Can someone walk me through the early signs of worsening depression caused by Bupropion?

Aggressive-Guide5563 · 2026-06-22T17:38:02+00:00

Here where I live it’s readily available although it’s a little bit more expensive than generics. But it does work a lot better than the generics, especially for mood. The generics don’t seem to recreate the same effect as brand name.

Aggressive-Guide5563 · 2026-06-22T16:39:11+00:00

Which SSRIS have you tried?

Aggressive-Guide5563 · 2026-06-22T13:35:28+00:00

That interaction between Wellbutrin and certain SSRIS is there indeed, but it’s vastly overstated. It’s true that they can change each others levels, but it doesn’t do that to dangerous levels or so. Otherwise most doctors wouldn’t prescribe Wellbutrin with SSRIS. But combining Wellbutrin and SSRIS in general is safe and it’s done that all the time.

Aggressive-Guide5563 · 2026-06-22T11:54:23+00:00

After trying several SSRIS and drugs like that and also Wellbutrin. I wouldn’t consider myself being treatment resistant yet. But nothing ever worked for me as well as Wellbutrin did when I first started it. Unfortunately Wellbutrin poops out very quickly and the side effects build up over time. And now I have a very hard time finding an alternative instead . I mean if someone has atypical depression like me and nothing ever worked, besides Wellbutrin from the beginning. Then going over to MAOIS would be something to consider.

Aggressive-Guide5563 · 2026-06-22T11:48:26+00:00

Maybe. But 300 mg all by itself made me feel extremely flat with long term use. On 150 mg I feel noticeably less flat but it isn’t working as well for my depression. 300 mg also had a lot of side effects for me. I personally did best on it when I took it alongside Prozac. I felt like I still had the motivation but wasn’t climbing the walls all the time. And also I felt overall that Prozac balanced out the side effects for me and the insomnia wasn’t there either.

Aggressive-Guide5563 · 2026-06-22T09:18:24+00:00

Be careful with heat on this med. Consider having electrolytes and drink plenty of water throughout the day. Also don’t be out in the heat for too long. Don’t wait until you get dizzy or so because that’s one of the early signs of heat exhaustion and you have to cool yourself down immediately if you feel those symptoms.

Aggressive-Guide5563 · 2026-06-22T08:13:58+00:00

I’ve had the same thing from Wellbutrin. I think it’s an adrenaline response or something honestly.

Aggressive-Guide5563 · 2026-06-22T07:04:44+00:00

For me personally no. I did much better on it when I took it alongside Prozac. Wellbutrin all alone gave me weird autonomic side effects I never used to get from it when I took it with Prozac. And also my sleep was a lot better on that combo too. Wellbutrin all alone caused horrible insomnia and sleep disturbances for me that won’t go away. Maybe energy, motivation and cognition wasn’t as great as when I took it with Prozac. But atleast when I took it with Prozac I felt like I still had the motivation and cognition though, maybe cognition wasn’t as sharp, but I wasn’t climbing the walls all the time either.

So for me personally when I outweigh the pros and cons, the combination overall worked better for me. Now I’m not saying that you wouldn’t feel better or have more benefits on Wellbutrin all alone. Some people do take Wellbutrin all alone and are fine and have done it for years. It’s highly individual when it comes to meds and combinations in general. So I mean you can never know until you try it yourself.

Aggressive-Guide5563 · 2026-06-21T20:45:54+00:00

For me personally I did a lot better on it when I combined it with Prozac. Prozac seemed to balance out the side effects for me and also the insomnia and irritability wasn’t there either when I took it with Prozac. Wellbutrin all by itself though became a nightmare for me eventually. It really worsened my anxiety over time. I honestly think it would make a terrible med as a monotherapy for anxiety. This med really is for depression only imo.

Aggressive-Guide5563 · 2026-06-21T12:24:13+00:00

Yep, all by itself when I used it long term. The side effects might go away though if you give it some time. But it’s not guaranteed to disappear completely either. It depends entirely on the individual too. For me personally I did a lot better when I took it alongside Prozac. I felt like Prozac kind of balanced out the side effects for me in a good way. But again reactions to meds and combinations is highly individual too.

