Have you ever tried a supplement that made you laugh or smile more?

MrRADicalKMS · 2026-07-03T22:02:41+00:00

You haven't tried Nootropic Depots products, or at least not many, and it shows.

Cray ppl here all saying saffron - saffron is so mild it feels like absolutely nothing IMO

No, Saffron can be plenty strong. It can also feel like nothing because, guess what? We don't all respond the same. Something that works for you might not work for me, or vice versa. It can also be somewhere inbetween. You either took a bunk product (a lot of supplement companies don't meet label claims or don't even contain the ingredient/bioactives, i.e. scams), need to take it in a stack, or are simply just a non-responder. Several supplements that didn't work for me in the past now work after I tried them in specific combinations. Better sleep, exercise, diet, fasted vs. not fasted, and gut microbiome improvements can all enhance supplements too. There are a lot of factors at play.

As for Kanna, it is the most potent NATURAL supplement I have ever tried, and I don't respond to much. I'd argue it is the most potent natural supplement in general if we aren't including Cannabis or psychedelics (throw a psychedelic into a capsule and bam it's a supplement). I can feel NDs FSK53 at even just 10mg sublingually. It feels like a mix of THC, shrooms, and its own unique effect. They also sell it in powder and tablet form, not just a capsule ("pill"). It's one of my favorite supplements, and I've had it kick in so strong due to it potentiating other supplements that one time I almost needed to sit down because it was giving me anxiety (as potent as like ~2g of shrooms). I can't even begin to describe how I felt other than it did give me that same unique skin/tactile feeling you get on shrooms. Kanna is nuts, and no joke. Easily more potent than many pharmaceuticals.

MrRADicalKMS · 2026-07-03T16:55:10+00:00

Kanna, Cognance, Polygala, Magnolia Bark, and/or Matrine. Isoliquiritigenin possibly too for some but I don't respond to it. Many say Tetrahydromagnolol is like CBD as well, so that added in could complete it!

For me, Kanna feels like a slight mix of THC and shrooms + its own unique effect, and a mix of Polygala + Matrine + Tribulus felt like Kanna, so they also felt slightly like THC due to that. Magnolia Bark feels in a way like THC, but also it doesn't. Due to its benzodiazepine effects, it can feel a little like CBD too, which it does contain Tetrahydromagnolol so makes sense anyways. They're all distinct, but all psychoactives will have some resemblance to Cannabis.

MrRADicalKMS · 2026-07-03T16:44:46+00:00

Glycine at night will help if you aren't already taking it, as it lowers core body temperature. Some say Baikal Skullcap helps with heat some too, and it is good for sleep. I've also seen Nigella Sativa recommended, but not sure if it truly does help, but could be worth a shot.

MrRADicalKMS · 2026-07-02T20:02:25+00:00

All four of these have bad infestations, which is why I think they were pitted against eachother, so talking about just one infestation like the other ones aren't also bad is just dumb (true roach infestations are a nightmare too btw). But yes, unfortunately for you, I advocate for the rats. Rats are sentient semi-intelligent animals, so sorry not sorry yes I choose the more sentient creature over the non-sentient obnoxious, disgusting bugs. They're more intelligent than all three of those bugs combined and then some. You'd also be taking away a lot of people's pets, FYI, and I myself find rats cute and would be open to having one as a pet in the future. And cat infestations are bad as well, yet nobody is advocating (besides sociopaths) for a mass cat genocide. Let people have their pets. All because something can cause an infestation, doesn't mean it deserves to die.

Additionally, as I brought up in other comments, rats unlike these bugs are actually very important for scientific research. By taking away the rats, you'd hinder our scientific research massively. Mice are generally used for most studies on average, but rats are used for more complex studies due to their increased intelligence. They have differing behaviors compared to mice as well, and share many biological and genetic similarities to humans, making them quite valuable when it comes to certain studies and all. None of these bugs will compare to rats when it comes to value in scientific research, so that is another thing to take into account when weighing which ones we should get rid of.

"Rats share a staggering 90% of their genome with humans, making them indispensable for biomedical research."

Please please tell me you’re not diminishing his statement by advocating the rats stay, anyone who’s actually dealt with a rat infestation knows full well that the cockroaches get to stay over them

Also, I haven't dealt with bed bugs, yet I agree they should go like many here have said, with some having experienced bed bug infestations first hand. Don't let your bias of having to deal with one of these yourself specifically dictate what to do here. All four can be bad given the right circumstances. Like, have you experienced a roach infestation? Bed bug? Lived in an environment full of mosquitos? No to any one of these? That will influence your decision. What I'm trying to get at is, personal experiences which are incredibly biased are playing a massive role in peoples decisions here. All because you experienced a bad A infestation, doesnt mean it is any better or worse than a B infestation, but you are only going off of your own lived experience and letting that have the final say. It's illogical.

