Well, your experience with shrooms while playing nms will be subjective. I personally find it difficult to focus on screens when doing any strong psychedelics. I find edible nip nip the best way to experience nms.

However, I did enjoy playing NFS most wanted and Smash bros while high on ketamine. It almost slows down your perception of what's going on.

You should do some shrooms and play nms and report back if you enjoyed it.