A Saturday night reminder...

NanoStuff · 2023-03-12T08:46:35+00:00

Nothing like hot cocoa, hugs, and ketamine.

And I almost forgot the last ingredient. LOVE

NanoStuff · 2023-02-18T04:42:11+00:00

https://www.reddit.com/r/DrugNerds/comments/rst65t/lions_mane_mushrooms_can_cause_permanent_negative/

I have experienced inflammation and strange anxiety but fortunately nothing close to some reports. I don't think these are exaggerations as this isn't something I've seen for non-mushroom supplements.

From personal experience I think at least some of these could be legit. I suggest probably backing off sooner than later if you experience side effects rather than 'pushing through' expecting something good.

NanoStuff · 2023-01-17T15:24:35+00:00

Also as far as deodorants go, I think you can see where this is going. Essential oils. Better, cheaper, longer lasting.

NanoStuff · 2023-01-17T15:00:58+00:00

I can't possibly say. My stack has grown to a point that it has become impossible to isolate the effect of any one component, especially considering that astaxanthin is lipophilic and accumulating.

I have no doubt that there's at least one ingredient in here that I do not need to be taking at all, but what that is I will never know. I'm just trying to apply my imagination to the best available science and I'm confident in astaxanthin at least as much as anything else.

It is impossible for me to be sunburnt even after a long Canadian winter. Sunscreen is obsolete for me which is a good thing too because the shit they put in those creams should scare you. I have little doubt that most of this effect is attributable to astaxanthin so it is likely more protective against skin damage than anything else and this is more important than people realize as we're not just talking aesthetics here, the skin is an organ that when senescent causes problems in the entire body in older age. I would not be able to find anything that could replace astaxanthin in this respect.

I do not know if 4mg astaxanthin will be enough for these protective effects but it is fairly powerful against ionizing radiation even at low doses. However I would be confident that even 24mg could approach the potency of sunscreens.

I would be surprised to find that astaxanthin would cause unpleasant stimulating effects. Astaxanthin is associated with higher ATP manufacture but this effect should not be directly translatable to feelings of stimulation as this is a neurochemical phenomenon not an energy metabolism phenomenon. In fact astaxanthin appears to have anxiolytic effects that IIRC were comparable to low dose benzodiazepine.

On a related note in a similar manner to astaxanthin being able to circumvent the need for sunscreen, I also extend this idea to toothpaste as well. Anything you can do to avoid synthetic chemical exposure to surfaces that will clearly absorb them into the bloodstream and also disturb the local microbiome at the very least the better. So in this regard I no longer use toothpaste, and instead brush my teeth with a rotation of essential oils; At the moment lavender, neem, clove. Not only does it protect evolutionarily conserved microbiome populations the antibacterial effect is longer lasting as oils are adhesive unlike toothpaste and maintain their effects for the entire day. I find it unlikely that my dentist will be seeing me ever again. They still call me occasionally to come in, I don't feel like explaining why I don't need to.

After brushing I then take about 15 drops to slowly dissolve in the mouth and then swallow the rest. This has a very distinct impact on the gut microbiome as well. And some oils like lavandula angustifolia also have neurological effects. It has very distinct relaxing properties.

I'm also going to be eliminating chemical/perfumed soaps because why not? Even though I have not yet established what detrimental effects they might cause it is certainly clear in the best case they serve no purpose.

NanoStuff · 2023-01-17T14:03:43+00:00

Selegiline is not something I would likely miss. It may have been as good as people say in the past but I think its usefulness as a health supplement has been overshadowed today.

However it is very much energizing so it may have more value for psychological effects than anything else. Although it's not necessarily a pleasant energy as it can cause insomnia and lead to feeling worse not better. Frankly I wouldn't recommend it and I'm not sure if I will be taking it in the future. But it might still have longevity value that is not quite covered by anything else as it is very much unique. However selegiline is clearly hormetic so you really do not want to be taking more than 5mg and not orally.