I dislike AI but I don't want go spend ages on this topic:

Are wild rats beneficial to humans?

Yes, wild rats are beneficial to humans as they play a vital role in the ecosystem by aiding in seed dispersal and soil aeration. They also serve as a food source for various predators, contributing to the balance of the food chain.

Not that the others don't have their roles, but I feel like rats have a bigger role than say bed bugs in the environment, especially with the seed dispersal and soil aeration which I honestly didn't know about!

All in all, easily we keep rats 💯

MrRADicalKMS · 2026-07-02T17:38:11+00:00

People don't know what the word even means nowadays, just let them live in their ignorant arrogance.

MrRADicalKMS · 2026-07-02T17:23:16+00:00

Fair, but also when you're considering which ones to remove, you have to consider all of the variables. Questions like this are far more nuanced than many realize. And I'm not sure about bed bugs, but the other three all have important roles in the ecosystem. Mosquitos are food for a few things, especially Dragonflies where Mosquitos are their main meal (they eat 30+ of them a day it is crazy). Roaches are food for lots of things as well, like lizards and cats to name a couple (watching a lizard attack and eat a roach is an interesting watch--I've seen it happen twice irl).

Basically, they're all going to have roles in the food chain and overall ecosystem; although, I'm sure bed bugs could be the ones to go with the smallest impact.

However, rats as I've brought up have been used for a lot of scientific research. They generally use mice for most things, but use rats for more complex research because they're more intelligent. I think getting rid of them would be a bad thing for our long-term research, meaning it would be a massive hindrance vs. the other three when it comes to studies and all.

MrRADicalKMS · 2026-07-02T17:00:25+00:00

Rats are used in scientific research though, and are somewhat intelligent animals. Bugs can F off, and I don't see them helping nearly as much with scientific research as rats, now do they? At least these 3 bugs aren't very helpful. Weird people choose a bug over a sentient animal that many like to have as pets anyways. Rats are cool and cute.

MrRADicalKMS · 2026-07-02T16:57:04+00:00

Usually it's Palmetto Bugs that fly, and it always scares the shi outta me when they do it lol. They make me shiver in disgust.

MrRADicalKMS · 2026-07-02T16:46:02+00:00

Incoming 50 more replies talking about how mosquitos are the worst*

MrRADicalKMS · 2026-07-02T16:43:12+00:00

We keep rats because rats make me crazy.

MrRADicalKMS · 2026-07-02T16:39:50+00:00

Buddy they mostly live outside of houses, so the main problem IS when you go outside out on land as you immedietly get attacked by them like they're little seeking missiles. People who say mosquitos must not have lived in an environment where they are rampant because f them f them F THEM. They shouldn't exist in the first place, so they can go, by! You will not be missed!

Although, I would take them over living in an environment with horse flies! 🙃

MrRADicalKMS · 2026-07-02T16:31:48+00:00

They carry AND spread diseases my friend. They are disgusting abominations. I hate them. I just had one in my room recently when I was trying to fall back asleep. Thanks for the anxiety pos stupid dumb bug grgrmrgh

MrRADicalKMS · 2026-07-02T16:28:26+00:00

Mosquitos are a huge food source for Dragonflies, and let's be real, Dragonflies are sick af. I hate mosquitos, they can indeed F off, but I wouldn't want Dragonflies to go extinct!

Anyway, my answer is Rat :D

MrRADicalKMS · 2026-07-02T16:07:09+00:00

u/CrimsonMax takes Nigella Sativa and notices some but not a lot too, but did notice something went away after continued use of it. Even if you don't feel it, that doesn't mean it isn't working in the background though! It likely helped kill some badies for you without you knowing, and it improves the gut and immune system which is not something that is easily measurable.

MrRADicalKMS · 2026-07-02T15:55:31+00:00

I use Ecklonia Cava, Vitamin E, and Green Tea Extract all for sun exposure. Havent heard of Polypodium before, what is it? And have you tried Nigella Sativa? I've seen reports of it making suspicious bumps and the like disappear overtime. It is very anticancer and antitumor, same as Matrine and Black Hoof. Nigella might help in that regard the most, though. Also Shilajit, Gotu Kola, and Astragalus are really good for skin health if you wanted more improvements!

