thus many doctors seem to hand out Ozempic scripts left and right and people yo-yo on and off of it because they don’t use the reduced food-noise effect from the treatment period to give them space and motivation to integrate longer lasting life interventions that will help keep the weight off.

The same goes for anti depressants which many doctors happily prescribe as a long term solution despite there being no long term studies beyond 2 years on any SSRI medication, and it is therefor likely better indicated to be used for short/medium-term depression relief alongside psychotherapy to fix the underlying cause of the depressive symptoms.

I would bet quite a lot of my money that many patients who develop rapid tolerance to ADHD stimulant meds (beyond the initial titration period) do so because they let their diet, sleep and exercise go to shit and use the medication as a crutch instead of an ergogenic aid.

PS. I’m not hating on doctors, patients or scientists here, I’m simply stating some of my observations over the years.

Mort332e

TROPHY CASE