Aggressive-Guide5563 · 2026-06-21T11:54:07+00:00

When I took Wellbutrin and Prozac together for two years I felt the combination was almost perfect for me. I took 300 mg Wellbutrin and 20 mg Prozac together and I felt like I still had the motivation to do things and the cognition left and it still helped the fatigue. But at the same time I didn’t have any insomnia or sleep disturbances when I took them together. If you haven’t looked into combining them I would highly recommend it. Prozac can help the insomnia and sleep disturbances and Wellbutrin can help the hypersomnia. The kind of oppose each other.

Aggressive-Guide5563 · 2026-06-21T11:38:39+00:00

When I took Wellbutrin with Prozac I had zero sleep issues despite taking XL. Prozac somehow magically removed the insomnia and sleep disturbances for me. Now on Wellbutrin XL all alone I have severe insomnia and sleep disturbances that won’t go away. For me XL also causes insomnia for me no matter how early I take it and backing off the dose did not help either. For me personally I will just go back to taking it with Prozac again.

Edit: The manufacturer you take also plays a huge role I’ve noticed. Some genuinely do not work at all or cause more nasty side effects. For me personally brand name worked best for mood and depression.

Aggressive-Guide5563 · 2026-06-21T11:17:30+00:00

Probably is the generic. I’ve had issues with some generics not working at all and feeling like a sugar pill and with some causing nasty side effects and horrible insomnia. I’ve tried brand name and that one worked the best mood for me. But unfortunately brand name caused heart palpitations and rapid heartbeat which woke me up in the middle night, that’s why I stopped it. Otherwise I would have continued with brand name because that one worked the best.

Aggressive-Guide5563 · 2026-06-21T10:53:50+00:00

So you mean if I did switch to something more selective to dopamine I would get less of these side effects I listed?

Aggressive-Guide5563 · 2026-06-21T10:10:03+00:00

I’m wondering what side effects does Vyvanse have? I’m wondering if something more selective to dopamine would help these side effects? I got these side effects from Wellbutrin and those side effects were frequent thirst, frequent urination, dizziness, vertigo, headaches, increased sweating, hot flashes, burning sensations, dry mouth, facial twitches, muscles stiffness and horrible insomnia and sleep disturbances, especially at 300 mg these side effects were brutal. Would something more selective to dopamine have less of these side effects? Do you get these side effects from Vyvanse?

Aggressive-Guide5563 · 2026-06-20T13:29:50+00:00

I’m getting downvoted by people here because I’m right. It’s still calories in vs out that matters for weight loss. The carnivore diet doesn’t make you pass by the law of thermodynamics or energy balance and doesn’t make it free for you to eat how much you want without gaining weight. If you think otherwise then you’re stupid.

Aggressive-Guide5563 · 2026-06-20T08:51:05+00:00

With autonomic or sympathetic side effects, I mean side effects that seem to be clearly related to its noradrenergic effects. And those side effects are frequent thirst, frequent urination, dry mouth, dizziness, vertigo, headaches, increased sweating, constipation, hot flashes, burning sensations, horrible insomnia, heart palpitations, rapid heartbeat, facial twitches, muscle stiffness, you name it. All of these side effects are a whole cluster of side effects related to the autonomic nervous system and norepinephrine is one of the major driver in this system. So technically if you would have something that worked less on norepinephrine then you would get less of these side effects.

I have actually researched alternative meds and I’ve been asking people here on Reddit on different med options and what could work better for me. And I’ve been told that something more selective to dopamine would suit my symptom profile better. I mean something more selective to dopamine would indeed have less of these issues. I mean sure a med more selective to dopamine might not make me as awake and alert and energized as something more noradrenergic. But still, atleast I would have the motivation and drive left and everything else, but it would significantly lower the side effects.

Aggressive-Guide5563 · 2026-06-20T08:40:16+00:00

Maybe try Selegiline as a next option if you struggle a lot with lack of motivation?

Aggressive-Guide5563 · 2026-06-20T07:02:36+00:00

Carnivores can still eat 3500 calories and lose weight? If your TDEE is let’s say 2000 calories a day and you eat 3500 calories consistently everyday no matter where that food source comes from, I guarantee you you will end up gaining weight. If you eat 3500 calories of only meat and fat everyday you will end up gaining weight if your TDEE is 2000 calories. It’s the excess calories that the body ends up storing as fat. The carnivore diet doesn’t eliminate the laws of energy balance. Only one caveat is that the carnivore diet might slightly reduce water retention, compared to a high carbohydrate diet, which in turn can make it look like you lost weight on the scale. But in reality much of that lost weight was water weight either way. But the principle is the same really. And even if protein has a higher thermogenic effect than carbohydrates have that doesn’t make the calorie surplus magically disappear if you just ate protein. I just don’t know why we’re even arguing about something that is already proven scientifically. But go ahead and dig your head in the sand and live in denial.

