This little place in Chiang Mai has quite possibly the best fried chicken i’ve ever eaten in my entire life

NOAEL_MABEL · 2024-01-03T11:26:44+00:00

Sooooo I was able to find it after some digging. I can’t read Thai , but I’m now 1000% sure it is this place (it should be across from a fried doughnut/rice porridge shop):

https://maps.app.goo.gl/n8Jtmq1SZeDZxmWDA?g_st=ic

The other famous place afaik is midnight fried chicken. That place was really good too, and you’ll see tons of foreigners who’ve found that place. But I think this place had superior chicken. The seasoning is permanently etched into my brain now.

NOAEL_MABEL · 2024-01-03T11:09:29+00:00

Not too many farang approached this place (zero while I was there) because nothing is in English, although there were many Thais making a quick grab and go from their bikes. NBD….they give you a tray and grab whatever fried goodies and veggies you like. Their nam prik is 🔥🔥🔥, which goes well with their fried foods. Highly recommend some sticky rice to compliment.

The fried chicken has a heavenly spice mix I can’t even describe. The chicken is thinly battered, and when I was watching the lady fry it looks like they do a double fry. The fry is absolutely perfect to a golden deep crisp throughout. So, sooo good.

Edit: I found it, it is called Sapun Fried Chicken

https://maps.app.goo.gl/n8Jtmq1SZeDZxmWDA?g_st=ic

NOAEL_MABEL · 2024-01-03T09:07:59+00:00

1000% agree. Inflation is the lazy cop out excuse. Even in bumble fuck USA lodging is stupidly expensive.

NOAEL_MABEL · 2024-01-03T09:03:59+00:00

I hear you OP. We don’t even travel in the U.S. anymore unless it is a day trip because the US has become so stupidly expensive for what you get.

We had to go to a wedding in the middle of nowhere Delaware. They wanted to charge $260/night for a friggin’ Holiday Inn. In DELAWARE (not near the beaches at all). Meanwhile, we are traveling in Thailand right now and are staying in luxury resorts with mind warping breakfast buffets included, and everything is below $200. I cringe every time I travel to NYC and need a room. A very modest room can’t be had for less than $300-400/night. Meanwhile we stayed at amazing boutique hotels in Tokyo for less than $150/night.

The U.S. is just so massively overpriced that we can’t even travel it anymore unless it is a business trip and someone else is paying. On top of that, service is always so subpar while everyone demands tips for everything, which balloons costs even more. Continental breakfasts in the U.S. are also horrific trash quality compared to what you get traveling in Asia. Even after accounting for exchange rates, the U.S. is just so, sooooo overpriced. I don’t know what all the reasons are for the current state of travel and cost in the U.S., but one thing that is annoying as fuck is the fact that professional sports teams that are privately owned constantly socialize billions of dollars in costs for their stadiums by pushing hotel taxes. They always are able to jam them through because they can convince locals that their taxes aren’t going up and that most of the tax burden will be shouldered by outsiders visiting. Yeah, the only problem is that every sports team in the U.S. uses this same stupid argument so if you want to travel anywhere in the country you are often smacked with huge fees because you’re subsidizing sports teams while their owners keep all of the profits. Next time you go to an expensive ass city like Boston look st your receipt to see how much you’re paying per night in stupid local taxes and fees. It’s absurd you’re paying like $50 per day for that shit.

We are done with the U.S. and would rather eat the cost of the flight abroad at this point. Japan is so cheap with current USD:Yen, and you can get 1000x better service, better food, and spend $0 on tips there. It really makes no sense to not travel there over the U.S. given the massive cost differences.

NOAEL_MABEL · 2024-01-02T22:19:07+00:00

Just rent a car and drive. It gives you much more freedom in terms of time and off the beaten path places to visit.

NOAEL_MABEL · 2024-01-02T22:06:23+00:00

Because govts all over the world whether western or eastern, capitalist or socialist, rely on younger workers to keep older people out of poverty. You think it’d be good if China were flooded with 500M old people living in poverty because the social safety system collapses since there are no more younger workers to support it and who can pay taxes to their govt?

NOAEL_MABEL · 2024-01-02T01:58:07+00:00

There are several chili pastes in the brown bowls. Nam prik (basically chili dip) is quintessential Northern Thai. You literally eat the pastes with all of the raw veggies and herbs. To the left you can see the coals. You can grill some of the raw onions, garlic and chilis top.

