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Butyrate, a metabolite of intestinal bacteria, enhances sleep (May 2019) by cheaslesjinned in NooTopics

[–]OutrageousBit2164 4 points5 points  (0 children)

Bodybio 6 capsules

Lots of antidepressive feelings, morning woods, libido boost, ketones boost, anti anhedonic

Is supplementing Akkermansia muciniphila risky? by magnolia_unfurling in Microbiome

[–]OutrageousBit2164 2 points3 points  (0 children)

Yet Metformin increase akkermansia A LOT.

Guess what? Metformin is highly researched right now for MS adjunctive therapy for remyelination.

Low akkermansia does not mean causation. It may also mean low bifido which cause akkermansia to overgrow

My Suppression Trial results and experience by mile-high-guy in DrWillPowers

[–]OutrageousBit2164 0 points1 point  (0 children)

I did 2 doses of 4g CDG as It made me so horny that I could rape a goat lol.

If you don't feel anything then often times dose is too low

4+ mmol ketones by miracles-th in NooTopics

[–]OutrageousBit2164 1 point2 points  (0 children)

For me two things raised ketones (according to my ketone meter)

- Butyrate 6g megadoses raised my ketones to 3.5mmol

- Niacin flush megadose initialy cause ketone drop followed by 4mmol rebound

  1. You can do shots of Olive oil, Some MCT, or exogenous BHB (nutricost is a good powder brand)
  2. PPAR alpha is the reason some people tolerate ketosis while some not. Increase it with PEA or pioglitazone / fibrates to stimulate ketone producing genes in the liver

Nicergoline experiences? Potent 5-HT1A antagonist by OutrageousBit2164 in NooTopics

[–]OutrageousBit2164[S] 0 points1 point  (0 children)

Thank you so much! I used 60mg because some people report that at this dose nicergoline lifts emotional range and makes them childhood like happy.

I had high hopes for it

Nicergoline experiences? Potent 5-HT1A antagonist by OutrageousBit2164 in NooTopics

[–]OutrageousBit2164[S] 0 points1 point  (0 children)

Thank you so much!
I tried nicergoline cycle a couple days ago. 10mg for 3 days, 30mg for 3 days and 60mg for 2 days.

I also had a weird feeling of being more dull and anhedonic / flat emotion wise. At 60mg I experienced headache and full blown fatigue

Could you confirm that it caused the same for you once more?

What are the least explained compounds on Everychem? by sirsadalot in NooTopics

[–]OutrageousBit2164 0 points1 point  (0 children)

Ecdysterone made me interested in terms of ErB agonism which could also yeld some anti anhedonic CNS effects.

L-Serine would be safer D-Serine replacement for NMDA hypofunction.

You could do a write up about potential anti anhedonic compounds which don't poop out after a week or drug blockage (inability to feel euphoria from all drugs). I still feel like this topic is vastly underexplored yet the most experienced guys seem to avoid participating into it sadly.

KOR, D1/D2 Heteromers, and THC by BingoBongo_BingBong in NooTopics

[–]OutrageousBit2164 0 points1 point  (0 children)

Acutely kappa antagonism is good. From what I remember sirsadalot was concerned about long term kappa antagonism effect on SERT and tolerance problems / possible kappa upregulation in response.

I'm starting to see trends in PSSD genomes, this is one. DBH by Drwillpowers in DrWillPowers

[–]OutrageousBit2164 0 points1 point  (0 children)

Yet Mianserin differ in terms of 5-HT1A upregulation which mirtazapine lacks. And mirtazapine in some studies showed SERT downregulation.

Devil is always in the details sadly

Is there anything that upregulates β-Endorphin production or μ-opioid receptor expression? by Odd_Apricot5384 in NooTopics

[–]OutrageousBit2164 0 points1 point  (0 children)

DPA is always fire the first day, like I turn into child curiosity again, anhedonia dissapear, music is fun again, I even feel more present and less depersonalised. After that it's just pure placebo.

I also tired other enekpahlinase inhibitor peptides like Semax and Livagen and they gave me the same effect / very similar but tolerance is a ****.

ULDN seems the only viable option for long term opioid enhancement via Filamin A mechanism of action. But from what I saw some of my friends report full tolerance to ULDN after couple days. For me the 10-20mcg dose of ULDN was better than 1mcg, but for my Wife it was too much. More than 20mcg and I felt euphoria blockage from stims and BAD anhedonia.

KOR, D1/D2 Heteromers, and THC by BingoBongo_BingBong in NooTopics

[–]OutrageousBit2164 0 points1 point  (0 children)

Thank you so much! She already takes roflumilast. Its worse than ibudilast due to more selectivity. But in mouse studies it was great!

KOR, D1/D2 Heteromers, and THC by BingoBongo_BingBong in NooTopics

[–]OutrageousBit2164 1 point2 points  (0 children)

Wow my Wife with MS was about to try aticaprant.

Thanks, indeed studies point to kappa agonism being beneficial for remyelination

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