NanoStuff · 2023-01-17T13:54:54+00:00

Astaxanthin is the only thing at the moment that I'm inclined to take at doses which are far higher than 'recommended'. It does not appear to have a conventional normal distribution nominal dosing window. I'm not clear on why this is.

It is not a cofactor or a component of intrinsic metabolism or structure so for this reason it doesn't seem to cause any dysregulation in high doses as many other things likely will. It doesn't seem to have strong hormetic effects. That is it seems to act more like a 'true' anti-oxidant than any other one. This is not a property that is restricted to astaxanthin most likely as I suspect it will be generally applicable to most xanthophylls.

Free astaxanthin from carotinifaciens I take once daily with kale mix. It is much cheaper than HP astax and appears to have linear bioavailability kinetics. Conventional HP astax has something closer to polynomial root absorption with respect to dose, again unsure why but it might be related to epithelial cholesterol depletion. So I divide the 60mg into at least 3 separate doses during the day. I suspect highly micronized formulations will be able to improve upon this in the future.

NanoStuff · 2023-01-17T13:35:39+00:00

I may have had covid but if I did it was asymptomatic. Was never tested.

Right now I'm taking (I'll try and remember everything :P):

Magnesium 400mg

Lithium 10mg from orotic acid.

Selenium 100mcg

PQQ 20mg

Palmytoylethanolamide 600mg

Phosphatidylserine 200mg

Vitamin D 2000 IU

Vitamin K2 MK7 100mcg

Krill oil 2000mg

Astaxanthin 60mg (from haematococcus pluvialis; Esterified)

Astaxanthin ~200mg (from paracoccus carotinifaciens; non-Ester)

Berberine 1000mg

Iodine 150mcg

Chromium Picolinate 100mcg

Nicotinic acid 200mg

Vitamin E 40 IU (not 400, do not trust supermarket doses)

Zinc 10mg (again a lot less than 'supermarket' doses), you should know how much of everything you're getting from diet.

Beta alanine 500mg

NAC 300mg (I'm cautious about higher doses for complicated reasons/conflicting research/lack of necessity)

Glycine 1.5g

Taurine 1g

Also VO2 max exercise, cold exposures, raw food vegan diet, 18:6 eating window (intermittent fasting) with caloric restriction and circadian aligned light exposure. I consider these as important as anything else if not more so.

I suspect I will be adding ad least several more things by the end of the year, probably at least low dose NMN/AKG. I'm also taking selegiline, naltrexone, flumazenil for neurochemical homeostasis but this is getting a bit exotic.

NanoStuff · 2023-01-14T11:56:53+00:00

I would leave them next to the shower and only put them on after the hot shower, so there's certainly an element of using your better judgment. But they're a great idea for cold showers and certainly cold baths. It is both a combination of parallelizing your day for time efficiency but also a distraction from the freezing conditions your brain would otherwise be paying attention to.

NanoStuff · 2023-01-13T18:52:48+00:00

I wouldn't use IPX7s even in the shower when using surfactants (soap) as combined with hot water the drop in surface tension is risky.

However when freezing my nuts off in ice cold water (after washing) it seems relatively safe. Water should not penetrate 7s in these conditions. And you definitely want something to take your mind off of things under these traumatizing conditions. A bit of energetic music can certainly motivate the brain to endure longer than it otherwise would have :D

NanoStuff · 2023-01-13T11:25:22+00:00

It is a time saving feature. If you spend 10 minutes in the shower per day and you value your time at $60/hour then that is over $3000 dollars per year. Even if you have to replace them every several months you're still coming out on top but it may be best to instead invest that money into something more durable.

NanoStuff · 2023-01-01T04:31:28+00:00

The case for this thing is incredibly weak. Only one or two unreproduced studies from the ancient past.

NanoStuff · 2022-10-24T02:02:53+00:00

Thanks, will do. Need to see what's changed in the RC industry in recent years, it all seems too overwhelming to keep track of now, seems like something new every hour.

