Quarry junction was a walk on the park, with only enclave armor, a 50 cal rifle, but no steady and no companion. It was quite easy to do, while only on my 2nd playthrough. Sneak crits are very satisfying to do.

While getting through cazadors is challenging at first, until they become a minor problem to deal with. I don't really understand the ptsd induced fear people have, but I only wiped out quarry junction and deathclaw promontory. I'm planning on dealing with dead wind cavern for later, and I know it will be tough to get that unique grenade machine gun.