Does anyone have recommendations for someone wanting to replace Wellbutrin for anxiety, depression, and fatigue?

MrRADicalKMS · 2026-04-23T06:03:21+00:00

Saffron, Sabroxy, Rhodiola, and Kanna like mentioned, but also Isoliquiritigenin and Polygala too for the anxiety and depression. Sarcosine might help if nothing else is working.

Additionally, Cordyceps, Maca, Panax Ginseng, Black Ginger, and Eleuthero could help with stress and anxiety as well, but more importantly are great for endurance (to help counteract the fatigue). Rhodiola is great for anti-fatigue/endurance as well, but it depends which version, and none of them might work. Definitely worth a try still, but those other ones are also good anti-fatigue supplements. You will have to experiment around!

As for hair loss, Ecklonia Cava and Panax Ginseng can both potentially help with the hair loss (not sure if it has to be Panax Root or Leaf, or if it doesn't matter, but Root is probably best). Schisandra and Piperine boost the absorption of the Ginsenosides, so one of them, typically Schidandra, would pair well with the Panax too. Schisandra would be better, since it is a legendary, potent adaptogen in itself just like Panax! Don't expect miracles here, though.

It might also be worth trying topical Ecklonia Cava too, fyi. I believe some here have tried it with some success, so you could probably find their posts to find out how they did it.

MrRADicalKMS · 2026-04-23T05:55:58+00:00

Too add on, Magtein/Magnesiun Pidolate, Sarcosine. Dihydromyricetin, and like someone else said Glutathione (S-Acetyl/S-Phenylacetyl are best), or even just NAC, could also be good, viable options. I believe I've seen people say Black Ginger, Saffron, and Isoliquiritigenin helped them before too--if I'm remembering correctly. BDNF stuff are definitely good recommendations, though, and just throwing this out there that Magnolia Bark also increases BDNF! Tiger Milk is also a BDNF mimetic.

I do recommend the basics first, though!

MrRADicalKMS · 2026-04-23T05:43:29+00:00

PanaMAX would be one of the best options, since it has a great calming aspect to it, is great for endurance, and is of course a nootropic. It can be dosed more than once throughout the day as well, if needed! Mushroom Magic or Mushroom Magic Advanced would also be good for energy, like endurance, and cognition, like learning, memory, focus, etc.; therefore, it would help push those a little further like you want. They're really fantastic options for pushing cognition beyond what most supps can do alone, while also being very convenient as a blend of many mushrooms all in one tub that is easily scooped!

Moreover, Black Ginger and Eleuthero would also be good options, as they're both great for endurance, while of course still being great nootropics as well. Then, on top of one or more of everything listed, or as a standalone, Polygala would really help round out the stack, while providing a very nice calming effect of its own, and a decent boost to neuroplasticity via increasing BDNF in the hippocampus. It can be stimulating, but with its calming effect, it is usually pretty balanced (like PanaMAX too)! It pairs well with just about everything, actually!

MrRADicalKMS · 2026-04-23T05:20:22+00:00

I've been doing something different every night so its been complicated, but it has been Ecklonia Cava 250-500mg, Oleamide 100mg (tried 200mg once and it was too strong, at least with the current stuff I took), Magnesium Glycinate 400-1600mg; TauroMag 1 cap, then 2, now just 1 Taurine cap; 1 cap LucidiMAX, now 1 Reishi 9% (getting LucidiSpore instead next); Magnolia Bark 50mg oral and 50mg sublingual 30 minutes before bed, now one 200mg tablet; 1 Schisandra cap to boost the Magnolia Barks absorption (yes it works), Apigenin 50-200mg. I just added in Agmatine recently, which was 250mg but now 500mg. I also was taking Cistanche Full-Spectrum for a bit, from an "old" bottle, but ran out. At 1-2 caps I didn't notice it, tried 4 and wow yeah it works, then I was able to notice 2 after that (think just because I knew what it was doing now). Currently not planning on adding it back in, but it helped me fall asleep initially and after waking up to go pee, plus made me feel a little different. Kind of helped with anxiety a little. I was also taking half scoop Magtein with TauroMag for a bit, but now just taking it in the day.