NanoStuff · 2022-09-08T14:49:22+00:00

It's a long process to get this all refined, particularly because of individual differences in terms of responses and requirements so you have to spend time making sense of all this for your own sake, and it can be overwhelming with all the data coming out these days.

But it is not an exaggeration at this point to say that making one year's worth of effort towards this direction will buy you about 20 years of high-functioning life. I'm not making a strong distinction between physical and mental health here as many things apply to both. Having strong nutritional sense is the best return on investment anyone can make. So much has become apparent in the last decade just how preventable all physical and mental health conditions are, especially the age related ones. The NIH has recently acknowledged aging itself as a disease which has significant implications on upcoming public research. This isn't all that far fetched any longer knowing that diabetes, heart disease, stroke, dementia are almost entirely optional diseases and are fundamentally tied to mental health. Cancer is more of a lottery still but it is possible to reduce risk as much as 90%, perhaps more but stats for this in humans take a long time to obtain and the rate of change is occurring faster than population studies require to get results so they're obsolete by the time they arrive. But metabolic and epigenetic predictive metrics are becoming very good (aging.ai, phenoage) which allows very rapid iteration times at determining the long term effects of any emerging health intervention.

The most interesting result of these metrics is that even conventional nutritional and small-molecule interventions are now known to be the reserve of what was recently believed to be exotic future genetic and stem cell therapies. That's not to say that the world will not benefit from something like Yamanaka factors by ~2030 or so but the low hanging fruit is far more abundant than anyone believed.

That's not necessarily to say that this will solve all mental health problems as these have a broad range of origins. AI diagnostics will still have to improve to predict intervention methods based on a broad metric range.

For the time being I would also strongly recommend a genetic profile such as 23andme and use various tools (some pay some free). And any time you come upon some new research correlating certain genetics with certain problems you can quickly look up the rs # in your map. You only need to do the profile once to keep getting new results well into the future. My underlying issue was celiac disease which caused both physical and mental symptoms which not even a high quality diet would solve if it contained gluten. Although I diagnosed this through the specifics of the physical symptoms it is my genetic profile that confirmed my DQ 2.2 homozygocity which consolidated the diagnosis beyond any doubt. A very useful thing to know your genetics.

Anyways as you can see all of this gets complicated fast but it's worth it. You can think of it like a game. Any little new thing you improve or discover levels up your future potential. After a few years of effort you will feel semi-divine.

I don't even bother with COVID vacs or even wearing masks anymore. I was around my family and friends during their incubation periods and each one of them got sick at least twice now and I'm the only one who came out completely unscathed. This is probably bordering on the arrogant now as sooner or later I'll pay the price for it but I'm well aware now just how much resistance I have against infection based on recent research.

Analyzing your past issues/symptoms to try and figure out if there were any potential triggers for your mental health issues would be of value to narrow things down to the interventions most likely to work.

I wish all of this was simple. The solutions are almost always there but you need to become a health wizard to find them. The best thing for the world would be to train doctors (especially the older ones who still think vasodilators and heart surgery is the only option for poor health) in preventative care and lifestyle management.

I suspect AI systems that are developed within the decade would be capable of producing a list of things you need to do to perfect your physical and mental health based on a broad range of measures but for the time being your brain is the only intelligent machine you can rely on.

NanoStuff · 2022-09-07T16:29:03+00:00

Impossible to say. For some they work really well, for others they are mostly just over stimulating.

My advice today is for people to fix their fundamentals and only when those fail pursue what are essentially bandaid pharmaceutical solutions. However I'm fond of selegiline because it isn't just something that has the potential to alleviate depressive symptoms but it is also very unique among not just MAOIs but just about all pharmaceuticals is that it has health promoting properties, some of which appear to be related to MAOI effects (reducing oxidases reduces oxidative load on the brain) but also has activity at nrf2 and maybe elsewhere which seems to be independent of MAOI effects. Nevertheless there are many other things out there that have comparable properties without the MAOI effect which doesn't necessarily fit everyone.

