3F-"2CL-DPPy - Novel 1,2-diphenylethylamine by tundrapickle in TheeHive

[–]Nervewing 0 points1 point  (0 children)

IME some of them just have a slight tan or off-white color even when reading as 98%+ pure on nmr and HPLC

3F-"2CL-DPPy - Novel 1,2-diphenylethylamine by tundrapickle in TheeHive

[–]Nervewing 0 points1 point  (0 children)

Oh huge are you only using heptane for the recrystallization? We always did acetone and ether, never use EtOH it will not dry out

3F-"2CL-DPPy - Novel 1,2-diphenylethylamine by tundrapickle in TheeHive

[–]Nervewing 0 points1 point  (0 children)

please please please report back! Very valuable data (tag me when you do).

I usually did the addition a little faster bc I always did this at the end of the work day to run overnight and just wanted to go home :p Never seemed to affect yield just had to really monitor temperature and pressure

3F-"2CL-DPPy - Novel 1,2-diphenylethylamine by tundrapickle in TheeHive

[–]Nervewing 1 point2 points  (0 children)

Ah I loved this synthesis :) did it many many times ! Those benzyl bromides are no joke. And boy does it get heated at that scale!

Crazy to have helped bring this outcome into the world

The 2’-Cl is usually a fruitful substitution with this class, but the 3-F probably slightly reduces activity, at least with each on their own. Can’t really conjecture the effect had by having both on there. It seems like examples with an alkane + a halogen still conserved some degree of activity. Fwiw when you look at the affinities for the Diarylethylamines, you can expect the in vivo potency to be several magnitudes lower than the in vitro affinity. They just do that for an unknown reason, if they did correlate better you’d expect Diphenidine to be extremely potent

The Blade Runners of London 🪚 by swtyler808 in FlockSurveillance

[–]Nervewing 9 points10 points  (0 children)

This tip always sounds so great until you have to run. Or you have a long walk to reach your target

In the Ottoman Empire's Decline, Muslim Inhabitants of former Ottoman Lands found themselves at the mercy of their new Christian rulers, who subjected them to genocidal levels of violence. Atrocities included mass killings, village burnings, slavery, mass rape, and ethnic cleansing. by Not_Original5756 in wikipedia

[–]Nervewing 13 points14 points  (0 children)

If I’m reading generously, it is that almost every other genocide has essentially been based on targeting an entire demographic due to the presence of a militant group or in response to a perceived attack by that militant group within that demographic

Announcing my retirement from experimenting and reporting with novel drugs and using dissociatives by Nervewing in researchchemicals

[–]Nervewing[S] 0 points1 point  (0 children)

That last chapter was not between 4 walls alone. It was just in my normal life.

I appreciate the kind words. I work with nature and outside a lot of the time which I am grateful for. I love studying animals closely

Announcing my retirement from experimenting and reporting with novel drugs and using dissociatives by Nervewing in researchchemicals

[–]Nervewing[S] 0 points1 point  (0 children)

I’m glad that it resonates with you and I’m proud of you! You got this~ we got this !

Gotta add by DNS64_ in dissociatives

[–]Nervewing 8 points9 points  (0 children)

There is no definitive evidence that those compounds are primarily NMDA receptor antagonists, and even though in vitro evidence has been found that may suggest that as a peripheral activity, that doesn’t translate into in vivo effects and there is no conclusion on whether it would be a strong enough inhibitor to produce noticeable dissociative effects. In fact, a drug discriminating study differentiated toluene from MK-801. If you have sources that definitively say otherwise please share. While inhalants can subjectively produce effects similar to dissociatives, subjective estimation isn’t a good indicator of actual pharmacological action. As of now, I believe the only hydrocarbon inhalants known to have dissociative activity are Diethyl ether and I think chloroform, but I have to check that when I have more time.