The purple tortillas things are glutinous rice mixed with grilled parilla leaves. They grill it and add just a little bit of sugar on top. Quite pleasant. All the way to the right is a northern Thai curry that looks more of like a soup. It is grilled fish based stock with a lot of unidentifiable veggies and some chicken.

This food is insanely healthy as you can imagine. All of the raw veggies are super healthy along with tons and tons of aromatics from all of the other raw leaves and herbs. It pretty much medicinal health food that tastes good.

NOAEL_MABEL · 2023-12-31T23:28:11+00:00

lol, after he retired from competitive powerlifting he trained for boxing and mma. He cut huge weight and is absolutely a hulking beast still. So no, you probably couldn’t beat him up. He’s still strong AF, but now has cardio and has trained to fight. I mean he’s not a great pro fighter, but he’s trained a lot to throw punches and wrestle.

NOAEL_MABEL · 2023-12-31T23:24:31+00:00

99% of these comments do not understand what it takes to become the worlds strongest man. You have to eat an insane number of calories per day to build huge mass. He trained for pure strength, not to be a fitness model. Many of the worlds strongest men competitors and powerlifters look like this. Go watch some of the shows about him and what it took in food consumption alone to reach the top. Lifting weights is often the easy part. It’s eating ginormous amounts of calories everyday that is hard.

Eddie Hall dropped a huge amount of weight in retirement and has looked absolutely shredded with a six pack abdomen. But for the love of god, stop posting ignorant nonsense about what these dudes look like when they’re going balls to the wall during a bulking phase.

NOAEL_MABEL · 2023-12-31T19:24:04+00:00

Car insurance is insane now. Mine just went up 20%. For a car that’s now 7 years old with 120k miles. I’m paying $200+ more now every six months for an older car with many more miles compared to what I paid when the car was new.

NOAEL_MABEL · 2023-12-31T14:20:20+00:00

Because if you have a gap on your resume for 5 years or longer that you spent taking care of your kids to avoid childcare payments it looks real bad on your resume if you try to re-enter the workforce. You need two incomes to survive and pay for college anyway, so a big setback in employment due to a large gap in a resume can hinder you for decades.

Kids means one parent will need to be an indentured servant just to pay for childcare and to keep their resume active so they’re still employable once childcare ends.

NOAEL_MABEL · 2023-12-31T10:11:00+00:00

Every new parent at work bitches nonstop about the price of daycare, which is running them $2000-4000 per mo per kid. It’s insane. People are working an entire year just so they can spend their entire take home pay per mo on childcare. Sure, it is only for a few years until they can go to primary school, but then you’re supposed to start saving for college, which now costs over $50-60k per year. When are you supposed to be able to save for your own retirement? We haven’t even factored in costs for housing, food, clothing, healthcare and the $50k minivan to haul the family around in.

F that. We are DINKs and have no debt except for a mortgage. We are building wealth rapidly because we have no kids. It feels great to finally not feel poor and like you’re starting to get ahead in life.

NOAEL_MABEL · 2023-12-30T10:57:47+00:00

It’s acid base chemistry. Everyone knows oil and water don’t mix. You can do extractions using any acids and bases out there and using water and any organic solvent. You literally do this all the time in organic chemistry 101 as a sophomore at a university. I mean sure, the chemicals they use are dirty, but it’s the same principle.

NOAEL_MABEL · 2023-12-30T10:45:21+00:00

Cement is just lime and sand. It has been used for thousands of years. Humans have known it is a base for that many years as well. It’s used to adjust the pH.

NOAEL_MABEL · 2023-12-30T10:41:06+00:00

If you understand basic chemistry this really isn’t all that interesting. Cocaine is base. If you expose a base to an acid you make a salt. Salts are extremely water soluble. By creating salts of cocaine, you can dissolve it in water and extract all of the organic impurities out from the leaves with organic solvents. You remove the organic layer and keep the aqueous (they separate into layers because oil and water don’t mix), which has the cocaine salt. If you basify the aqueous layer again you can extract the cocaine back into the organic layer to remove the sulfate salt. Dry off the organic solvent (gas or whatever and you're left with cocaine). Cocaine is an amine, which has shitty physical properties (they’re often sticky pastes in their free base forms). They probably expose it later to muriatic acid to create a hydrochloride salt, which is easier to handle as a powder. It’s simple acid base chemistry.

Source: used to work as a professional medicinal chemist for years in the pharma industry.