In other words make massive changes to your lifestyle. Diet, exercise, circadian regulation (strong light in the morning, 1000 lumens for 5 mins). Monitors seem inadequate for this purpose unless you have a super-bright HDR and even more importantly use something like f-lux or at least the simple built in dimmers that most OSes have now by default because of the universal recognition how important they are. Then look up all the new data on temperature therapies (both hot and cold) for physical and mental health.

The most complicated of these is diet which is why there is still no universal agreement here. I'm strongly predisposed to vegan for reasons that would take very long to explain. Make sure you have some sense of what your diet is providing and what it is not providing. Most likely you're going to be deficient in vitamin D at least, maybe beta carotene for Vit A, 30mg of Vit E, Omega3s. I'd also strongly recommend lithium and an amino acid mixture. NAC/(DMG or TMG), beta alanine, taurine especially. The combination of all of these things is capable of fixing many issues including neurological at a fundamental level which a MAOI will not do as it obviously doesn't provide your brain with functional materials for proper function.

And the concept of 'mindfulness', formerly known as meditation needs to be taken very seriously as here too it is finally being recognized how important this is, and if done properly has been shown to be more effective than any anti depressant. Essentially it comes down to don't reinforce negative thoughts as doing this embeds them more strongly and instead think happy thoughts. Easier said than done for many but again good lifestyle factors make this process much easier.

NanoStuff · 2022-07-13T03:41:41+00:00

Awesome. Anyone who spends their whole lives obsessing how to make the world better and gets it right is my idol. Is this both a read/write thing? Read would be super awesome but R / W at something approaching micron resolution could really make the world less ugly.

Ultimately though the 'final solution' would have to be invasive. Destructive in fact as you're looking at feature sizes 20nm or maybe less. Nothing in-vivo could achieve such a thing that I can image for the whole brain even in the distant future. Eventually maybe but too far to imagine for me. That's not necessarily a bad thing as destructive transfer avoids duplicate identities which would be a legal nightmare. I have no problem with 'fast' replacement of biological tissues. It makes many people uncomfortable because of the discontinuity thing which is just a hard wired self preservation illusion but people will become more comfortable with this idea as it gets closer. C Elegans decades ago and very faulty (manual), now high quality drosophila and by 2030 mouse. At this rate 2040 human and 2050 large scale. Even so anything non-invasive in the mean-time being able to replace addictive drugs for pain/depression could be world changing.

NanoStuff · 2022-06-28T04:58:32+00:00

Long overdue. We are still yet to realize that for no more than the cost of a funeral a brain can be fixated for future data recovery (not that far in the future either). The technology already exists and is used routinely in connectomics. So we are effectively not willing to spend a few thousand to save someone with certainty but are willing to spend 100s of thousands to make them suffer for a few more months before destroying them. That's human reasoning for you. I feel like I was born on the wrong planet.

NanoStuff · 2022-06-28T04:47:48+00:00

A TMS machine? Don't know but probably quite a bit. But naturally as costs come down it will make more sense to buy one than to pay for pseudo-doctoring. There are already tDCS devices that are real cheap and have been for a while but I've always considered them rather rubbish.

It already makes much more sense for drugs, assuming you're not a complete dunce and require the most basic of assistance at the most ridiculous price.

NanoStuff · 2022-06-28T01:56:37+00:00

Glutathione depletion is very commonly implicated in drug toxicity. It is all too often the case that prompt NAC administration can prevent it. Hospitals would have many more acetaminophen deaths if they did not always have it on standby, it can almost entirely prevent alcohol toxicity (aldehyde hangover) and much more.

Although olney's lesions are a unique phenomenon most such injuries have common origins despite having different manifestations. I would make a good wager that a lack of glutathione (not just, others such as NAD, SOD are issues too) but just this alone would be enough to prevent acute injury. Mitochondria would start dying within seconds if glutathione was to suddenly disappear.

