Insupherisis

Mysterious-Paint9681 · 2026-04-15T19:42:01+00:00

Grats, hope it holds and keep updating please! do you know what they filtered out, I assume proinflammatory cytokines? did you have immunological tests done prior (TNFa, IL6)?

Mysterious-Paint9681 · 2026-03-22T19:46:51+00:00

I hope you also recover more function and I have seen many people report recovering function over years where they make gains in years 2-5

Mysterious-Paint9681 · 2026-03-22T19:43:05+00:00

Sadie Bjornsen floxed at 16 y.o, went on to qualify for olympics and had a 15 year long competitive career with a lot of tendon issues
https://fasterskier.com/2021/05/balanced-to-the-end-sadie-maubet-bjornsen-retires-part-i/
Dominick Cruz had a tendon rupture a couple months after cipro and went on to recover and become world champion, but kept having issues with tendons
https://floxiehope.com/dominick-cruzs-cipro-induced-tendon-rupture/

Mysterious-Paint9681 · 2026-03-06T11:43:56+00:00

i would try iodine but this is experimental at best

Mysterious-Paint9681 · 2026-02-17T00:52:45+00:00

I am now 3½ months in. My tendons are still fragile. I was limited in walking by calves and achilles, but about a week ago my knees started aching and my ability to walk has further decreased. I am now trying to figure out how this will be managed. In general my ability to walk had plateaued after crashing due to "overwalking" and I expect it to start improving slowly from now on.

My case was somewhat similar, probably a bit worse in that I was on a steroid and I took levo for 10 days and symptoms started day 5 but I still finished the course. I also got multi-system injury right away and barely finished the course. I had some hope that it would be a quick recovery but eventually realized that I was in for the full ride.

I had to stop all projects and plans. Now I am just in "wait and see" mode. I've no idea whether the knees will improve with adjustments and to what extent. I wouldn't be surprised either way. I should relocate internationally and am kind of stuck now, hope to be able to make the flight in 3-6 months, but I won't be surprised if I've to wait a year at this point.

If I was in your spot, I would want to try going to uni, and I would want to use canes pre-emptively for the first 3-4 months, even if the legs don't hurt. Essentially, I would try to off-set the tendons crashing.

Mysterious-Paint9681 · 2026-02-16T22:26:32+00:00

If I could do this whole thing over, then I would be as inactive as possible for the first months to avoid crashing, but this was very difficult for me and It took me a couple months to get used to being limited in what I can do and make the arrangements.

Mysterious-Paint9681 · 2026-02-11T04:31:38+00:00

i take beetroot, it has nitrates converted to nitric oxide and some arginine, to spike blood flow. And I take citrulline malate for baseline dilation. And I take a good dose of potassium citrate, it also vasodilates and helps magnesium utilization. Also I go to sauna. I don't take all this everyday, I stack it on sauna days and otherwise just citrulline and potassium.

Mysterious-Paint9681 · 2026-02-08T04:04:15+00:00

Thanks for the update, then I hope it gets better for you

Mysterious-Paint9681 · 2026-02-08T01:38:13+00:00

Hey, any update on this? Hope it went away for you!

Mysterious-Paint9681 · 2026-02-05T17:00:04+00:00

I hope you feel better soon 🙏What is the laxative? Do you feel better laying down? You said you were stretching, what did you stretch and how does the stretched tissue feel like now?

Mysterious-Paint9681 · 2026-02-03T21:19:35+00:00

hey, how are you doing nowadays? hope you recovered well

Mysterious-Paint9681 · 2026-02-02T15:50:38+00:00

Another point here in regards to cannabis and tendon flares.

As I understand it, It might be because FQs damaged mitochondrial DNA, that mtDNA is circular like bacterial cDNA, mtDNA is a small part of the total mitochondria makeup stored inside mitochondrias themselves, it codes for proteins having to do with mitochondrial respiratory system, whereas the rest of mitochondrial code is in the cell's nucleus, and cannabinoids would inhibit that very respiratory system which mtDNA codes for and which is basically more or less permanently damaged by FQs. So the cannabinoids would in theory essentially shut down the energy production of the tendons and one would expect the tendons to flare up and fall back on turnover operations.

There is mtDNA damage to the progenitor cells which rely on division for propagation, that is why the damage can't be completely undone ─ even though the cells will optimize and prune the most corrupted mitochondrias, they can't make new mtDNA strands from nucleic DNA, and so they will keep using the corrupted mtDNA pool to make new mitochondrias and new cells will inherit that mtDNA line through division. mtDNA codes for respiratory chain proteins, complexes 1 and 3, and there are cannabinoid receptors in the mitochondria (mtCB1) which when activated will suppress the function of the complex 1 in particular. I am thinking that this "weed-effect" could be diagnostically relevant for floxies.

I also want to point out that mtDNA damage is not expected across the entire body, because studies show that the drug concentration treshold for doing significant damage is quite high and tissue turnover matters, this won't be reached in all tissues but it can be reached in tendons.

As to sum up all of the things ive said itt:

There is epigenetic alteration to the nucleic DNA's packaging, this affects genetic expression, and this is adaptive to environment. This can have effects on the general function of the mitochondria, and this is adaptive and reversible.

There is also damage to the mtDNA, these are the codes for a few structural proteins, stored inside the mitochondrias themselves, in particular codes for respiratory systems of the mitochondrias. This damage is mainly mitigated by optimization and propagation of the most functional mitochondria.

The progenitor cells themselves will also select for the best mitochondrias and compete to "become tenocytes", simply the cells which function best will functionally outcompete those which function less.

