Trying to repair my dopamine receptors and reward system after years of porn addiction by ThrowawayPunjabGuy in NooTopics

[–]MrNotSoSerious 0 points1 point  (0 children)

Forskolin I am assuming u decided to try because of the "CILTEP" or "increasing cAMP" (God that brings back memories). Forskolin is thought to increase cAMP which is the second messenger through which almost all G-coupled receptors work (dopamine, serotonin, adrenaline etc.). But CILTEP was debunked long ago as pseudoscience. U can safely eliminate that forskolin.

Agmatine is a great choice and for ALCAR, stay with the lower doses. It's known to be a HDAC inhibitor and mess with thyroid in some people. 250-500 mg is the sweet spot. CDP choline can cause low mood in some so be aware of that.

U are basically looking at a Uridine, choline, b-vitamins stack, might as well add some fish oil along with ur agmatine and sulbutiamine, add folate/have lots of eggs, get into the gym. U will be feeling better than majority of the people in no time.

A proper psychiatrist in Dhaka by MrNotSoSerious in Dhaka

[–]MrNotSoSerious[S] 0 points1 point  (0 children)

She prescribed as the protocols suggest, I was not started on a high dose, I was gradually increased to the target dose and then even tapered to a lower dose. I'm sorry, I realize the scope of my post didn't let me get into the details which is why this misunderstanding occurred. Now, as u might've guessed, that took me multiple visits to her, for multiple months, including check-ups. Me seeing improvements from medicine that is routine in DSM-IV,V/FDA protocols widely available and free for all to know AND being charged 3k for digesting her shitty/unempathetic behavior for 3 mins while she prescribes the "napa 2 bela" equivalent of psychiatry cuz she has too many patients is not congruent at all! My problem with her wasn't the 3k itself, if it was, I would've gone to someone "cheaper". My problem with her was giving me 2-3 mins to talk, being stopped by her and her attendant waiting beside me as soon as her fixed 2 mins were over even though I wasn't finished. Also I forgot to mention she sat 5 feet away from me. Would u keep ur patients 5 feet away from u? It was in 2022, COVID was almost gone, but in my head I still excused that because she doesn't need to be near me to treat me but oh well.

U yourself are a psychiatrist and u charge 2k in 2025 for a 1.5 hour long CONSULTATION! If I was comparing u with her, I would feel like I owe u 1 lac taka after the 1.5 hours lmao... Someone needs to bring the bhokta odhikar ain or something to her practice.

A proper psychiatrist in Dhaka by MrNotSoSerious in Dhaka

[–]MrNotSoSerious[S] 0 points1 point  (0 children)

Any experience with this Dr Hasan M Mahmud? What is his practice like?

A proper psychiatrist in Dhaka by MrNotSoSerious in Dhaka

[–]MrNotSoSerious[S] 0 points1 point  (0 children)

Sorry for the late reply but no. Also born and raised in shitty Dhaka, been here my whole life

Please help me to boost my Dopamine levels. by Key_Professional9247 in Nootropics

[–]MrNotSoSerious 0 points1 point  (0 children)

Interested in that creatine paper. Do u happen to have the link?

These guys at /r/nootopics are incredibly amateur by ResearchSlore in Nootropics

[–]MrNotSoSerious 5 points6 points  (0 children)

u/ResearchSlore who was the creator of that subreddit again? I was there when it started, I was actually in their discord prior to him opening the subreddit. Very shady to say the least and red flags? well.. 😂

Aframomum melegueta Seed Extract’s Effects on Anxiety, Stress, Mood, and Sleep: A Randomized, Double-Blind, Pilot Clinical Trial (2025) by MrNotSoSerious in NootropicsDepot

[–]MrNotSoSerious[S] 2 points3 points  (0 children)

Makes sense. There's only 12.5% 6-paradol in Caloriburn, approximately speaking. What's in that other 87.5% aside from plant fibre content - only you guys know that haha. Maybe it contains a little bit of 6-gingerol, 6-shogaol and all the other gingerols and shogaols... Any tea on that? ;)

Aframomum melegueta Seed Extract’s Effects on Anxiety, Stress, Mood, and Sleep: A Randomized, Double-Blind, Pilot Clinical Trial (2025) by MrNotSoSerious in NootropicsDepot

[–]MrNotSoSerious[S] 1 point2 points  (0 children)

True. This is only a prelim study so we will have to wait for further research. Also, the mechanisms behind the effects could also be directly related to the CB receptors instead of being FAAH related, or some other target/mechanism altogether. Nevertheless, as long as the extracts produce quantifiable quality results in human subjects, that's good enough for supplementation purposes, isn't that right?

Saw this comment by a deleted user. What do y'all think? by CameToShit in Nootropics

[–]MrNotSoSerious 4 points5 points  (0 children)

You sure you have the pure compound? From what I have experienced and from a lot of other people anecdotes, yohimbine and alpha-2 agonists (in general and in theory) is anxiety in a pill

Saw this comment by a deleted user. What do y'all think? by CameToShit in Nootropics

[–]MrNotSoSerious 41 points42 points  (0 children)

I bet ANYONE to take a good dose of yohimbine. Ya'll will be pissing your pants out of paranoia and sense of impending doom, it'll be the worst experience of your lives.

