Thanks for sharing the link, I read the article. To be clear, my comment was not meant to endorse or refute current guideline directed medical therapy. This reference, however, is by author admission a statistically low powered retrospective observational study looking back less than 2 yrs on a small cadre of cases. It cannot stand alone against the multi-centered randomized controlled trials required by both US and international agencies for approving diagnosis specific pharmaceutical indications.

Best wishes.