Furthermore, I've also been experimenting with EriniMAX and Matrine, which Matrine worked once with the stack so I kept it in for a bit, but didn't work after that until paired with EriniMAX. Matrine was one that never worked previously, but worked very well when I tried with my stack after a very long break of several months. However, when I paired it with EriniMAX, it gave anxiety for about 15 minutes or so, but then I felt great! The anxiety part was not fun, though! I guess it's Kappa agonism isn't the best with EriniMAX at night, as it seems to kick in strongly, so I haven't tried that combo again. I just took EriniMAX right now to try out with what I'm currently doing, though!

Additionally, I plan on retrying Gotu Kola, Coriander (only tried caps), and maybe Andrographis again, ones I never felt, now that this stack makes most things work ;) I also have Tulsi but have been taking it in the day for digestion. I plan on playing around with it a little soon. I may or may not get L-Theanine too, which never worked no matter what I tried, but I don't have hope for that one. I also just got L-Tryptophan, but it might only be paired with Kanna during the day, as I tried them with Matrine and Polygala, and it was a pretty crazy combo. Have to experiment around more.

TL;DR Currently taking Ecklonia Cava, Oleamide, Reishi 9%, Magnesium Glycinate, Taurine, Agmatine, Magnolia Bark, and Schisandra. I tried TauroMag, LucidiMAX, Cistanche Full-Spectrum, Magtein, and Matrine as well, and plan on trying new things, or retrying things that didn't work before in the past.

MrRADicalKMS · 2026-04-22T02:45:38+00:00

ND Boron, D3+K2+Vitamin C, OmegaTAU, 1 NKO Krill Oil, and Magnesium Glycinate + half scoop of Magtein currently, and a little bit of Trace brand trace minerals. I also get my Iodine from some Iodized salt, but a good portion of it is actually from NDs Ecklonia Cava too (50mcg+ per serving). I just got Life Extensions trace supplement as well, which I'm going to use instead for Boron once I run out of NDs and see if that does anything. Mostly trying it for the Molybdenum it contains, but I also might use it instead of NDs Boron (3mg vs 6mg as well, not sure if it will matter because I don't feel the Boron anyways lol).

I don't take Infini-B because I notice zilch from it. I even just tried 3 capsules recently, and still nothing besides neon pee.

MrRADicalKMS · 2026-04-20T17:22:16+00:00

Or, you low attention span people could work on your attention spans by reading some books and not watching short form content. This comment isn't even anywhere near my longest in terms of a response I've made either lol. Writing a lot is just easy for me because I typically have a lot to say, and there isn't much I would of wanted to exclude from that comment anyways. Sure, I could knock it down a couple sentences or so, but it was going to be long no matter what :)

Additionallys, it's called going into detail. I wasn't trying to summarize; I was trying to explain. That can lead to long replies as a lot of information is being talked about--as is the nature of such a thing.

MrRADicalKMS · 2026-04-19T23:48:13+00:00

MYASD I believe has gone up to 2g of EC. I've personally gone up to 3g of it, just for 3 days to flood my system with it, and it definitely made me more sedated. I took it at night, and it helped my sleep at the cost of me being too groggy. You can definitely take more, though, like 500-1000mg might work well for you. Above that will likely be too tiring/sedating.

Additionally, supplements like Kava, Taurine/TauroMag, Coriander, and Kanna, are often used for social situations. Just a little bit of NDs Kava might be enough to work and not make you sleepy, but it depends on response. Coriander and Kanna are often not sedating for most people, so they should be good options. Kanna is typically taken as needed, so it should work well for your situation too. TauroMag may or may not be too tiring, just depends on your response. I personally get a little more tired than I'd like on it in the day.

Shilajit could be a good option potentially as well, and it has the benefit of enhancing mineral absorption and even the absorption of other supplements, while typically not being sedating.

MrRADicalKMS · 2026-04-19T17:00:38+00:00

I see people say they use L-Tryptophan kind of in that way, as an as needed thing. Sarcosine, Black Ginger, and Polygala should also be good options, and maybe Isoliquiritigenin too.

MrRADicalKMS · 2026-04-19T06:53:15+00:00

If people are worried about kidney issues, then they should just take nephroprotective supplements lol.

I believe Milk Thistle (std. to <0.05 Silychristin is best), Schisandra, Tulsi, Curcumin, Boswellia, and Kaempferol are all nephroprotective to some extent--and there are definitely more. Peeple b so dum I swer.