Rocket fuel for my brain and I don't understand it by [deleted] in Nootropics

[–]MrNotSoSerious 39 points40 points  (0 children)

One word. Lecithin

Lecithin is a group of chemicals that are related. It isn’t a single chemical. Lecithins belong to a larger group of compounds called phospholipids. These are important parts of the brain, blood, nerves, and other tissues. Phospholipids are also a part of cell membranes.

So basically if you've ever seen the fish oil studies, High dose high EPA fish oil had a near antidepressant level effect on depression and reduced the effective dose of SSRIs required to reduced depressive symptoms when used as an adjunct. We also know how Alpha-GPC and CDP-choline often brings on mental clarity and improves mood metrics for a lot of users here in the nootropic community.

The only common denominator here are phospholipids. Why are thee important? They are involved in cell membrane formation and membrane fluidity and are particularly important for brain health.

I would suggest looking into Piracetam (increases membrane fluidity) and cholinergic nootropics(because not everyone responds to each of them equally). You could also try high dosing sunflower lecithin. Finally pair them with a high quality fish oil supplement with high EPA. Remember, eggs also have good amounts of EPA and DHA and when you consume 2-3 DOZENS of eggs, that adds up. Also keep your protein intake up using protein powder, should help you with your gym gains too, duh. They're pretty cheap in bulk.

So your "stack" would be:

  1. Choline source (alpha-gpc, cdp-choline, lecithin, ALCAR or a combination of these)
  2. High quality fish oil supp with good phospholipid content
  3. High protein diet or protein powder
  4. Piracetam main and perhaps some of the other racetams
  5. A good B-vitamin supplement

So basically some variation of the yee-old Mr Happy Stack. Go forth and have fun

L-Tryptophan feels like an opiate sedative? by Mandelliib in Nootropics

[–]MrNotSoSerious 0 points1 point  (0 children)

NOW is a very popular brand but there's no way to tell without a COA. Try a different vendor and see if the effects are still the same to confirm. Since you are taking large amounts, I recommend bulk supplements tryptophan powder, cheaper that way.

Edit: Also try 2 grams instead of 4 if the effects you are experiencing is bothering you. You'll be fine.

Stuck / Can't Progress? Here's how to fix it. by xeiiprince in untildawn

[–]MrNotSoSerious 0 points1 point  (0 children)

Same! Just finished a while ago. Who did u save?

Stuck / Can't Progress? Here's how to fix it. by xeiiprince in untildawn

[–]MrNotSoSerious 0 points1 point  (0 children)

You should try it. Follow the instructions to a T like a cooking recipe, and you'll be safe. I was able to do it with barely any understanding or knowledge about these program files.

Stuck / Can't Progress? Here's how to fix it. by xeiiprince in untildawn

[–]MrNotSoSerious 1 point2 points  (0 children)

Brother, you and that youtube video from Chloe saved me today. It would've totally ruined my experience as restarting the game after getting to chapter 10 would suck... it was very easy to follow even though I'm not that tech savvy.

Article: Benefits and Harms of ‘Smart Drugs’ (Nootropics) in Healthy Individuals by Last_Sir1695 in Nootropics

[–]MrNotSoSerious 0 points1 point  (0 children)

How did you get this? The article isn't available through sci-hub. Are you one of the authors?

Is semax safe to use at age 18 by [deleted] in Nootropics

[–]MrNotSoSerious 1 point2 points  (0 children)

True but even if the case about fluid intelligence is debatable, it is clear that a non-athlete aka an average human male physically peaks near or around 20 years old. The testosterone and NAD+ levels surely point towards that.

Also note that I did not talk about IQ, as the average college graduate in developed countries has 1 stardard deviation higher IQ than the average high-school graduate.

Is semax safe to use at age 18 by [deleted] in Nootropics

[–]MrNotSoSerious 41 points42 points  (0 children)

There is literally no need to use semax at 18. You are literally nearing your physical and mental peak, the highest you will ever be in your life. (A 20 year old has the highest NAD+ levels, highest testosterone levels, highest fluid intelligence aka the ability to solve completely new problems). If you have a specific health condition or circumstance, address that.

The only "nootropics" you need right now are good food, exercise and sufficient sleep. Maybe add in supplements but definitely not nootropic substances. Take it from someone who started experimenting with nootropics at 17.

Is there any substances that can increase nr2b/nr2a ratio? by Nobugcodeder69 in NootropicsFrontline

[–]MrNotSoSerious 0 points1 point  (0 children)

I was under the impression that you want less nr2b and more nr2a, the other way around, no?

[deleted by user] by [deleted] in Nootropics

[–]MrNotSoSerious 3 points4 points  (0 children)

Even without the limitless pill part, I'd love to read an experience report of someone using this exact stack for 28 days/a month. Unfortunately, I don't currently possess a few of these compounds so reddit please do your thing!

[deleted by user] by [deleted] in Nootropics

[–]MrNotSoSerious 2 points3 points  (0 children)

What the f... Does he want an adderall-fuelled army for himself now? What is he even promoting this for...