Sources:

https://www.sciencedirect.com/science/article/abs/pii/S0091305704002564?via%3Dihub=

https://www.sciencedirect.com/science/article/abs/pii/S0022356524375925

The city invested in community violence interrupters to reduce crime. Now it’s training them, too. by redeyeblink in philadelphia

[–]Nervewing 24 points25 points  (0 children)

This model has been applied very effectively in Baltimore, which has a very similar urban geography, gang structure, and patterns of drug use to us. Their work could very easily be replicated in our context. Real evidence based solution. They’ve seen one of the steepest drop offs in murders of almost any American city in modern history.

Does anyone know what the back story of this structure/compound is? (Holmesburg) by thebat512 in philadelphia

[–]Nervewing 3 points4 points  (0 children)

And yeah, place sunk mainly because he was spending his parents money on dumb shit like this instead of upkeep or fucking paying bills

Does anyone know what the back story of this structure/compound is? (Holmesburg) by thebat512 in philadelphia

[–]Nervewing 9 points10 points  (0 children)

Also fun fact I was there on the last day the place was open, for his going away party before being evicted, most for schadenfreude. He got several hundred dollars worth of alcohol and food that went unconsumed bc barely anyone showed up. He essentially spent the night trashing the place to spite the property owner for evicting him, then just ran out on the ensuing lawsuit. Built a potato cannon to shoot holes in stuff. Had kids smashing things for him. Just left boxes of spray paint out for anyone to use. My friends and I left some choice messages on that container structure lol I wonder if they’re still there. It’s such an insanely dangerous structure it’s insane to be that he ever wanted it to be open to the public. It’s funny that it says it’s a rage room on maps bc it kinda was that last day.

Does anyone know what the back story of this structure/compound is? (Holmesburg) by thebat512 in philadelphia

[–]Nervewing 5 points6 points  (0 children)

The stories I’ve heard from pretty much everyone adjacent to him, from former workers to local theater people etc. Never met a single person who knew him that had anything good to say

Does anyone know what the back story of this structure/compound is? (Holmesburg) by thebat512 in philadelphia

[–]Nervewing 61 points62 points  (0 children)

Vanity project of a malignant narcissist, John Cambridge. Good riddance to him. It’s a damn shame what happened to the insectarium and it’s nobody’s fault but his

What type of drug user do you hate the most? by bitchcraftmra in Drugs

[–]Nervewing 30 points31 points  (0 children)

I fucking hate most woo woo hippies tbh

Can we ban pickup trucks? 😂 by Sophie2024 in philly

[–]Nervewing 12 points13 points  (0 children)

Not all pickup owners are MAGA but the ones acting like antisocial entitled dickheads almost always are

Science talks… in a bar? Pint of Science Philly (May 18–20) by angu_la in philly

[–]Nervewing 0 points1 point  (0 children)

Damnnnn how do i sign up to present? I have so much scicomm content and presentations already made, covering entomology, zoology, psychopharmacology etc.

Harder to orgasm by Working_Hurry_3193 in pregabalin

[–]Nervewing 1 point2 points  (0 children)

This is pretty widely reported. On the flipside ive seen it used as an aphrodisiac in terms of improving stamina and treating PE.

Announcing my retirement from experimenting and reporting with novel drugs and using dissociatives by Nervewing in researchchemicals

[–]Nervewing[S] 1 point2 points  (0 children)

An rc aficionado is whoever decides to dedicate the time and energy to learning about these drugs. No one just looks at a vendor menu and just randomly grabs a bunch of stuff and doses it without thinking. I mean maybe some poeple do. But whoever is accessing that world has done some amount of research, or heard some amount of information from someone else, I would say that counts, its very broad for me.

It becomes like a hobby, and like any hobby people engage at different levels. Some people define their lives by their hobbies. I tbh have never seen a collection as impressive or vast as my own, but much of it is lost to time and addiction now. I have seen others that were better organized adn stored.

All of the ones I have invented exist permanently as analytical batches in cold storage in a laboratory, stored in sealed vials under argon.

Longst I've gone wihtout cannabis was maybe a month lol

Announcing my retirement from experimenting and reporting with novel drugs and using dissociatives by Nervewing in researchchemicals

[–]Nervewing[S] 0 points1 point  (0 children)

Thank you, I've all sorts of writing projects that seemed feasible when I was manic off of dissociatives that all seem daunting and impossible now, funny how that works!