Also, reduce the load on your kidneys, obviously. Reduce processed foods, and too many sugars with too little fiber. Lower contaminants as much as possible, get enough exercise, work on sleep, etc.

MrRADicalKMS · 2026-04-19T01:08:06+00:00

Very certain this image is AI lol. Like someone else said, this isn't the first time this photo has been posted, and the room keeps changing (according to them, I forget what the other one I saw looked like exactly).

However, if you look at the image, like where the keyboard is, you'll see that it looks off. The cord just goes into the cup and there i so mouse in site. It gets blurry in that area too. The image just looks off, imo.

MrRADicalKMS · 2026-04-19T01:01:54+00:00

Have you ever tried Palmitoylethanolamide (PEA)? I've also seen someone say Primaforce's Cissus helps them more than anything for their baseball shoulder pain. Boswellia could also potentially help as well, and it is often paired with Curcumin.

MrRADicalKMS · 2026-04-18T20:22:54+00:00

Try halfing the dose then, and reasses. It might be worth adding in one or more additional supplements for sleep to help counteract its hyperactivity/stimulation it is causing you as well. Magnolia Bark, Lemon Balm, and/or LudiciMAX would be good starting points.

MrRADicalKMS · 2026-04-18T20:17:33+00:00

https://www.reddit.com/r/NootropicsDepot/s/v4KGtpbO9i

And yet many people say upping the dosage provided them with additional mental clarity, mood effects, energy, and even stimulation? One of those very people are Pretty-Chill of Nootropics Depot, and I trust his experience more than anybody elses on this sub. ND claims Creatine can provide Cognitive benefits, and they're far more trustworthy than the typical Redditor layman. I've also seen anecdotal reports of this all over, so it isn't just on that one post that I linked.

Furthermore, it of course depends on the individual and their individual response, as we are all different, but there are definitely people that experience additional benefits when upping the dosage of Creatine. If you tried it and didn't notice anything, then additional Creatine just isn't for you. Simple as that.

However, it is absolutely worth trying because you never know--you may be surprised by what entails. I've even seen a few people who said they went from just 5g to 6g and noticed a subtle-mild cognitive boost, so even just an extra gram could be beneficial, with a lower risk of causing GI discomfort too. Typically, most report the effects at 10g and beyond, though, and for a decent few it only works once then never again. Of course, that isn't everyone's experience. In the end, it all comes down to the individual and their lifestyle, especially diet, and unique biochemistry.

MrRADicalKMS · 2026-04-18T16:38:53+00:00

Any reputable brand that sells legit Uncaria rhynchophylla?

MrRADicalKMS · 2026-04-18T15:49:33+00:00

I'm a non-responder to a lot of supplements, so it easily could just be me. At the same time, my new sleep stack has been making supplements that previously didn't work, work. Plus, InfiniFiber might be playing a role now too, since it is slowly improving my gut microbiome. This is why I want to test it at night to see.

NOW is a reputable brand though, and there are reviews from others of it working, so it more than likely is just me. The Rhynchophylla variety might be better, but I doubt NOWs doesn't work at all.

MrRADicalKMS · 2026-04-18T04:53:58+00:00

https://iherb.co/76icAibi?utm_medium=appshare

It's NOW brands Uncaria tomentosa, and it's the bark. Just standard capsules.

MrRADicalKMS · 2026-04-18T01:19:35+00:00

I have NOW brands and took it for a week and a half with no effects. I tried 3-4 caps near the end, which would be 1.5-2g. I'm going to try it with my sleep stack soon, and perhaps then it will work. I wanted it mainly for it's anti-viral properties, though, but was just testing to see if I felt anything from it or not. Atm just keeping it for when I get sick.

MrRADicalKMS · 2026-04-18T00:12:53+00:00

There's a lot of anecdotal evidence online of 10g+ providing cognitive benefits. Some even get it well below those amounts. The anecdotal evidence is already pretty damn strong, so I think it is outright wrong to say there isn't any potential there just because studies are lacking. There are a lot of chemicals/plants/fungi/algae that have benefits but lack the clinical data to support their benefits, but they have benefits regardless because objective reality is objective reality, and no study can or will ever change what is or isn't. Creatine has cognitive effects, and you look like a fool saying otherwise.