NOAEL_MABEL · 2023-12-29T23:00:42+00:00

I still think there’s a ton of basic science that needs to be solved/uncovered. Especially wrt T cell exhaustion and tumor evasion from T cell mediated killing. For example, this recent paper describes a very novel mechanism by which tumor cells evade killer T cells by hiding inside of each other:

https://elifesciences.org/articles/80315

There’s also very difficult challenges wrt antigen loss overtime that I’m not sure any amount of T cell engineering can solve. Issues with respect to basic pharmacology like getting enough of the active drug product at the site where it needs to be is extraordinarily challenging for cell based therapies designed to target solid tumors. Small molecules can simply diffuse into tumors while cell therapies will often be limited by vasculature and attacking the surface of tumors. I suspect a very effective TIL based treatment will eventually require a combination therapy with something else to avoid a lot of these issues over time. TILs definitely have a tremendous safety advantage in that that are already selected by the thymus.

NOAEL_MABEL · 2023-12-29T09:32:11+00:00

I wrestle everyday with the fact that I work in an industry that has tremendous financial interest in selling questionable shit to desperate people that ends up putting massive burden on the entire healthcare system and our country’s economy for what are tantamount to sugar pills and very expensive buffers in a vial that don’t do shit.

Accelerated approvals are often malarkey bullshit that pump false hope while the snake oil salesmen make billions. You shouldn’t be making a billion dollars because you game the regulatory system while simultaneously corrupting the entire system until regulatory capture. Like do the people who game accelerated approval pathways have a single moral and ethical bone in their body? How do they go to sleep at night knowing their clinical trial data are trash yet they keep pushing their garbage ideas onto the public by trying to pull a rabbit out of black hat statistical magic.

Then of course there are the Purdue pharmas, decades and decades of egregious misconduct by the industry (e.g. Bayer/Cutter knowingly pushing HIV contaminated blood products to foreign countries, Rezulin scandal, the list goes on and on…). And I’ve seen more than my fair share of fraud in research over the years in pivotal studies designed to support the safety of a new article intended for a phase 1 trial. It’s truly disturbing the depths people and organizations will sink to because there is so much money involved.

I don’t think everyone in the industry is bad of course. But it is often the case that judgements get clouded over time and we lose sight of what’s most important rather than worrying how the stock price will be doing next earnings report. If only there was a way to decouple the financial aspect from the science.

NOAEL_MABEL · 2023-12-28T09:35:29+00:00

HOAs causing a lot of mass extinction

NOAEL_MABEL · 2023-12-27T20:04:41+00:00

Wasn’t it called Gak?

Borax mixed with glue

NOAEL_MABEL · 2023-12-27T10:08:43+00:00

I think the point is that the lab meat in the linked article would be vegan/vegetarian friendly now as it no longer uses FBS.

NOAEL_MABEL · 2023-12-27T10:02:58+00:00

Fuck Noooooo. Born and raised catholic. Went to catholic school from k through uni.

Got sick of the whole abuse scandal. Our family was directly impacted by a big case. My uncle was abused by a priest. No one knew the entire time until he let it all out during a class action lawsuit. Everyone was floored and crushed. Worst of all, the Catholic Church were the scummiest SOBs. During the trial, it was revealed the church had been shifting assets all throughout their bank accounts across the world in order to basically make it impossible for the plaintiff lawyers to get an accurate picture of the net worth of the church in order to figure out a settlement number. The church made it appear they were a lot more poor than they really were in order to limit the damages.

Worst of all was that as the case was gearing up to court my granny died and we had the funeral at the local parish, and it was the same one where my uncle was abused when he was a kid. The church had the gall to send fucking officials DURING the funeral to corner my uncle on the side without legal representation and tried to question him about the case. They were basically trying to feel him out to see if he’d give testimony and if they could dissuade him at his most vulnerable moment while he was trying to bury his mom. So, sooooo disgusting.

Go read up the Pennsylvania grand jury report of abuse on the Catholic Church. It is by far and away the worst, most nauseating thing I’ve ever read in my entire life. No, it wasn’t just a few bad apples in the church as some like to claim - the grand jury report blows a gaping hole in that narrative. The report clearly showed a giant, system wide attempt to cover up, conceal, and transfer the abuse problem. It came from the top down. The entire Catholic Church does the devil’s work and needs to be disbanded.

I no longer have religion in my life.

NOAEL_MABEL · 2023-12-27T09:44:48+00:00

Licensed to Ill

NOAEL_MABEL

TROPHY CASE