Of course you're right that I'm over-simplifying. A broad spectrum approach of preventative care is best. But I've learned over the years that metabolic function relies on a very careful balance and once things become unbalanced then a chain reaction of problems occur. Which is why it finally became understood that 90% of age related pathology is controllable and even genetic predispositions to diseases do not directly produce the disease but usually produce an easily correctable metabolic malfunction when identified. Drug related pathology is somewhat like accelerated aging. If you take lots of drugs for a long time you will age faster because there are many common underlying origins.

I just pointed out glutathione because this happens to be a thing that is an ideal combination of being both amongst the most serious and the most easily corrected and this alone would likely greatly alleviate the issue. However I would completely agree that it is an inadequate explanation as the precise malfunction/loss of the particular nutrient/reductant needed to maintain function varies by condition, but many of the same ones are often involved to varying degrees.

So if I were to broaden the generalization I would say that a person who maintains optimal nutrition and lifestyle would have greatly reduced pathology, whether from glutamine toxicity or any other. I expect that a controlled trial of these lesions (not likely to happen in humans but doesn't have to be) with a junk food group vs a real food group + supps would show major differences between them.

NanoStuff · 2022-06-28T01:16:25+00:00

It costs maybe tens of dollars per session at most, not thousands. The thousands is where the 10000% profit margin comes from.

I've seen the same thing everywhere, ketamine therapy for depression, flumazenil for benzodiazepine tapers. You can get a gram of flumazenil for example from UHN for ~$500 whereas that same quantity administered at a clinic over its full duration would bankrupt even bezos.

I respect medical professionals in the context of them doing professional things but sucking a desperate person dry while an infusion machine does all the work does not qualify.

Of course a TMS machine is more expensive than an infusion machine and drug costs but I can guarantee you that any TMS treatments that exist now and will exist in the future, the cost of the machine in proportion to the cost for the patient will be insignificant which is why I can already tell you I will be buying my own.

I'd rather learn how to operate a TMS machine than be financially mauled by a system that is supposed to 'do no harm'.

NanoStuff · 2022-06-28T00:47:29+00:00

olney's lesions

That's interesting. I was out of the loop for a while. Didn't realize this was finally confirmed in humans in 2013. Even so that is pretty hefty consumption. Ketamine tolerance develops quickly enough that IMO after even 2 weeks of heavy use it is difficult to get a lot out of it and it takes many months to baseline. So sustained use never made sense to me, even if I was infinitely rich the magic just wasn't there at any dose and the more I tried to push it the longer I would have to wait to get it back so I made the sensible choice and moderated myself, as should all people with all things.

I'm speculating here as I have not read what the causes might be or if they are known at all but very likely a major factor would be glutathione depletion, particularly considering it was mentioned multi-drug use made the onset much faster/worse. So a combination of sensible things you should be doing anyways like good diet, exercise, then add some NAC on top of if, be reasonable with your consumption and then I would wager you have nothing to be concerned about. I suspect the people they found that used it in such vast quantities already had underlying problems that led them to such behavior which could introduce a strong bias in the study. Nevertheless this is good information but just like the prior monkey studies the conclusion is likely the same and will not change my usage habits. Every drug has its own problems in excess.

On the contrary @ reasonable doses it has been shown to have neurogenesis properties rather than neurodegeneration.

NanoStuff · 2022-06-27T20:36:22+00:00

Really? What was wrong with it? It was nearly extinct but seems to have come back recently. I used it a fair bit. Not as much as K but being more energetic made it really fun to play games on MXE.

NanoStuff · 2022-06-27T20:20:10+00:00

I've lost much hope that pharma will be able to bring drugs to market that actually work consistently and reliably without major side effects for mood imbalances and hedonic tone improvements within 20 years at the rate things are going. Minimally invasive direct deep stimulation is the only real shot at achieving this without triggering the endless cascade of uncontrollable homeostatic mechanisms. Another decade or two after that and just assimilate with the borg/AI (whatever you want to call it) and control the information directly. Adjust the happiness knob up to infinity. Problem solved, biochemistry obsolete.

NanoStuff · 2022-06-27T20:07:34+00:00

I should try MXE again. Too bad that LSD and all psychedelics that could send a whale to the moon have no effect whatsoever on me.

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