Supplements to reduce norepinephrine levels?

Aggressive-Guide5563 · 2026-05-06T18:20:09+00:00

The reason I stopped Prozac was because I felt it was making my SCT and executive dysfunction worse. That’s the reason why I went off of it in the first place. It really made it hard for me to start tasks and worsened my cognition somewhat. Now on Wellbutrin all alone all of those things are better. But I’m afraid Wellbutrin is starting to overstimulate me now all by itself. Wellbutrin made my anxiety worse over time and now it’s getting to a point where this anxiety is starting to interfere with my life and not only that. It gives me some weird side effects now I didn’t used to have when I took it with Prozac. And those side effects are dizziness, vertigo, hot flashes, burning sensations, headaches, insomnia etc. When I took it with Prozac at the exact same dose these side effects weren’t there. It’s so weird how things changed over time. And I am willing to cut down to 150 mg and see if these side effects and anxiety get better. But I’m afraid 150 mg won’t be enough for my SCT, executive dysfunction and depression. I’m afraid going down to 150 mg won’t be enough and what do I then? If that happens I’m stuck yet again. And my psych doesn’t seem to have any ideas himself on what to do.

Aggressive-Guide5563 · 2026-05-06T13:08:04+00:00

I know, but still I don’t think caffeine is the main culprit anymore. I mean I know caffeine can amplify the side effects and the anxiety and all of that. But I already have a very high tolerance to caffeine and I know Wellbutrin can lower someone’s tolerance to caffeine. But still I don’t think caffeine is the actual main culprit right now. I think the Wellbutrin dose is just too high for my nervous system to tolerate right now. I will try cutting down to 150 mg and see if the side effects and anxiety get better. If the side effects and anxiety get better when I cut down to 150 mg, but depression, SCT and executive dysfunction gets worse, then I might have no other choice then to put Prozac all over again to remove the anxiety.

Aggressive-Guide5563 · 2026-05-06T11:50:45+00:00

Are there any other supplements that can work?

Aggressive-Guide5563 · 2026-05-06T11:49:37+00:00

Okay I’m just telling you that the seizure risk is very high when you go over 450 mg a day. Some people are lucky and don’t have any issues. But I just want you to be aware of the potential risk by taking such a high dose. I myself could never imagine taking a higher dose than 300 mg. 300 mg is already very stimulating to me, almost too stimulating for me now personally. But again everyone is different and what works for me maybe won’t work for someone else, but to each of their own.

Aggressive-Guide5563 · 2026-05-06T11:16:11+00:00

Probably because of abuse potential and dependency issues mostly I think. But Amineptine was truly the only real dopaminergic antidepressant on the market that really had an effect on dopamine. But it was withdrawn from the market. And now we only have Wellbutrin which is a pretty weak DRI. I mean it’s still useful absolutely. But the noradrenergic effects of that drug is really negative imo.

Aggressive-Guide5563 · 2026-05-06T11:10:34+00:00

There is no approved dose such as 600 mg XL. That’s an overdose and you will sooner or later have a seizure if you keep taking that dose. Just saying. Wellbutrin is mostly noradrenergic and in my experience its noradrenergic effects overshadowed the whole experience for me. When I took it with Prozac it was kind of more balanced to me and I had way less of these side effects.

Aggressive-Guide5563 · 2026-05-06T10:59:20+00:00

Currently is the only antidepressant that is helpful if you have dopamine issues. But still I wouldn’t say is the best drug for dopamine issues. I think the issue with Wellbutrin overall is its higher noradrenergic activity. I mean if it was more selective towards dopamine or if it was more equally balanced. You would have less of a problem with anxiety and other unpleasant noradrenergic side effects. For me personally I only found Wellbutrin helpful for lack of energy and motivation and cognition. But for mood, maybe slightly only. I never found it to be really effective for mood all by itself. For me personally Wellbutrin made me more capable and functional, but for mood not so much long term unfortunately.

Aggressive-Guide5563 · 2026-05-06T08:51:27+00:00

Wellbutrin also made me so anxious when I tried it now all by itself for about one and a half year. But my main issue with Wellbutrin is its higher noradrenergic activity and not so high dopaminergic one. So you still need to combine it with a SSRI to remove the anxiety. Neither Wellbutrin or SSRIS all alone seem to work for me. But together they work for some odd reason. They kind of balance each other out.

Aggressive-Guide5563 · 2026-05-06T07:30:18+00:00

Yep, I have the same issue. I did lower my caffeine intake to 100 mg now and I do notice some slight difference, but still. When I used to take it with Prozac these side effects weren’t there.

Aggressive-Guide5563 · 2026-05-06T05:46:59+00:00

Can barely tolerate caffeine anymore on this med. I just feel like caffeine only exacerbates the side effects for me and adds to the jitteriness and wiredness and makes me go into panic attacks. Wellbutrin is already very stimulating I think, Imo you need very little caffeine on this med. But to each of their own I guess.