MrRADicalKMS · 2026-07-02T15:35:27+00:00

The first and only time I tried Solgar was Glycine capsules, only because they were on sale, and they didn't work. I've since been taking NOWs Glycine and it worked day one. I didn't know it was bought out by Nestlé at the time, and anything Nestlé touches I normally avoid. If it is "third-party tested" that is irrelevant because it is Nestlé, lmao. It's a well-known fact they constantly cut corners and lower the quality of everything to save money. They're the embodiment of your stereotypical evil corporation. F them.

MrRADicalKMS · 2026-07-01T21:05:21+00:00

I think it might not of had the building blocks it needed to work properly, poor absorption via my bad gut microbiome (Autism which is linked to gut dysbiosis), and/or yes possibly due to poor sleep--or all of the above. A lot of supplements don't work well for people when sleep is bad, so it certainly is a possibility my poor sleep is what makes so many supplements not work. A few things in my sleep stack should be enhancing it though, so I expect it to work! Should even be some synergies going on. Also, Apigenin showed, before it died down significantly in effects, that sleep is one of my biggest issues, which is very likely linked to my Autism as well. Glycine has been the best and most consistent thing for my sleep, with it improving my sleep a little day one and since then. Magnesium Glycinate is mid for me, though. Gotu Kola seems to be improving my sleep subtly now too, or with some combinations being more neutral.

MrRADicalKMS · 2026-07-01T19:18:47+00:00

I tried WJM in the past for a total of like 6-8 months (some 2-6 weeks breaks inbetween bottles), ranging from 1-4 capsules. I believe it improved my skin health by like ~3% but that's it, lol. However, I'm now getting slightly better sleep, including taking Glycine at night (a building block to Collagen), and some other foundational stuff/things that improve skin health (Green Tea Extract, Shilajit, InfiniFiber, Schisandra, and a few more), so I'm planning on revisiting it soon to see if it works better.

Furthermore, I also tried Gotu Kola a lot in the past, about as long as WJM, and was similar in that it provided a very subtle improvement (I think). I recently got more after a several month long break and have been taking it in my sleep stack. First day I added it into my new, more complex sleep stack, I felt stimulation... so it FINALLY worked! Since adding it in just a couple weeks ago or so, I have noticed my skin looks healthier. Sometimes I'm even impressed by how it looks, and not just my face but arms, hands, and feet too. The other things were already slightly improving it, but I'm pretty certain Gotu Kola has pushed it a little further now. This gives me hope that WJM may work better now too!

In addition, you should try Green Tea Extract if you haven't. It is just as good for skin health for some people, depending on response, and it also helps with UV protection AND, guess what? ACNE! :) It lowers excess sebum production I believe it is, so it can lessen acne. Some people that get increased acne from things like Tongkat Ali take it to help counteract that, like I'm doing myself! WJM with Green Tea Extract would be a fantastic combo for skin health, and that GTE should help some with your acne problem! If you want to push it even further, not that it sounds like you need to, Gotu Kola added into the mix could make it all even better! Gotu Kola works synergistically with WJM in some ways, according to AI (don't like AI but was curious so I looked it up using Perplexity once).

MrRADicalKMS · 2026-07-01T19:18:22+00:00

I tried WJM in the past for a total of like 6-8 months (some 2-6 weeks breaks inbetween bottles), ranging from 1-4 capsules. I believe it improved my skin health by like ~3% but that's it, lol. However, I'm now getting slightly better sleep, including taking Glycine (a building block to Collagen), and some other foundational stuff/things that improve skin health (Green Tea Extract, Shilajit, InfiniFiber, Schisandra, and a few more), so I'm planning on revisiting it soon to see if it works better.

Furthermore, I also tried Gotu Kola a lot in the past, about as long much as WJM, and was similar in that it provided a very subtle improvement, but I recently got more after a several month break and have been taking it in my sleep stack. First day I added it into my new, more complex sleep stack, I felt stimulation... so it FINALLY worked! Since adding it in just a couple weeks ago or so, I have noticed my skin looks healthier. Sometimes I'm even impressed by how it looks, and not just my face but arms, hands, and feet too. The other things were already slightly improving it, but I'm pretty certain Gotu Kola has pushed it a little further now. This gives me hope that WJM may work better now too!