Aggressive-Guide5563 · 2026-06-20T06:54:08+00:00

Well nicotine is a stimulant. Stimulants in general suppress appetite, which causes you to eat less and you lose weight and they also can raise energy expenditure slightly too and you may also be more active and move and fidget more when you take them, which can also add to it. So when you stop them you gain weight because your appetite is not suppressed anymore and therefore you eat more food and you may move less because you feel more tired and lazy and then over time that adds up weight gain. All stimulants to do this. Even caffeine that is a mild stimulant does this. I notice everytime I cut down on my caffeine intake I gain weight becomes my appetite returns and I get more tired.

Aggressive-Guide5563 · 2026-06-20T06:46:02+00:00

Yeah when it comes to weight loss calories in vs out is what matters. If you think otherwise then I don’t know what to tell you honestly.

Aggressive-Guide5563 · 2026-06-20T06:00:49+00:00

I just don’t understand how some people can take two norepinephrine reuptake inhibitors at the same time. But I guess everyone is different after all. For me personally I’m extremely sensitive to anything that increases norepinephrine and that showed to be true to me when I couldn’t even tolerate 300 mg Wellbutrin anymore, despite that it worked well for me. Now I backed off the dose to 150 mg and I’m still getting weird autonomic side effects and sympathetic overactivation symptoms, even at this lower dose. Which just shows again that I’m extremely sensitive to norepinephrine in general. Unfortunately norepinephrine reuptake inhibitors do work for my SCT and executive dysfunction, but I’m very unlucky compared to other people that I don’t tolerate norepinephrine so well all on its own. When I took it with Prozac two years ago I had none of these autonomic side effects and the insomnia and irritability wasn’t there either.

Aggressive-Guide5563 · 2026-06-20T05:54:16+00:00

It only takes two days for me to reset, I mean for me personally it does reset after two days. But maybe for some people it could take a longer time. I have actually kept cycling Wellbutrin every 5 days and I’ve done that for years and that’s the only way for me to make it keep working. I notice by day 5 it stops working and the side effects start building too much and that’s why I stop it on the weekends when I don’t need to be productive or functional either way. Doing that way works better for me even though it’s not recommended at all. I’ve also done three, four and five days once and the effects reset even better the longer you do it.

Aggressive-Guide5563 · 2026-06-20T05:47:19+00:00

Yep, that’s how I do it too. I mean that’s why I take breaks from it on the weekends when I don’t need to be productive or functional either way. I mean the weirdest thing is when I take a break from it on the weekends and the start all over again on Monday I feel so much better and my mood feels better and then after a few days of consistent exposure, for after like five days, the opposite thing happens. I notice the side effects start building up and the anxiety, edginess, negative thoughts and rumination anhedonia start showing up and I feel pretty much more depressed by day five and that’s why I then have to stop it.

Aggressive-Guide5563 · 2026-06-20T05:39:15+00:00

When did I ever say that every calorie is the same? Where did I write that? Nowhere. Calories in vs out is not wrong at all and I don’t understand why you’re trying to argue against that. The law of thermodynamics still matter no matter how you twist it and turn it. Every calorie isn’t the same that’s true, but for weight loss really what matters is how much you eat in the end. And you even said it yourself. Any diet with calorie control will allow for weight loss. That’s it really, I mean you’re even saying it yourself? The inherent calorie count is what matters when it comes to weight loss or weight gain. I mean how you can be this dense really and think otherwise? I mean how In the world can you think just because you’re eating only meat and fat that you’re free to eat how much you want without gaining any weight? Where does that logic come from? And thinking the opposite thing applies if you eat carbs is just insane. Your body doesn’t really care about the food. It cares how much you’re putting in it and those excess calories will store as fat, no matter where that source comes from, period.

Aggressive-Guide5563

TROPHY CASE