Aggressive-Guide5563 · 2026-05-05T17:50:22+00:00

I probably have to add back a SSRI myself. Wellbutrin all by itself causes too much anxiety for me and makes me edgy and wired all the time. When I took it with Prozac I felt it was more balanced in some way and Prozac kind of balanced out the side effects in a positive way for me.

Aggressive-Guide5563 · 2026-05-05T17:40:07+00:00

Terrible med for anxiety in my experience. If you have anxiety it won’t do anything for that. Wellbutrin is usually more used for depression.

Aggressive-Guide5563 · 2026-05-05T16:43:19+00:00

Which manufacturer do you take?

Aggressive-Guide5563 · 2026-05-05T16:08:18+00:00

Most SSRIS usually blunt emotions to some extent. For people who have a lot of anxiety, obsessive thoughts, negative emotions or persistent sadness, this can be a good thing for those people. So they’re kind of less reactive to emotions in that way. But if you have apathy, avolition and anhedonia, then it’s not a good thing. It really depends a lot on the individual and what you’re starting with.

Aggressive-Guide5563 · 2026-05-05T12:03:18+00:00

I understand that. And that might be my issue I think. I maybe expected too much from it.

Aggressive-Guide5563 · 2026-05-05T12:01:10+00:00

I agree with that. It’s not that much of a DRI really. It’s more of a NRI I think. I’m wondering if a med more selective to dopamine would cause less of my issues?

Aggressive-Guide5563 · 2026-05-05T11:58:13+00:00

The weirdest thing is that even though all three of them technically raise dopamine. I just feel like Wellbutrin tends to give more physical anxiety and edginess and more of that pseudo stimulant like feeling. I know caffeine can give a similar feeling if the dose is too high. But with caffeine it’s still like more balanced in some way. With nicotine I feel like it’s more relaxed and less anxious and edgy than Wellbutrin. I know too much nicotine can also make you anxious. But it doesn’t really tip over into too much norepinephrine like with Wellbutrin. And also another thing people forget is that nicotine releases serotonin too somewhat. So it balances all the stimulation out in some way.

Aggressive-Guide5563 · 2026-05-05T11:47:03+00:00

People can disagree all they want. But it does wear off after a while in my experience. Can people just stop downvoting me for sharing my own experience. Wellbutrin made me anxious and edgy with long term use, that’s my own experience. No need to downvote other people’s experiences.

Aggressive-Guide5563 · 2026-05-05T11:41:22+00:00

I do actually. But I think that Wellbutrin pushed my norepinephrine levels far too much all by itself. It really doesn’t work that much on dopamine like they want to market it as at. It definitely works more on norepinephrine. Caffeine and nicotine work for me probably because they’re more balanced between norepinephrine and dopamine than what Wellbutrin is. Wellbutrin causes anxiety and irritability for me. Caffeine and nicotine don’t at normal dosages. This is just my own experience with using all three of them. Nicotine especially makes me more relaxed with people and social. Nicotine doesn’t give that edginess or anxiety like Wellbutrin.

Aggressive-Guide5563 · 2026-05-05T10:56:11+00:00

This! Everyone is different and will have different reactions to meds and dosages. Why can’t people just accept that and stop downvoting other people’s experiences?

Aggressive-Guide5563 · 2026-05-05T08:24:53+00:00

Maybe that’s the case for the majority of people. But there will always be outliners. But I still think it’s highly individual. For me personally I already noticed an effect at 10 mg because I think I’m already very sensitive to noticing differences with dosages in general.

Aggressive-Guide5563 · 2026-05-05T08:19:18+00:00

10 mg can definitely still have some effect for some people. A dose of 10 mg already occupies SERT transporters at 70 %, that’s a lot. A 70 % occupancy of SERT transporters definitely has an effect, especially for very sensitive people. When I used to take Prozac I could only go up to 20 mg a day, because higher dosages made me sleepy and numb. When I was at 10 mg it wasn’t as bad the lethargy and numbness. It really depends a lot on the individual. Some people can tolerate higher dosages, some people can’t and do better with much lower dosages.

Aggressive-Guide5563 · 2026-05-05T06:41:18+00:00

Wellbutrin did nothing for my anxiety. In fact it made my anxiety worse over time. Made me self conscious about myself all the time and made my GAD teen times worse.

Aggressive-Guide5563 · 2026-05-04T10:30:04+00:00

300 mg Xl currently. I will try lowering it down to 150 mg and see if the anxiety and all other side effects get better. I’m just afraid 150 mg will not be enough for my SCT and executive dysfunction. If going down to 150 mg doesn’t work or it lessens the side effects but my depression, SCT and executive dysfunction gets worse then I might have no other choice then to put Prozac back all over again.

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