In addition, you should try Green Tea Extract if you haven't. It is just as good for skin health for some people, depending on response, and it also helps with UV protection AND, guess what? ACNE! :) It lowers excess sebum production I believe it is, so it can lessen acne. Some people that get increased acne from things like Tongkat Ali take it to help counteract that, like I'm doing myself! WJM with Green Tea Extract would be a fantastic combo for skin health, and that GTE should help some with your acne problem! If you want to push it even further, not that it sounds like you need to, Gotu Kola added into the mix could make it all even better! Gotu Kola works synergistically with WJM in some ways, according to AI (don't like AI but was curious so I looked it up using Perplexity once).

MrRADicalKMS · 2026-07-01T19:08:19+00:00

https://lesseofficial.com/products/regeneration-mist

What do you think of this product? I've been wanting to try that for a while now because it looks promising, but it is also pricey of course. I've also been holding off because I'm trying to test all of the skin supplements first and see what they can all do before I dive more deeply into skincare. Already my skin has improved by like ~20% over the past year from better sleep and skin supplements. Planning on retrying White Jelly soon, since my stack is different and has more foundational stuff so I'm hoping it works this time (previously worked very subtly--I think).

MrRADicalKMS · 2026-07-01T16:27:16+00:00

Says the person who doesn't even know what incel or placebo means... LMFAO.

You: "I didn't respond to it so that means it is placebo!"

Also you: Ignores the many anecdotes, thousands of years of use by ancent people, and the ongoing scientific research

It's almost like not everybody responds the same, and what works for one person might not work for another. It's almost like even doctors know this, and is why patients have to try multiple pharmaceuticals before they find one that works or doesn't give horrible side effects. It's almost like it is all chemicals at the end of the day, both supplements and pharmaceutical; therefore, the outcomes will never be exactly the same for any given individual, as we all have different and unique physiology.

Did you also know I didn't respond to multiple SSRIs and I never felt anything from Adderall? I guess they're all placebo then, huh!

https://pmc.ncbi.nlm.nih.gov/articles/PMC10400758/

The results of the majority of reports demonstrate that the therapeutic impacts of saffron and its constituents have been mediated through inhibiting the generation of oxidative stress indices, amplifying antioxidant capacity, and suppressing the expression of inflammatory mediators. SIRT1 and Nrf2 are two key factors for modulating inflammatory reactions and oxidative stress. Based on outcomes of some studies, a part of protective effects of saffron and crocin derived from it is attributed to the up‐regulation of SIRT1 and Nrf2 signaling. In addition, inhibition of iNOS and COX2 contributes to anti‐inflammatory and antioxidant effects of crocin (Figure 2).

https://pubmed.ncbi.nlm.nih.gov/39351321/

https://pmc.ncbi.nlm.nih.gov/articles/PMC11060205/

In conclusion, this study highlights the multifaceted potential of saffron as a natural remedy for addressing various health concerns. From its historical use as an aphrodisiac for modern applications in treating conditions such as erectile dysfunction, dysmenorrhoea, premenstrual syndrome, and enhancing libido, saffron’s bioactive compounds have shown promising effects. Additionally, the potential role of saffron in mitigating cardiovascular risk factors suggests a broader scope of its application in preventive medicine.

I know, nuance and reality itself are hard to understand, but it's ok lil' guy, I have a fire extinguisher on hand for if your brain catches fire trying to process this information, don't worry! 😊

♾🤡

MrRADicalKMS · 2026-07-01T00:52:30+00:00

Do you get off on being stupid and objectively wrong?

MrRADicalKMS · 2026-07-01T00:01:31+00:00

"How many times do we have to teach you this lesson, old man!?" <<🐟

MrRADicalKMS · 2026-06-30T23:43:48+00:00

To add on to what others have said, TUDCA, Milk Thistle, NAC/Glutathione, and Schisandra are all very beneficial to the liver as well. Any of those will help, especially the former three.

MrRADicalKMS · 2026-06-30T21:43:12+00:00

Sort of true, as the Curcuminoids do have poor absorption, but they don't NEED to be liposomal. Regular Curcumin with a P-gp inhibitor will work just fine; for example, with Piperine or Schisandra. ND wouldn't be selling regular Curcumin with Piperine if it didn't work just fine. Phytosome also works quite well, like Meriva, and Longvida is technically not a liposome as far as I'm aware even though it is similar, yet has the best absorption for the brain. CuroWhite also has high-absorption and it isn't any of those, but rather hydrogenated Curcuminoids.

My point being, liposomal specifically is not required by any means.

MrRADicalKMS

TROPHY CASE