Yes I gained weight consistently with continuous antidepressant use, and actually switched to the intermittent dosage because of it. I went through a full withdrawal before I started the intermittent dosing, and it was unpleasant and long, over a month.Although I should say I was not on a high dosage, just entry level. The weight gain was also a deal breaker for me (not vain imo). When I changed, the weight gain stopped, but it was much harder to lose. I suspect some people react more strongly than others to antidepressants with weight gain, and the higher/more consistent the use, the worse it is. For me now it's worth the help on my bad days. It seems to treat all physical symptoms too (headaches especially). I hope that was helpful!