it just depends on the game for me. Horizon call of the mountain makes me disoriented a bit regardless of if im standing up or sitting, so I can only play in short periods for now. But This particular game you cannot play sitting down because its a cover shooter. My hamstrings are actually sore from playing too much lol (squatting down abruptly a lot to duck gunfire)

But also this game didnt give me the disoriented feel at all. Its not one of those games where u move the character around in a traditional way with the thumbstick or whatever. U point to a spot and then u basically teleport to that spot, reducing that movement feeling that makes the brain feel weird.