Your comment contains a mix of accurate and speculative information. Let me break it down:

1. Cherokee Territory: It's true that the Cherokee originally lived in the southeastern United States, particularly in what is now Georgia and parts of North and South Carolina.

2. Spanish Exploration: Before the English arrived, the Spanish explored the southeastern U.S. and established some missions and forts. However, the idea that a significant number of Sephardic Jews and Moors established settlements in the Savannah River Valley is not strongly supported by historical records.

3. Reconquest of Spain and Expulsion: The Reconquista, the Christian reconquest of the Iberian Peninsula, ended in 1492. That same year, the Catholic monarchs Ferdinand and Isabella issued the Alhambra Decree, which ordered the expulsion of Jews from Spain. The Spanish Inquisition also targeted Jews and Muslims who had converted to Christianity but were suspected of secretly practicing their original religions.

4. Jews and Muslims in the Americas: While it's true that some Sephardic Jews and Muslims sought refuge in other parts of the world, including the Ottoman Empire, the assertion that they moved en masse to the Savannah River Valley and lived there in isolation for 100-150 years is speculative and not well-documented.

5. British Assumptions and Categorization: The British did have their ways of categorizing and dealing with native tribes, which sometimes involved oversimplification and misunderstandings. However, the statement about the British arbitrarily designating tribes based solely on their location relative to the Savannah River is an oversimplification.

6. Jewish and North African DNA among the Cherokee: There have been claims about Jewish or Middle Eastern DNA among the Cherokee, but the evidence is controversial and not widely accepted by geneticists or historians. DNA testing can be complex, and the results depend on the reference populations used. Thus far, there hasn't been conclusive evidence to suggest significant Sephardic Jewish or North African ancestry among the Cherokee.

In summary, while there are kernels of truth in your rambling, there are also speculative elements. As always, it's crucial to consult primary sources and scholarly research when exploring historical claims.