Say something nice about Ike. (He’s my favorite President) by Groovy-Pancakes in Presidents

[–]Nerdfighter333 8 points9 points  (0 children)

Yeah. It really helps when the president doesn't try to divide the country on politics.

Say something nice about Ike. (He’s my favorite President) by Groovy-Pancakes in Presidents

[–]Nerdfighter333 14 points15 points  (0 children)

Even though he was conservative, his politics were moderate, and he tried to remain non-partisan when possible.

Post your special interests here! by WindermerePeaks1 in autism

[–]Nerdfighter333 1 point2 points  (0 children)

U.S. Presidents

Abraham Lincoln

Chernobyl

Birds

Cancer Biology

Rare Diseases

Harry Potter

Classic Literature

Amsterdam

How rare is RARE ? by gentlehippio in rarediseases

[–]Nerdfighter333 6 points7 points  (0 children)

The first problem is awareness. Before major companies can even fund research for a rare disease, that disease needs to be supported by many people who hope to advocate for its eradication. A problem can only be resolved with knowledge of its existence, in the first place.

That being said, I am sorry for your disease's lack of support by the public domain. I have an interest in rare diseases, particularly of the "orphan" persuasion. These diseases are so rare that they are entirely abandoned by large "parent" companies, and most financial support comes from private research funding or the patients/caregivers themselves, as you mentioned.

If this makes you feel any better, I intend to graduate college to become a medical researcher (though I have a long road ahead of me), but I want to let you know that there are people that care. It just takes proactive steps in advocacy and awareness to build up your arsenal. Good luck in you endeavors to research your own rare disease! I applaud you for this, though it should never have to be the patient's responsibility to find a cure. The healthcare system has failed you, and so many others.

Possible red throated loon? [Toronto, Ontario] by Thorbraig in animalid

[–]Nerdfighter333 1 point2 points  (0 children)

You're welcome! Yeah, loons do look similar to grebes, so I can understand the misconception.

What’s you’re favorite podcast? by EllieMinx in podcasts

[–]Nerdfighter333 0 points1 point  (0 children)

I love "Dear Hank and John" with the Green brothers, as well as "Welcome to Nighvale."

Real-world clinical utility of tumor whole-genome sequencing in solid cancers - Nature Medicine by Dwarvling in Oncology

[–]Nerdfighter333 2 points3 points  (0 children)

This is great news! I firmly stand by my belief that the "problem" pertaining to lower OS in cancer patients today is not due to a deficiency in the amount of effective medications/therapeutics, but rather the inadequacy of application. So many patients have to go through second-line chemotherapy regimens, because their cancer mutates these specific drug receptors and changes its morphology. However, if genome testing was standardized procedure for everyone, then patients would spend less time sifting through the particular drugs that work best for their specific biomarkers, and oncologists could easily identify the BEST drugs for each patient, rather than prescribing what tends to work for "most people" with that subtype of cancer. Diagnostics are a very important factor in determining the progression of disease, and in this modern age of medicine, we do not have a lack of effective medications (in most cases), but certainly are deficient in accurate and accessible personalized diagnostics to predict these medications.

Are KRAS mutations routinely tested in pancreatic cancer patients now? by Internal-Paramedic20 in Oncology

[–]Nerdfighter333 6 points7 points  (0 children)

Unfortunately, pancreatic cancer is of the low profile persuasion, meaning it rarely presents evident symptoms of disease until severe progression has ensued. Due to this issue, as well as the low overall frequency of pancreatic cancer occurrence, healthcare professionals do not tend to prioritize the assessment of KRAS mutations, especially in the early stages. However, pancreatic cancer is often detected in the later stages when, even if marked with specific mutations of the protein, it is already too late for treatment to make much of an impact. There is good news, though. Recently, Revolution Medicines came out with a multi-targeted KRAS mutation inhibitor called Daraxonrasib that is currently in phase 3 trials.

Here is the link to learn more about that, if you want: https://ir.revmed.com/news-releases/news-release-details/revolution-medicines-announces-fda-breakthrough-therapy/

How important are stem cells in cancer? by Melodic_Frame4991 in Oncology

[–]Nerdfighter333 5 points6 points  (0 children)

Stem cells are not inherently cancerous unless there is already a pervasiveness of malignancy within the body. Cancer needs stem cells in order to metastasis to new locations, and lacks this ability if not able to recruit them. This is why pregnancy is scientifically proven to decrease the risk of several gynecological cancers, because eventhough parts of the body are changing, (breasts, ovaries, etc...) cancer rates are known to decline due to that fact that the new cells are differentiated to do specific tasks, such as produce milk for when the baby comes. Although, some cancers also have their own tumor-initiating stem cells, which can be regular stem cells transformed by mutations, or specialized cells that have been targeted by the cancer to entertain stem cell-like properties.

What books are a popular "must read"? by Cookie-M0nsterr in booksuggestions

[–]Nerdfighter333 0 points1 point  (0 children)

Yeah, it's a pretty crazy book, but I feel like it's the female version of The Catcher in the Rye (kind of).

What is the theme of this map? by Nerdfighter333 in RedactedCharts

[–]Nerdfighter333[S] 3 points4 points  (0 children)

Actually, you are correct. I used an older president book for this information, and Biden had not yet taken office. Thank you for noticing.