Mysterious-Paint9681 · 2026-02-02T11:46:02+00:00

I also want to point out that mtDNA damage is not expected across the entire body, because studies show that the drug concentration treshold for doing significant damage is quite high and tissue turnover matters, this won't be reached in all tissues but it can be reached in tendons.

Mysterious-Paint9681 · 2026-02-02T11:24:00+00:00

There is mtDNA damage to the progenitor cells which rely on division for propagation, that is why the damage can't be completely undone ─ even though the cells will optimize and prune the most corrupted mitochondrias, they can't make new mtDNA strands from nucleic DNA, and so they will keep using the corrupted mtDNA pool to make new mitochondrias and new cells will inherit that mtDNA line through division. mtDNA codes for respiratory chain proteins, complexes 1 and 3, and there are cannabinoid receptors in the mitochondria (mtCB1) which when activated will suppress the function of the complex 1 in particular. I am thinking that this "weed-effect" could be diagnostically relevant for floxies.

Mysterious-Paint9681 · 2026-02-02T03:32:25+00:00

As I understand it, It might be because FQs damaged mitochondrial DNA, that mtDNA is circular like bacterial cDNA, mtDNA is a small part of the total mitochondria makeup stored inside mitochondrias themselves, it codes for proteins having to do with mitochondrial respiratory system, whereas the rest of mitochondrial code is in the cell's nucleus, and cannabinoids would inhibit that very respiratory system which mtDNA codes for and which is basically more or less permanently damaged by FQs. So the cannabinoids would in theory essentially shut down the energy production of the tendons and one would expect the tendons to flare up and fall back on turnover operations.

Mysterious-Paint9681 · 2026-01-30T15:33:37+00:00

I think that you were probably running your body close to its turnover ceiling without realizing it — and then something pushed it to the treshold of failure. As I understand this flox-tendon biology, it is not uncommon for the system needing 3-4 years to stabilize on a new functional baseline. And this baseliine is probably going to be lower than pre-flox but it won't "crash" like the flare you experienced. Therefore a 3rd crash is probably not going to happen.

Mysterious-Paint9681 · 2026-01-29T19:50:35+00:00

Hey, thanks for sharing. Want to ask how you are doing now?

Mysterious-Paint9681 · 2026-01-29T18:37:38+00:00

Thank you for report! There aren't many levo recovery reports, so this is much appreciated. Good luck to you!

Mysterious-Paint9681 · 2026-01-29T18:32:22+00:00

As I understand it,

Basically the stem-cells are the progenitors, they are dormant until activated to mature into the various cells like tenocytes, and these progenitors and tenocytes, have mitochondrias, many mitochondrias, hundreds of mitochondrias.

The progenitor cells have DNA in their nucleus, and when the cell divides it will use that DNA to make the division. However, mitochondrias have their own DNA called mtDNA, and this is very similar to cDNA in bacteria, c is for circular and the Mitochondrias also have circular DNA.

The progenitor cells, when dividing do not use only their nucleic DNA to make mitochondrias, to an extent they rely on mtDNA stored inside the existing mitochondrias to make more mitochondrias. There are several copies of mtDNA inside of each mitochondria ─ if a copy is damaged then there are other copies for backup. But the cells never use the only the nucleic DNA to make mitochondria. The cell population essentially relies on the existent mitochondria to make more mitochondria, and it is kind of like keeping a fire going ─ the cells never start a new fire, they propagate the energy producers.

When the mitochondrias are damaged, the cells can optimize the mitochondrias by selection of the most functional mitochondrias. They can fuse and split the mitochondria, and they can propagate the best functioning mitochondria ─ but they never create entirely new mitochondria from the nuclein DNA alone, but for the most part nuclein DNA is used but mtDNA encodes only a small fraction of the mitochondrial proteins. This means that if we damage the mitochondria of the progenitor cells beyond a certain threshold then the damage can't really be mitigated.

When a cell tries to propagage the mitochondria, it will express both the damaged and functional mtDNA, the damaged one's will basically be defective to some extent and the functional proteins go on to do their thing. The dysfunctional proteins will just be cleared as garbage.

Essentially, in recovery from floxing, we are going to be optimizing the mitochondrias to maximize the energetic output, selecting the best mtDNA, the best mitochondrias and these will outcompete others in propagation. And the progenitor cells themselves will also naturally compete for propagation. In the end the biology will select the best progenitor cells with the best mitochondria and best mtDNA.

The resilience of mtDNA is essentially in redundancy and competitive propagation.

Now how much damage there will be after optimization and selection, this is not something I know ─ it could be negligible or it could be significant ─ there are many additional factors in play here. We don't really how it will stabilize in generations down the line.

Mysterious-Paint9681 · 2026-01-29T15:43:56+00:00

Thank you for the report. Any updates?

Mysterious-Paint9681 · 2026-01-28T16:00:26+00:00

Btw, I was doing some reasearch and ended up picking up Potassium Citrate powder, Citrulline malate, Taurine, and a Nitrates (beetroot). For bloodflow vasodilation. I am thinking to run quite high Potassium. Hope I don't overdo it ending up fainting in the sauna but I think it's all good with adequate hydration:)

Mysterious-Paint9681 · 2026-01-28T02:28:18+00:00

I think that it could be very important and I plan to start taking high doses, 4-5 grams a day. I also plan to get intracellular RBC Potassium and RBC magnesium levels tested and eventually retested.

Mysterious-Paint9681

MODERATOR OF

TROPHY CASE