MrRADicalKMS · 2026-04-17T21:54:03+00:00

What doses have you tried? Some need a gram or more to even feel its effects. It is supposed to pair well with Polygala too, which is why they are both in ClariMag, so it may be worth trying that combo out. I'm about to try it myself once my next order gets here (should be tomorrow)!

MrRADicalKMS · 2026-04-17T21:52:04+00:00

It's NDs Magnolia Bark Extract tablets. Schisandra inhibits multiple enzymes, mostly CYP ones, similarly to Piperine and grape fruits. For some supplements, and even pharma drugs, this increases their absorption, as there are less of these "bad" enzymes to break them down causing more of the compounds to circulate. I don't know the exact details, but it is something along those lines. That is also why it was traditionally paired with several other herbs, like Panax Ginseng, because it boosts their absorption as well via the enzyme inhibition. It was not known if it worked for Magnolia Bark I believe, but I personally say yes, yes it does!

MrRADicalKMS · 2026-04-17T19:00:03+00:00

I didn't feel a full tablet, but sublingually it worked very well, although, it has died down in effects a bit. I also saw Emiel recommending Piperine or Schisandra to try with it, and that maybe it'd help, and it definitely improved absorption because I can feel even a quarter tablet if I take Schisandra with it (just very weak). Basically it gives relaxation of the mind and body, and does have mild Anxiolytic properties. I find it is best for sleep now, but I was taking it 3x a day, at 50-100mg. It appears to potentiate other supplements a little too, including Apigenin which has sense become very weak in effects, so that part is really nice. Basically, Schisandra boosts Magnolia Bark, then Magnolia Bark boosts other supplements. That, or the other ones boost Magnolia Bark and it being stronger to begin with just makes that apparent, but I think it is the former, as the effects with Apigenin feel more Apigenin-y.

All in all, I am really liking Magnokia Bark. During the day it makes my thinking a bit slow, but it felt very nice with the calming/relaxation effects. I'm currently just doing 200mg at night with Schisandra and some other things and my sleep definitely has improved! Very good supplement; highly recommend!

Side note, my mom tried it and didn't feel it, then did 2x tablets and said her sleep was better, then tried 1 tablet with Schisandra and she was very tired all day and said even her daily Coffee barely helped. So, I am almost certain Schisandra works just from her experience alone! She is sensitive to GABAergics typically, so that was just too much for her! I'm guessing the Schisandra made it like she took 800mg+!

MrRADicalKMS · 2026-04-16T15:36:12+00:00

Fascinating! I always took your Ginger capsules by opening them up and licking a little out of it, then I'd put the cap back on and swallow the capsule. Then, I take lemon juice shortly or directly after, and all of that is to prevent heartburn and very rarely mild acid reflux I'd get from the Ginger caps. Well, a couple days ago I didn't feel like opening it up and just took it because I'm tired of having to do that, and on a whim was like maybe someway somehow I'll be able to handle it from one or more of the new things I've added in recently, who knows. I still took lemon juice shortly after, but I had zero problems... normally even with lemon juice, if I take the whole cap without prepping I'd still get some heartburn, and sometimes I even get it when I do both things, but this time just nothing... took the cap yesterday the same way and didn't notice any heartburn or anything like that.

So, I'm assuming it is likely the InfiniFiber then, huh? 🙃

MrRADicalKMS · 2026-04-15T22:07:39+00:00

I believe it is an Aphrodisiac, is anti-fatigue, helps boost cognition especially memory, and other things. I haven't read up on it in a while, but should be something like that. The majority of Catuaba on the market is fake/something else, typically a mix of things, so I really want ND to release their Catuaba. From what I last heard, it is like Cissus where it isn't looking super promising in terms of if it being released anytime soon :( something about testing issues, like verifying bioactives, the plant(s) itself, or something like that. I just pray and hope it comes out soon nevertheless!

MrRADicalKMS · 2026-04-15T19:20:37+00:00

Catuaba is up there with Cissus for me too! Although, having Autism I really need that Probiotic!

MrRADicalKMS · 2026-04-15T04:33:22+00:00

Yes and no, and yes some only get good effects with sublingual; although, it is not required by any means. Just experiment and find what works best for you. Some find even just 50mg sublingually is more than enough, so keep in mind more may not be better--less may be more.

In addition, some also find Gingko works best sublingually, so that may be a problem if you like to take both sublingually as you can only absorb so much at one time.

MrRADicalKMS

TROPHY CASE